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Prediagnostic telomere length and risk of B-cell lymphoma-Results from the EPIC cohort study

Hosnijeh, Fatemeh Saberi; Matullo, Giuseppe; Russo, Alessia; Guarrera, Simonetta; Modica, Federica; Nieters, Alexandra; Overvad, Kim; Guldberg, Per; Tjonneland, Anne and Canzian, Federico, et al. (2014) In International Journal of Cancer 135(12). p.2910-2917
Abstract
Recent epidemiological investigations have reported on the association between telomere length (TL) and a number of malignancies, including B-cell lymphoma (BCL). The reported results for BCLs are however inconsistent. We carried out a nested case-control study to determine whether TL is associated with future risk of BCL. Using quantitative polymerase chain reaction, the relative TL (i.e. the ratio of telomere repeat copy number to single gene copy number) was measured in mononuclear cell DNA of prediagnostic peripheral blood samples of 464 lymphoma cases and 464 matched controls (median time between blood collection and diagnosis, 4.6 years). Conditional logistic regression was used to analyze the association between TL and the risk of... (More)
Recent epidemiological investigations have reported on the association between telomere length (TL) and a number of malignancies, including B-cell lymphoma (BCL). The reported results for BCLs are however inconsistent. We carried out a nested case-control study to determine whether TL is associated with future risk of BCL. Using quantitative polymerase chain reaction, the relative TL (i.e. the ratio of telomere repeat copy number to single gene copy number) was measured in mononuclear cell DNA of prediagnostic peripheral blood samples of 464 lymphoma cases and 464 matched controls (median time between blood collection and diagnosis, 4.6 years). Conditional logistic regression was used to analyze the association between TL and the risk of developing lymphoma and histologic subtypes. TL was significantly longer in cases compared to controls (p 5 0.01). Multivariable models showed a significantly increased risk of BCL [odds ratio (OR) = 1.66, 1.80 and 3.20 for quartiles 2-4, respectively, p-trend = 0.001], diffuse large B-cell lymphoma (DLBCL) (OR = 1.20, 2.48 and 2.36 for quartiles 2-4, respectively, p-trend = 0.03) and follicular lymphoma (FL) (OR = 1.39, 1.90 and 2.69 for quartiles 2-4, respectively, p-trend = 0.02) with increasing TL. This study suggests an association between longer leucocyte TL and increased risk of BCL which was most pronounced for DLBCL and FL. (Less)
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publication status
published
subject
keywords
telomeres, lymphoma, NHL, prospective study
in
International Journal of Cancer
volume
135
issue
12
pages
2910 - 2917
publisher
John Wiley & Sons
external identifiers
  • wos:000343055600017
  • scopus:84908666631
ISSN
0020-7136
DOI
10.1002/ijc.28934
language
English
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yes
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c9b8bed4-eed4-44a5-9981-3b5c9e2a40bb (old id 4783990)
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2014-12-01 07:37:00
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2017-09-24 03:19:25
@article{c9b8bed4-eed4-44a5-9981-3b5c9e2a40bb,
  abstract     = {Recent epidemiological investigations have reported on the association between telomere length (TL) and a number of malignancies, including B-cell lymphoma (BCL). The reported results for BCLs are however inconsistent. We carried out a nested case-control study to determine whether TL is associated with future risk of BCL. Using quantitative polymerase chain reaction, the relative TL (i.e. the ratio of telomere repeat copy number to single gene copy number) was measured in mononuclear cell DNA of prediagnostic peripheral blood samples of 464 lymphoma cases and 464 matched controls (median time between blood collection and diagnosis, 4.6 years). Conditional logistic regression was used to analyze the association between TL and the risk of developing lymphoma and histologic subtypes. TL was significantly longer in cases compared to controls (p 5 0.01). Multivariable models showed a significantly increased risk of BCL [odds ratio (OR) = 1.66, 1.80 and 3.20 for quartiles 2-4, respectively, p-trend = 0.001], diffuse large B-cell lymphoma (DLBCL) (OR = 1.20, 2.48 and 2.36 for quartiles 2-4, respectively, p-trend = 0.03) and follicular lymphoma (FL) (OR = 1.39, 1.90 and 2.69 for quartiles 2-4, respectively, p-trend = 0.02) with increasing TL. This study suggests an association between longer leucocyte TL and increased risk of BCL which was most pronounced for DLBCL and FL.},
  author       = {Hosnijeh, Fatemeh Saberi and Matullo, Giuseppe and Russo, Alessia and Guarrera, Simonetta and Modica, Federica and Nieters, Alexandra and Overvad, Kim and Guldberg, Per and Tjonneland, Anne and Canzian, Federico and Boeing, Heiner and Aleksandrova, Krasimira and Trichopoulou, Antonia and Lagiou, Pagona and Trichopoulos, Dimitrios and Tagliabue, Giovanna and Tumino, Rosario and Panico, Salvatore and Palli, Domenico and Olsen, Karina Standahl and Weiderpass, Elisabete and Dorronsoro, Miren and Ardanaz, Eva and Chirlaque, Maria-Dolores and Sanchez, Maria-Jose and Ramon Quiros, J. and Vencesla, Adoracion and Melin, Beatrice and Johansson, Ann Sofie and Nilsson, Peter and Borgquist, Signe and Peeters, Petra H. and Onland-Moret, N. Charlotte and Bueno-de-Mesquita, H. B(as) and Travis, Ruth C. and Khaw, Kay-Tee and Wareham, Nick and Brennan, Paul and Ferrari, Pietro and Gunter, Marc J. and Vineis, Paolo and Vermeulen, Roel},
  issn         = {0020-7136},
  keyword      = {telomeres,lymphoma,NHL,prospective study},
  language     = {eng},
  number       = {12},
  pages        = {2910--2917},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Prediagnostic telomere length and risk of B-cell lymphoma-Results from the EPIC cohort study},
  url          = {http://dx.doi.org/10.1002/ijc.28934},
  volume       = {135},
  year         = {2014},
}