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Pulmonary vascular changes in asthma and COPD.

Harkness, Louise M; Kanabar, Varsha; Sharma, Hari S; Westergren-Thorsson, Gunilla LU and Larsson Callerfelt, Anna-Karin LU (2014) In Pulmonary Pharmacology & Therapeutics 29(2). p.144-155
Abstract
In chronic lung disorders such as in asthma and chronic obstructive pulmonary disease (COPD) there is increased bronchial angiogenesis and remodelling of pulmonary vessels culminating to altered bronchial and pulmonary circulation. The involvement of residential cells such as endothelial cells, smooth muscle cells and pulmonary fibroblasts, all appear to have a crucial role in the progression of vascular inflammation and remodelling. The regulatory abnormalities, growth factors and mediators implicated in the pulmonary vascular changes of asthma and COPD subjects and potential therapeutic targets have been described in this review.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pulmonary Pharmacology & Therapeutics
volume
29
issue
2
pages
144 - 155
publisher
Elsevier
external identifiers
  • pmid:25316209
  • wos:000345949900007
  • scopus:84922580405
ISSN
1522-9629
DOI
10.1016/j.pupt.2014.09.003
language
English
LU publication?
yes
id
91a55fdf-e19b-421d-9988-466f1254ed44 (old id 4736919)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25316209?dopt=Abstract
date added to LUP
2014-11-09 21:13:45
date last changed
2017-11-05 03:01:27
@article{91a55fdf-e19b-421d-9988-466f1254ed44,
  abstract     = {In chronic lung disorders such as in asthma and chronic obstructive pulmonary disease (COPD) there is increased bronchial angiogenesis and remodelling of pulmonary vessels culminating to altered bronchial and pulmonary circulation. The involvement of residential cells such as endothelial cells, smooth muscle cells and pulmonary fibroblasts, all appear to have a crucial role in the progression of vascular inflammation and remodelling. The regulatory abnormalities, growth factors and mediators implicated in the pulmonary vascular changes of asthma and COPD subjects and potential therapeutic targets have been described in this review.},
  author       = {Harkness, Louise M and Kanabar, Varsha and Sharma, Hari S and Westergren-Thorsson, Gunilla and Larsson Callerfelt, Anna-Karin},
  issn         = {1522-9629},
  language     = {eng},
  number       = {2},
  pages        = {144--155},
  publisher    = {Elsevier},
  series       = {Pulmonary Pharmacology & Therapeutics},
  title        = {Pulmonary vascular changes in asthma and COPD.},
  url          = {http://dx.doi.org/10.1016/j.pupt.2014.09.003},
  volume       = {29},
  year         = {2014},
}