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Anthropometric measures and bladder cancer risk: A prospective study in the EPIC cohort

Roswall, Nina; Freisling, Heinz; Bueno-de-Mesquita, H. B(as); Ros, Martine; Christensen, Jane; Overvad, Kim; Boutron-Ruault, Marie-Christine; Severi, Gianluca; Fagherazzi, Guy and Chang-Claude, Jenny, et al. (2014) In International Journal of Cancer 135(12). p.2918-2929
Abstract
Anthropometric measures have been related to risk of several cancers. For bladder cancer, however, evidence is sparse. Comparability of existing studies is hampered by use of different obesity-measures, inadequate control for smoking, and few female cases. This study examined associations between height, weight, waist and hip circumference, waist-hip ratio, waist-height ratio, body mass index (BMI), recalled weight at age 20 and bladder cancer, and investigated effect modification by age, tumor aggressiveness and smoking. The study was conducted in the European Prospective Investigation into Cancer and Nutrition cohort, in 390,878 participants. Associations were calculated using Cox Proportional Hazards Models. During follow-up, 1,391... (More)
Anthropometric measures have been related to risk of several cancers. For bladder cancer, however, evidence is sparse. Comparability of existing studies is hampered by use of different obesity-measures, inadequate control for smoking, and few female cases. This study examined associations between height, weight, waist and hip circumference, waist-hip ratio, waist-height ratio, body mass index (BMI), recalled weight at age 20 and bladder cancer, and investigated effect modification by age, tumor aggressiveness and smoking. The study was conducted in the European Prospective Investigation into Cancer and Nutrition cohort, in 390,878 participants. Associations were calculated using Cox Proportional Hazards Models. During follow-up, 1,391 bladder cancers (1,018 male; 373 female) occurred. Height was unrelated to bladder cancer in both genders. We found a small but significant positive association with weight [1.04 (1.01-1.07) per 5 kilo], BMI [1.05 (1.02-1.08) per 2 units], waist circumference [1.04 (1.01-1.08) per 5 cm], waist-hip ratio (1.07 (1.02-1.13) per 0.05 unit] and waist-height ratio [1.07 (1.01-1.13) per 0.05 unit] in men. Stratification by smoking status confined associations in men to former smokers. In never smokers, we found no significant associations, suggesting residual confounding by smoking. Results did not differ with tumor aggressiveness and age. Residual analyses on BMI/waist circumference showed a significantly higher disease risk with BMI in men (p=0.01), but no association with waist circumference. In conclusion, in this large study, height was unrelated to bladder cancer, whereas overweight was associated with a slightly higher bladder cancer risk in men. This association may, however, be distorted by residual confounding by smoking. (Less)
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published
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keywords
bladder cancer, anthropometry, obesity, cohort study
in
International Journal of Cancer
volume
135
issue
12
pages
2918 - 2929
publisher
John Wiley & Sons
external identifiers
  • wos:000343055600018
  • scopus:84908680767
ISSN
0020-7136
DOI
10.1002/ijc.28936
language
English
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yes
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8e38a59f-8268-4d64-b9e6-566a229a23ff (old id 4784034)
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2014-12-01 07:36:46
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@article{8e38a59f-8268-4d64-b9e6-566a229a23ff,
  abstract     = {Anthropometric measures have been related to risk of several cancers. For bladder cancer, however, evidence is sparse. Comparability of existing studies is hampered by use of different obesity-measures, inadequate control for smoking, and few female cases. This study examined associations between height, weight, waist and hip circumference, waist-hip ratio, waist-height ratio, body mass index (BMI), recalled weight at age 20 and bladder cancer, and investigated effect modification by age, tumor aggressiveness and smoking. The study was conducted in the European Prospective Investigation into Cancer and Nutrition cohort, in 390,878 participants. Associations were calculated using Cox Proportional Hazards Models. During follow-up, 1,391 bladder cancers (1,018 male; 373 female) occurred. Height was unrelated to bladder cancer in both genders. We found a small but significant positive association with weight [1.04 (1.01-1.07) per 5 kilo], BMI [1.05 (1.02-1.08) per 2 units], waist circumference [1.04 (1.01-1.08) per 5 cm], waist-hip ratio (1.07 (1.02-1.13) per 0.05 unit] and waist-height ratio [1.07 (1.01-1.13) per 0.05 unit] in men. Stratification by smoking status confined associations in men to former smokers. In never smokers, we found no significant associations, suggesting residual confounding by smoking. Results did not differ with tumor aggressiveness and age. Residual analyses on BMI/waist circumference showed a significantly higher disease risk with BMI in men (p=0.01), but no association with waist circumference. In conclusion, in this large study, height was unrelated to bladder cancer, whereas overweight was associated with a slightly higher bladder cancer risk in men. This association may, however, be distorted by residual confounding by smoking.},
  author       = {Roswall, Nina and Freisling, Heinz and Bueno-de-Mesquita, H. B(as) and Ros, Martine and Christensen, Jane and Overvad, Kim and Boutron-Ruault, Marie-Christine and Severi, Gianluca and Fagherazzi, Guy and Chang-Claude, Jenny and Kaaks, Rudolf and Steffen, Annika and Boeing, Heiner and Argueeles, Marcial and Agudo, Antonio and Sanchez, Maria-Jose and Chirlaque, Maria-Dolores and Barricarte Gurrea, Aurelio and Amiano, Pilar and Wareham, Nick and Khaw, Kay-Tee and Bradbury, Kathryn Erica and Trichopoulou, Antonia and Papatesta, Helen-Maria and Trichopoulos, Dimitrios and Palli, Domenico and Pala, Valeria and Tumino, Rosario and Sacerdote, Carlotta and Mattiello, Amalia and Peeters, Petra H. and Ehrnström, Roy and Brennan, Paul and Ferrari, Pietro and Ljungberg, Borje and Norat, Teresa and Gunter, Marc and Riboli, Elio and Weiderpass, Elisabete and Halkjaer, Jytte},
  issn         = {0020-7136},
  keyword      = {bladder cancer,anthropometry,obesity,cohort study},
  language     = {eng},
  number       = {12},
  pages        = {2918--2929},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Anthropometric measures and bladder cancer risk: A prospective study in the EPIC cohort},
  url          = {http://dx.doi.org/10.1002/ijc.28936},
  volume       = {135},
  year         = {2014},
}