Prediagnostic Circulating Vitamin D Levels and Risk of Hepatocellular Carcinoma in European Populations: A Nested Case-Control Study
(2014) In Hepatology 60(4). p.1222-1230- Abstract
- The association between vitamin D status and hepatocellular carcinoma (HCC) has not been well investigated, despite experimental evidence supporting an important role of vitamin D in liver pathophysiology. Our objective was to investigate the association between prediagnostic circulating 25-hydroxyvitamin D [25(OH)D] serum levels and the risk of HCC in a prospective, nested case-control study among 520,000 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Each case (n=138) diagnosed between 1992 and 2010 was matched to one control by age, sex, study center, date and time of blood collection, and fasting status. Serum baseline levels of 25(OH)D were measured by liquid chromatography/tandem mass... (More)
- The association between vitamin D status and hepatocellular carcinoma (HCC) has not been well investigated, despite experimental evidence supporting an important role of vitamin D in liver pathophysiology. Our objective was to investigate the association between prediagnostic circulating 25-hydroxyvitamin D [25(OH)D] serum levels and the risk of HCC in a prospective, nested case-control study among 520,000 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Each case (n=138) diagnosed between 1992 and 2010 was matched to one control by age, sex, study center, date and time of blood collection, and fasting status. Serum baseline levels of 25(OH)D were measured by liquid chromatography/tandem mass spectrometry. Multivariable incident rate ratios (IRRs) of HCC associated with continuous (per 10 nmol/L) or categorical levels (tertiles or a priori-defined categories) of prediagnostic 25(OH)D were calculated using conditional logistic regression. Higher 25(OH)D levels were associated with a 49% reduction in the risk of HCC (highest versus lowest tertile: multivariable IRR=0.51, 95% confidence interval [CI], 0.26 to 0.99; P-trend=0.04; per 10 nmol/L increase: IRR=0.80, 95% CI, 0.68-0.94). The finding did not vary substantially by time from enrolment to diagnosis, and did not change after adjustment for biomarkers of preexisting liver damage, nor chronic infection with hepatitis B or C viruses. The findings were not modified by body size or smoking status. Conclusion: In this prospective study on western European populations, serum levels of 25(OH)D were inversely associated with the risk of HCC. Given the rising incidence of this cancer in low-risk developed countries and the strong public health interest surrounding the potentially cancer-protective roles of vitamin D, additional studies in different populations are required. (Hepatology 2014;60:1222-1230) (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4796342
- author
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Hepatology
- volume
- 60
- issue
- 4
- pages
- 1222 - 1230
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000342662100015
- pmid:24644045
- scopus:84927724482
- ISSN
- 1527-3350
- DOI
- 10.1002/hep.27079
- language
- English
- LU publication?
- yes
- id
- c3df05e2-9d4a-425a-b868-261985678898 (old id 4796342)
- date added to LUP
- 2016-04-01 13:58:48
- date last changed
- 2022-04-06 08:12:44
@article{c3df05e2-9d4a-425a-b868-261985678898,
abstract = {{The association between vitamin D status and hepatocellular carcinoma (HCC) has not been well investigated, despite experimental evidence supporting an important role of vitamin D in liver pathophysiology. Our objective was to investigate the association between prediagnostic circulating 25-hydroxyvitamin D [25(OH)D] serum levels and the risk of HCC in a prospective, nested case-control study among 520,000 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Each case (n=138) diagnosed between 1992 and 2010 was matched to one control by age, sex, study center, date and time of blood collection, and fasting status. Serum baseline levels of 25(OH)D were measured by liquid chromatography/tandem mass spectrometry. Multivariable incident rate ratios (IRRs) of HCC associated with continuous (per 10 nmol/L) or categorical levels (tertiles or a priori-defined categories) of prediagnostic 25(OH)D were calculated using conditional logistic regression. Higher 25(OH)D levels were associated with a 49% reduction in the risk of HCC (highest versus lowest tertile: multivariable IRR=0.51, 95% confidence interval [CI], 0.26 to 0.99; P-trend=0.04; per 10 nmol/L increase: IRR=0.80, 95% CI, 0.68-0.94). The finding did not vary substantially by time from enrolment to diagnosis, and did not change after adjustment for biomarkers of preexisting liver damage, nor chronic infection with hepatitis B or C viruses. The findings were not modified by body size or smoking status. Conclusion: In this prospective study on western European populations, serum levels of 25(OH)D were inversely associated with the risk of HCC. Given the rising incidence of this cancer in low-risk developed countries and the strong public health interest surrounding the potentially cancer-protective roles of vitamin D, additional studies in different populations are required. (Hepatology 2014;60:1222-1230)}},
author = {{Fedirko, Veronika and Duarte-Salles, Talita and Bamia, Christina and Trichopoulou, Antonia and Aleksandrova, Krasimira and Trichopoulos, Dimitrios and Trepo, Elisabeth and Tjonneland, Anne and Olsen, Anja and Overvad, Kim and Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise and Kvaskoff, Marina and Kuehn, Tilman and Lukanova, Annie and Boeing, Heiner and Buijsse, Brian and Klinaki, Eleni and Tsimakidi, Chrysanthi and Naccarati, Alessio and Tagliabue, Giovanna and Panico, Salvatore and Tumino, Rosario and Palli, Domenico and Bueno-de-Mesquita, H. Bas and Siersema, Peter D. and Peters, Petra H. and Lund, Eiliv and Brustad, Magritt and Olsen, Karina Standahl and Weiderpass, Elisabete and Zamora-Ros, Raul and Sanchez, Maria-Jose and Ardanaz, Eva and Amiano, Pilar and Navarro, Carmen and Ramon Quiros, J. and Werner, Marten and Sund, Malin and Lindkvist, Bjorn and Malm, Johan and Travis, Ruth C. and Khaw, Kay-Tee and Stepien, Magdalena and Scalbert, Augustin and Romieu, Isabelle and Lagiou, Pagona and Riboli, Elio and Jenab, Mazda}},
issn = {{1527-3350}},
language = {{eng}},
number = {{4}},
pages = {{1222--1230}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Hepatology}},
title = {{Prediagnostic Circulating Vitamin D Levels and Risk of Hepatocellular Carcinoma in European Populations: A Nested Case-Control Study}},
url = {{http://dx.doi.org/10.1002/hep.27079}},
doi = {{10.1002/hep.27079}},
volume = {{60}},
year = {{2014}},
}