Pulmonary vascular changes in asthma and COPD.
(2014) In Pulmonary Pharmacology & Therapeutics 29(2). p.144-155- Abstract
- In chronic lung disorders such as in asthma and chronic obstructive pulmonary disease (COPD) there is increased bronchial angiogenesis and remodelling of pulmonary vessels culminating to altered bronchial and pulmonary circulation. The involvement of residential cells such as endothelial cells, smooth muscle cells and pulmonary fibroblasts, all appear to have a crucial role in the progression of vascular inflammation and remodelling. The regulatory abnormalities, growth factors and mediators implicated in the pulmonary vascular changes of asthma and COPD subjects and potential therapeutic targets have been described in this review.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4736919
- author
- Harkness, Louise M ; Kanabar, Varsha ; Sharma, Hari S ; Westergren-Thorsson, Gunilla LU and Larsson Callerfelt, Anna-Karin LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pulmonary Pharmacology & Therapeutics
- volume
- 29
- issue
- 2
- pages
- 144 - 155
- publisher
- Elsevier
- external identifiers
-
- pmid:25316209
- wos:000345949900007
- scopus:84922580405
- ISSN
- 1522-9629
- DOI
- 10.1016/j.pupt.2014.09.003
- language
- English
- LU publication?
- yes
- id
- 91a55fdf-e19b-421d-9988-466f1254ed44 (old id 4736919)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25316209?dopt=Abstract
- date added to LUP
- 2016-04-01 09:52:07
- date last changed
- 2024-02-20 22:33:54
@article{91a55fdf-e19b-421d-9988-466f1254ed44, abstract = {{In chronic lung disorders such as in asthma and chronic obstructive pulmonary disease (COPD) there is increased bronchial angiogenesis and remodelling of pulmonary vessels culminating to altered bronchial and pulmonary circulation. The involvement of residential cells such as endothelial cells, smooth muscle cells and pulmonary fibroblasts, all appear to have a crucial role in the progression of vascular inflammation and remodelling. The regulatory abnormalities, growth factors and mediators implicated in the pulmonary vascular changes of asthma and COPD subjects and potential therapeutic targets have been described in this review.}}, author = {{Harkness, Louise M and Kanabar, Varsha and Sharma, Hari S and Westergren-Thorsson, Gunilla and Larsson Callerfelt, Anna-Karin}}, issn = {{1522-9629}}, language = {{eng}}, number = {{2}}, pages = {{144--155}}, publisher = {{Elsevier}}, series = {{Pulmonary Pharmacology & Therapeutics}}, title = {{Pulmonary vascular changes in asthma and COPD.}}, url = {{https://lup.lub.lu.se/search/files/1335532/7853003.pdf}}, doi = {{10.1016/j.pupt.2014.09.003}}, volume = {{29}}, year = {{2014}}, }