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Is intermittent androgen-deprivation therapy beneficial for patients with advanced prostate cancer?

Wolff, Johannes M.; Abrahamsson, Per-Anders LU ; Irani, Jacques and da Silva, Fernando Calais (2014) In BJU International 114(4). p.476-483
Abstract
Use of intermittent androgen-deprivation therapy (IADT) in patients with prostate cancer has been evaluated in several studies, in an attempt to delay the development of castration resistance and reduce side-effects associated with ADT. However it is still not clear whether survival is adversely affected in patients treated with IADT. In this review, we explore the available data in an attempt to identify the most suitable candidate patients for IADT, and discuss factors that may inform appropriate patient stratification. ADT is first-line treatment for advanced/metastatic prostate cancer and is also recommended for use with definitive radiotherapy for high-risk localised prostate cancer. The changes in hormone levels induced by ADT can... (More)
Use of intermittent androgen-deprivation therapy (IADT) in patients with prostate cancer has been evaluated in several studies, in an attempt to delay the development of castration resistance and reduce side-effects associated with ADT. However it is still not clear whether survival is adversely affected in patients treated with IADT. In this review, we explore the available data in an attempt to identify the most suitable candidate patients for IADT, and discuss factors that may inform appropriate patient stratification. ADT is first-line treatment for advanced/metastatic prostate cancer and is also recommended for use with definitive radiotherapy for high-risk localised prostate cancer. The changes in hormone levels induced by ADT can lead to short-and long-term side-effects which, although treatable in most cases, can significantly reduce the tolerability of ADT treatment. IADT has been investigated in several phase II and phase III studies in patients with locally advanced or metastatic prostate cancer, in an attempt to delay time to tumour progression and reduce the side-effect burden of ADT. In selected patient groups IADT is no less effective than continuous ADT, ameliorating the impact of ADT-related side-effects, and, to a degree, their impact on patient health-related quality of life (HRQL). Further comparative study is required, particularly in relation to HRQL and long-term complications associated with ADT. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prostate cancer, androgen deprivation, intermittent therapy, prostate-specific antigen, quality of life, survival, testosterone
in
BJU International
volume
114
issue
4
pages
476 - 483
publisher
Blackwell Science Ltd
external identifiers
  • wos:000343007100007
  • scopus:84908135809
ISSN
1464-4096
DOI
10.1111/bju.12626
language
English
LU publication?
yes
id
3485710d-ed71-41fd-b5f3-c67d582f3317 (old id 4796322)
date added to LUP
2014-12-01 07:32:41
date last changed
2017-03-19 03:16:23
@article{3485710d-ed71-41fd-b5f3-c67d582f3317,
  abstract     = {Use of intermittent androgen-deprivation therapy (IADT) in patients with prostate cancer has been evaluated in several studies, in an attempt to delay the development of castration resistance and reduce side-effects associated with ADT. However it is still not clear whether survival is adversely affected in patients treated with IADT. In this review, we explore the available data in an attempt to identify the most suitable candidate patients for IADT, and discuss factors that may inform appropriate patient stratification. ADT is first-line treatment for advanced/metastatic prostate cancer and is also recommended for use with definitive radiotherapy for high-risk localised prostate cancer. The changes in hormone levels induced by ADT can lead to short-and long-term side-effects which, although treatable in most cases, can significantly reduce the tolerability of ADT treatment. IADT has been investigated in several phase II and phase III studies in patients with locally advanced or metastatic prostate cancer, in an attempt to delay time to tumour progression and reduce the side-effect burden of ADT. In selected patient groups IADT is no less effective than continuous ADT, ameliorating the impact of ADT-related side-effects, and, to a degree, their impact on patient health-related quality of life (HRQL). Further comparative study is required, particularly in relation to HRQL and long-term complications associated with ADT.},
  author       = {Wolff, Johannes M. and Abrahamsson, Per-Anders and Irani, Jacques and da Silva, Fernando Calais},
  issn         = {1464-4096},
  keyword      = {prostate cancer,androgen deprivation,intermittent therapy,prostate-specific antigen,quality of life,survival,testosterone},
  language     = {eng},
  number       = {4},
  pages        = {476--483},
  publisher    = {Blackwell Science Ltd},
  series       = {BJU International},
  title        = {Is intermittent androgen-deprivation therapy beneficial for patients with advanced prostate cancer?},
  url          = {http://dx.doi.org/10.1111/bju.12626},
  volume       = {114},
  year         = {2014},
}