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Variations in apolipoprotein D and sigma non-opioid intracellular receptor 1 genes with relation to risk, severity and outcome of ischemic stroke

Lövkvist, Håkan LU ; Jönsson, Ann-Cathrin LU ; Luthman, Holger LU ; Jood, Katarina; Jern, Christina; Wieloch, Tadeusz LU and Lindgren, Arne LU (2014) In BMC Neurology 14.
Abstract
Background: In experimental studies, the apolipoprotein D (APOD) and the sigma receptor type 1 (SIGMAR1) have been related to processes of brain damage, repair and plasticity. Methods: We examined blood samples from 3081 ischemic stroke (IS) patients and 1595 control subjects regarding 10 single nucleotide polymorphisms (SNPs) in the APOD (chromosomal location 3q29) and SIGMAR1 (chromosomal location 9p13) genes to find possible associations with IS risk, IS severity (NIHSS-score) and recovery after IS (modified Rankin Scale, mRS, at 90 days). Simple/multiple logistic regression and Spearman's rho were utilized for the analyses. Results: Among the SNPs analyzed, rs7659 within the APOD gene showed a possible association with stroke risk (OR... (More)
Background: In experimental studies, the apolipoprotein D (APOD) and the sigma receptor type 1 (SIGMAR1) have been related to processes of brain damage, repair and plasticity. Methods: We examined blood samples from 3081 ischemic stroke (IS) patients and 1595 control subjects regarding 10 single nucleotide polymorphisms (SNPs) in the APOD (chromosomal location 3q29) and SIGMAR1 (chromosomal location 9p13) genes to find possible associations with IS risk, IS severity (NIHSS-score) and recovery after IS (modified Rankin Scale, mRS, at 90 days). Simple/multiple logistic regression and Spearman's rho were utilized for the analyses. Results: Among the SNPs analyzed, rs7659 within the APOD gene showed a possible association with stroke risk (OR = 1.12; 95% CI: 1.01-1.25; P = 0.029) and stroke severity (NIHSS >= 16) (OR = 0.70; 95% CI: 0.54-0.92; P = 0.009) when controlling for age, sex and vascular risk factors for stroke. No SNP showed an association with stroke recovery (mRS). Conclusions: We conclude that the SNP rs7659 within the APOD gene might be related to risk and severity of ischemic stroke in patients. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Stroke, Genetics, APOD, SIGMAR1, mRS, NIHSS
in
BMC Neurology
volume
14
publisher
BioMed Central
external identifiers
  • wos:000343254100001
  • scopus:84908082268
ISSN
1471-2377
DOI
10.1186/s12883-014-0191-2
language
English
LU publication?
yes
id
f00168fa-681e-4823-9573-7d8df1da7464 (old id 4790374)
date added to LUP
2014-12-01 07:35:45
date last changed
2017-01-01 05:43:35
@article{f00168fa-681e-4823-9573-7d8df1da7464,
  abstract     = {Background: In experimental studies, the apolipoprotein D (APOD) and the sigma receptor type 1 (SIGMAR1) have been related to processes of brain damage, repair and plasticity. Methods: We examined blood samples from 3081 ischemic stroke (IS) patients and 1595 control subjects regarding 10 single nucleotide polymorphisms (SNPs) in the APOD (chromosomal location 3q29) and SIGMAR1 (chromosomal location 9p13) genes to find possible associations with IS risk, IS severity (NIHSS-score) and recovery after IS (modified Rankin Scale, mRS, at 90 days). Simple/multiple logistic regression and Spearman's rho were utilized for the analyses. Results: Among the SNPs analyzed, rs7659 within the APOD gene showed a possible association with stroke risk (OR = 1.12; 95% CI: 1.01-1.25; P = 0.029) and stroke severity (NIHSS >= 16) (OR = 0.70; 95% CI: 0.54-0.92; P = 0.009) when controlling for age, sex and vascular risk factors for stroke. No SNP showed an association with stroke recovery (mRS). Conclusions: We conclude that the SNP rs7659 within the APOD gene might be related to risk and severity of ischemic stroke in patients.},
  articleno    = {191},
  author       = {Lövkvist, Håkan and Jönsson, Ann-Cathrin and Luthman, Holger and Jood, Katarina and Jern, Christina and Wieloch, Tadeusz and Lindgren, Arne},
  issn         = {1471-2377},
  keyword      = {Stroke,Genetics,APOD,SIGMAR1,mRS,NIHSS},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {BMC Neurology},
  title        = {Variations in apolipoprotein D and sigma non-opioid intracellular receptor 1 genes with relation to risk, severity and outcome of ischemic stroke},
  url          = {http://dx.doi.org/10.1186/s12883-014-0191-2},
  volume       = {14},
  year         = {2014},
}