Variations in apolipoprotein D and sigma non-opioid intracellular receptor 1 genes with relation to risk, severity and outcome of ischemic stroke
(2014) In BMC Neurology 14.- Abstract
- Background: In experimental studies, the apolipoprotein D (APOD) and the sigma receptor type 1 (SIGMAR1) have been related to processes of brain damage, repair and plasticity. Methods: We examined blood samples from 3081 ischemic stroke (IS) patients and 1595 control subjects regarding 10 single nucleotide polymorphisms (SNPs) in the APOD (chromosomal location 3q29) and SIGMAR1 (chromosomal location 9p13) genes to find possible associations with IS risk, IS severity (NIHSS-score) and recovery after IS (modified Rankin Scale, mRS, at 90 days). Simple/multiple logistic regression and Spearman's rho were utilized for the analyses. Results: Among the SNPs analyzed, rs7659 within the APOD gene showed a possible association with stroke risk (OR... (More)
- Background: In experimental studies, the apolipoprotein D (APOD) and the sigma receptor type 1 (SIGMAR1) have been related to processes of brain damage, repair and plasticity. Methods: We examined blood samples from 3081 ischemic stroke (IS) patients and 1595 control subjects regarding 10 single nucleotide polymorphisms (SNPs) in the APOD (chromosomal location 3q29) and SIGMAR1 (chromosomal location 9p13) genes to find possible associations with IS risk, IS severity (NIHSS-score) and recovery after IS (modified Rankin Scale, mRS, at 90 days). Simple/multiple logistic regression and Spearman's rho were utilized for the analyses. Results: Among the SNPs analyzed, rs7659 within the APOD gene showed a possible association with stroke risk (OR = 1.12; 95% CI: 1.01-1.25; P = 0.029) and stroke severity (NIHSS >= 16) (OR = 0.70; 95% CI: 0.54-0.92; P = 0.009) when controlling for age, sex and vascular risk factors for stroke. No SNP showed an association with stroke recovery (mRS). Conclusions: We conclude that the SNP rs7659 within the APOD gene might be related to risk and severity of ischemic stroke in patients. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4790374
- author
- Lövkvist, Håkan LU ; Jönsson, Ann-Cathrin LU ; Luthman, Holger LU ; Jood, Katarina ; Jern, Christina ; Wieloch, Tadeusz LU and Lindgren, Arne LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Stroke, Genetics, APOD, SIGMAR1, mRS, NIHSS
- in
- BMC Neurology
- volume
- 14
- article number
- 191
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000343254100001
- scopus:84908082268
- pmid:25261976
- ISSN
- 1471-2377
- DOI
- 10.1186/s12883-014-0191-2
- language
- English
- LU publication?
- yes
- id
- f00168fa-681e-4823-9573-7d8df1da7464 (old id 4790374)
- date added to LUP
- 2016-04-01 13:32:09
- date last changed
- 2022-02-19 06:01:18
@article{f00168fa-681e-4823-9573-7d8df1da7464,
abstract = {{Background: In experimental studies, the apolipoprotein D (APOD) and the sigma receptor type 1 (SIGMAR1) have been related to processes of brain damage, repair and plasticity. Methods: We examined blood samples from 3081 ischemic stroke (IS) patients and 1595 control subjects regarding 10 single nucleotide polymorphisms (SNPs) in the APOD (chromosomal location 3q29) and SIGMAR1 (chromosomal location 9p13) genes to find possible associations with IS risk, IS severity (NIHSS-score) and recovery after IS (modified Rankin Scale, mRS, at 90 days). Simple/multiple logistic regression and Spearman's rho were utilized for the analyses. Results: Among the SNPs analyzed, rs7659 within the APOD gene showed a possible association with stroke risk (OR = 1.12; 95% CI: 1.01-1.25; P = 0.029) and stroke severity (NIHSS >= 16) (OR = 0.70; 95% CI: 0.54-0.92; P = 0.009) when controlling for age, sex and vascular risk factors for stroke. No SNP showed an association with stroke recovery (mRS). Conclusions: We conclude that the SNP rs7659 within the APOD gene might be related to risk and severity of ischemic stroke in patients.}},
author = {{Lövkvist, Håkan and Jönsson, Ann-Cathrin and Luthman, Holger and Jood, Katarina and Jern, Christina and Wieloch, Tadeusz and Lindgren, Arne}},
issn = {{1471-2377}},
keywords = {{Stroke; Genetics; APOD; SIGMAR1; mRS; NIHSS}},
language = {{eng}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Neurology}},
title = {{Variations in apolipoprotein D and sigma non-opioid intracellular receptor 1 genes with relation to risk, severity and outcome of ischemic stroke}},
url = {{https://lup.lub.lu.se/search/files/3434198/5368500}},
doi = {{10.1186/s12883-014-0191-2}},
volume = {{14}},
year = {{2014}},
}