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Lung Function and CT Densitometry in Subjects with alpha-1-Antitrypsin Deficiency and Healthy Controls at 35 Years of Age.

Piitulainen, Eeva LU ; Cano Montero, Laura LU ; Nystedt-Düzakin, Meltem; Stoel, Berend C; Sveger, Tomas LU ; Wollmer, Per LU ; Tanash, Hanan LU and Diaz, Sandra LU (2015) In COPD: Journal of Chronic Obstructive Pulmonary Disease 12(2). p.162-167
Abstract
Abstract Alpha-1-antitrypsin (AAT) deficiency is a genetic risk factor for pulmonary emphysema. In 1972-74 all 200,000 Swedish new-born infants were screened for AAT deficiency. The aim of the present study was to investigate whether the PiZZ and PiSZ individuals identified by this screening have signs of emphysema and the role of smoking in this, compared with a random sample of control subjects at 35 years of age. The study participants underwent complete pulmonary function tests (PFT) and CT densitometry. The fifteenth percentile density (PD15) and the relative area below -910 HU (RA-910) were analyzed. Fifty-four PiZZ, 21 PiSZ and 66 PiMM control subjects participated in the study. No significant differences were found in lung function... (More)
Abstract Alpha-1-antitrypsin (AAT) deficiency is a genetic risk factor for pulmonary emphysema. In 1972-74 all 200,000 Swedish new-born infants were screened for AAT deficiency. The aim of the present study was to investigate whether the PiZZ and PiSZ individuals identified by this screening have signs of emphysema and the role of smoking in this, compared with a random sample of control subjects at 35 years of age. The study participants underwent complete pulmonary function tests (PFT) and CT densitometry. The fifteenth percentile density (PD15) and the relative area below -910 HU (RA-910) were analyzed. Fifty-four PiZZ, 21 PiSZ and 66 PiMM control subjects participated in the study. No significant differences were found in lung function between the never-smoking AAT-deficient and control subjects. The 16 PiZZ ever-smokers had significantly lower carbon monoxide transfer coefficient (KCO) than the 20 PiSZ never-smokers (p = 0.014) and the 44 PiMM never-smokers (p = 0.005). After correction for the CT derived lung volume, the PiZZ ever-smokers had significantly lower PD15 (p = 0.046) than the ever-smoking controls. We conclude that 35-year-old PiZZ and PiSZ never-smokers have normal lung function when compared with never-smoking control subjects. The differences in KCO and CT densitometric parameters between the PiZZ ever-smokers and the control subjects may indicate early signs of emphysema. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
COPD: Journal of Chronic Obstructive Pulmonary Disease
volume
12
issue
2
pages
162 - 167
publisher
Taylor & Francis
external identifiers
  • pmid:25280185
  • wos:000353925900007
  • scopus:84928954935
ISSN
1541-2563
DOI
10.3109/15412555.2014.922068
language
English
LU publication?
yes
id
bab6ae17-14cc-4110-b74f-84706ea06805 (old id 4738275)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25280185?dopt=Abstract
date added to LUP
2014-11-05 19:35:47
date last changed
2017-11-12 03:15:47
@article{bab6ae17-14cc-4110-b74f-84706ea06805,
  abstract     = {Abstract Alpha-1-antitrypsin (AAT) deficiency is a genetic risk factor for pulmonary emphysema. In 1972-74 all 200,000 Swedish new-born infants were screened for AAT deficiency. The aim of the present study was to investigate whether the PiZZ and PiSZ individuals identified by this screening have signs of emphysema and the role of smoking in this, compared with a random sample of control subjects at 35 years of age. The study participants underwent complete pulmonary function tests (PFT) and CT densitometry. The fifteenth percentile density (PD15) and the relative area below -910 HU (RA-910) were analyzed. Fifty-four PiZZ, 21 PiSZ and 66 PiMM control subjects participated in the study. No significant differences were found in lung function between the never-smoking AAT-deficient and control subjects. The 16 PiZZ ever-smokers had significantly lower carbon monoxide transfer coefficient (KCO) than the 20 PiSZ never-smokers (p = 0.014) and the 44 PiMM never-smokers (p = 0.005). After correction for the CT derived lung volume, the PiZZ ever-smokers had significantly lower PD15 (p = 0.046) than the ever-smoking controls. We conclude that 35-year-old PiZZ and PiSZ never-smokers have normal lung function when compared with never-smoking control subjects. The differences in KCO and CT densitometric parameters between the PiZZ ever-smokers and the control subjects may indicate early signs of emphysema.},
  author       = {Piitulainen, Eeva and Cano Montero, Laura and Nystedt-Düzakin, Meltem and Stoel, Berend C and Sveger, Tomas and Wollmer, Per and Tanash, Hanan and Diaz, Sandra},
  issn         = {1541-2563},
  language     = {eng},
  number       = {2},
  pages        = {162--167},
  publisher    = {Taylor & Francis},
  series       = {COPD: Journal of Chronic Obstructive Pulmonary Disease},
  title        = {Lung Function and CT Densitometry in Subjects with alpha-1-Antitrypsin Deficiency and Healthy Controls at 35 Years of Age.},
  url          = {http://dx.doi.org/10.3109/15412555.2014.922068},
  volume       = {12},
  year         = {2015},
}