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Mapping of QTL for Body Conformation and Behavior in Cattle

Hiendleder, Stefan ; Thomsen, H. LU orcid ; Reinsch, N. ; Bennewitz, J. ; Leyhe-Horn, B. ; Looft, C. ; Xu, N. ; Medjugorac, I. ; Russ, I. and Kühn, C. , et al. (2003) In Journal of Heredity 94(6). p.496-506
Abstract

Genome scans for quantitative trait loci (QTL) in farm animals have concentrated on primary production and health traits, and information on QTL for other important traits is rare. We performed a whole genome scan in a granddaughter design to detect QTL affecting body conformation and behavior in dairy cattle. The analysis included 16 paternal half-sib families of the Holstein breed with 872 sons and 264 genetic markers. The markers were distributed across all 29 autosomes and the pseudoautosomal region of the sex chromosomes with average intervals of 13.9 cM and covering an estimated 3155.5 cM. All families were analyzed jointly for 22 traits using multimarker regression and significance thresholds determined empirically by... (More)

Genome scans for quantitative trait loci (QTL) in farm animals have concentrated on primary production and health traits, and information on QTL for other important traits is rare. We performed a whole genome scan in a granddaughter design to detect QTL affecting body conformation and behavior in dairy cattle. The analysis included 16 paternal half-sib families of the Holstein breed with 872 sons and 264 genetic markers. The markers were distributed across all 29 autosomes and the pseudoautosomal region of the sex chromosomes with average intervals of 13.9 cM and covering an estimated 3155.5 cM. All families were analyzed jointly for 22 traits using multimarker regression and significance thresholds determined empirically by permutation. QTL that exceeded the experiment-wise significance threshold (5% level) were detected on chromosome 6 for foot angle, teat placement, and under depth, and on chromosome 29 for temperament. QTL approaching experiment-wise significance (10% level) were located on chromosome 6 for general of feet and legs and general quality of under, on chromosome 13 for teat length, on chromosome 23 for general quality of feet and legs, and on chromosome 29 for milking speed. An additional 51 QTL significant at the 5% chromosome-wise level were distributed over 21 chromosomes. This study provides the first evidence for QTL involved in behavior of dairy cattle and identifies QTL for udder conformation on chromosome 6 that could form the basis of recently reported QTL for clinical mastitis.

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publishing date
type
Contribution to journal
publication status
published
in
Journal of Heredity
volume
94
issue
6
pages
11 pages
publisher
Oxford University Press
external identifiers
  • scopus:0347723770
  • pmid:14691316
ISSN
0022-1503
DOI
10.1093/jhered/esg090
language
English
LU publication?
no
id
476f0817-95d0-4310-b914-06af4af71fda
date added to LUP
2018-10-10 13:38:11
date last changed
2024-07-08 21:01:50
@article{476f0817-95d0-4310-b914-06af4af71fda,
  abstract     = {{<p>Genome scans for quantitative trait loci (QTL) in farm animals have concentrated on primary production and health traits, and information on QTL for other important traits is rare. We performed a whole genome scan in a granddaughter design to detect QTL affecting body conformation and behavior in dairy cattle. The analysis included 16 paternal half-sib families of the Holstein breed with 872 sons and 264 genetic markers. The markers were distributed across all 29 autosomes and the pseudoautosomal region of the sex chromosomes with average intervals of 13.9 cM and covering an estimated 3155.5 cM. All families were analyzed jointly for 22 traits using multimarker regression and significance thresholds determined empirically by permutation. QTL that exceeded the experiment-wise significance threshold (5% level) were detected on chromosome 6 for foot angle, teat placement, and under depth, and on chromosome 29 for temperament. QTL approaching experiment-wise significance (10% level) were located on chromosome 6 for general of feet and legs and general quality of under, on chromosome 13 for teat length, on chromosome 23 for general quality of feet and legs, and on chromosome 29 for milking speed. An additional 51 QTL significant at the 5% chromosome-wise level were distributed over 21 chromosomes. This study provides the first evidence for QTL involved in behavior of dairy cattle and identifies QTL for udder conformation on chromosome 6 that could form the basis of recently reported QTL for clinical mastitis.</p>}},
  author       = {{Hiendleder, Stefan and Thomsen, H. and Reinsch, N. and Bennewitz, J. and Leyhe-Horn, B. and Looft, C. and Xu, N. and Medjugorac, I. and Russ, I. and Kühn, C. and Brockmann, G. A. and Blümel, J. and Brenig, B. and Reinhardt, F. and Reents, R. and Averdunk, G. and Schwerin, M. and Förster, M. and Kalm, E. and Erhardt, G.}},
  issn         = {{0022-1503}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{6}},
  pages        = {{496--506}},
  publisher    = {{Oxford University Press}},
  series       = {{Journal of Heredity}},
  title        = {{Mapping of QTL for Body Conformation and Behavior in Cattle}},
  url          = {{http://dx.doi.org/10.1093/jhered/esg090}},
  doi          = {{10.1093/jhered/esg090}},
  volume       = {{94}},
  year         = {{2003}},
}