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Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region.

Skibola, Christine F; Berndt, Sonja I; Vijai, Joseph; Conde, Lucia; Wang, Zhaoming; Yeager, Meredith; de Bakker, Paul I W; Birmann, Brenda M; Vajdic, Claire M and Foo, Jia-Nee, et al. (2014) In American Journal of Human Genetics 95(4). p.462-471
Abstract
Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 × 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10(-8)) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRβ1 multiallelic amino acids at positions 11, 13, 28, and 30 that were... (More)
Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 × 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10(-8)) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRβ1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (pomnibus = 4.20 × 10(-67) to 2.67 × 10(-70)). Additional independent signals included rs17203612 in HLA class II (odds ratio [ORper-allele] = 1.44; p = 4.59 × 10(-16)) and rs3130437 in HLA class I (ORper-allele = 1.23; p = 8.23 × 10(-9)). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk. (Less)
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American Journal of Human Genetics
volume
95
issue
4
pages
462 - 471
publisher
Cell Press
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  • pmid:25279986
  • wos:000342654300011
  • scopus:84921517901
ISSN
0002-9297
DOI
10.1016/j.ajhg.2014.09.004
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English
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53e478f7-2858-4371-9919-59c067c00ed9 (old id 4738286)
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http://www.ncbi.nlm.nih.gov/pubmed/25279986?dopt=Abstract
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2014-11-05 19:50:08
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2017-10-29 03:21:37
@article{53e478f7-2858-4371-9919-59c067c00ed9,
  abstract     = {Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 × 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10(-8)) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRβ1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (pomnibus = 4.20 × 10(-67) to 2.67 × 10(-70)). Additional independent signals included rs17203612 in HLA class II (odds ratio [ORper-allele] = 1.44; p = 4.59 × 10(-16)) and rs3130437 in HLA class I (ORper-allele = 1.23; p = 8.23 × 10(-9)). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk.},
  author       = {Skibola, Christine F and Berndt, Sonja I and Vijai, Joseph and Conde, Lucia and Wang, Zhaoming and Yeager, Meredith and de Bakker, Paul I W and Birmann, Brenda M and Vajdic, Claire M and Foo, Jia-Nee and Bracci, Paige M and Vermeulen, Roel C H and Slager, Susan L and de Sanjose, Silvia and Wang, Sophia S and Linet, Martha S and Salles, Gilles and Lan, Qing and Severi, Gianluca and Hjalgrim, Henrik and Lightfoot, Tracy and Melbye, Mads and Gu, Jian and Ghesquières, Hervé and Link, Brian K and Morton, Lindsay M and Holly, Elizabeth A and Smith, Alex and Tinker, Lesley F and Teras, Lauren R and Kricker, Anne and Becker, Nikolaus and Purdue, Mark P and Spinelli, John J and Zhang, Yawei and Giles, Graham G and Vineis, Paolo and Monnereau, Alain and Bertrand, Kimberly A and Albanes, Demetrius and Zeleniuch-Jacquotte, Anne and Gabbas, Attilio and Chung, Charles C and Burdett, Laurie and Hutchinson, Amy and Lawrence, Charles and Montalvan, Rebecca and Liang, Liming and Huang, Jinyan and Ma, Baoshan and Liu, Jianjun and Adami, Hans-Olov and Glimelius, Bengt and Ye, Yuanqing and Nowakowski, Grzegorz S and Dogan, Ahmet and Thompson, Carrie A and Habermann, Thomas M and Novak, Anne J and Liebow, Mark and Witzig, Thomas E and Weiner, George J and Schenk, Maryjean and Hartge, Patricia and De Roos, Anneclaire J and Cozen, Wendy and Zhi, Degui and Akers, Nicholas K and Riby, Jacques and Smith, Martyn T and Lacher, Mortimer and Villano, Danylo J and Maria, Ann and Roman, Eve and Kane, Eleanor and Jackson, Rebecca D and North, Kari E and Diver, W Ryan and Turner, Jenny and Armstrong, Bruce K and Benavente, Yolanda and Boffetta, Paolo and Brennan, Paul and Foretova, Lenka and Maynadie, Marc and Staines, Anthony and McKay, James and Brooks-Wilson, Angela R and Zheng, Tongzhang and Holford, Theodore R and Chamosa, Saioa and Kaaks, Rudolph and Kelly, Rachel S and Ohlsson, Bodil and Travis, Ruth C and Weiderpass, Elisabete and Clavel, Jacqueline and Giovannucci, Edward and Kraft, Peter and Virtamo, Jarmo and Mazza, Patrizio and Cocco, Pierluigi and Ennas, Maria Grazia and Chiu, Brian C H and Fraumeni, Joseph F and Nieters, Alexandra and Offit, Kenneth and Wu, Xifeng and Cerhan, James R and Smedby, Karin E and Chanock, Stephen J and Rothman, Nathaniel},
  issn         = {0002-9297},
  language     = {eng},
  number       = {4},
  pages        = {462--471},
  publisher    = {Cell Press},
  series       = {American Journal of Human Genetics},
  title        = {Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region.},
  url          = {http://dx.doi.org/10.1016/j.ajhg.2014.09.004},
  volume       = {95},
  year         = {2014},
}