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HLA, infections and inflammation in early stages of atherosclerosis in children with type 1 diabetes

Odermarsky, Michal LU orcid ; Pesonen, Erkki LU ; Sorsa, Timo ; Lernmark, Åke LU orcid ; Pussinen, Pirkko and Liuba, Petru LU (2018) In Acta Diabetologica 55(1). p.41-47
Abstract
Aims

This prospective study focuses on risk factors for arterial damage in children with type 1 diabetes (T1D).
Methods

Eighty children and adolescents with T1D were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. All subjects were genotyped for HLA. The number of respiratory tract infections (RTI) during the past year was obtained by a questionnaire in 56 patients.
Results

cIMT progression, defined as percentage (%) change of cIMT from baseline, correlated inversely with the % changes of both CAC (p = 0.04, r = − 0.3; n = 62)... (More)
Aims

This prospective study focuses on risk factors for arterial damage in children with type 1 diabetes (T1D).
Methods

Eighty children and adolescents with T1D were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. All subjects were genotyped for HLA. The number of respiratory tract infections (RTI) during the past year was obtained by a questionnaire in 56 patients.
Results

cIMT progression, defined as percentage (%) change of cIMT from baseline, correlated inversely with the % changes of both CAC (p = 0.04, r = − 0.3; n = 62) and FMD (p = 0.03, r = − 0.3; n = 47). In multivariate analysis, RTI frequency correlated significantly with cIMT progression irrespective of age, diabetes duration, BMI, and HbA1c (p = 0.03, r = 0.3). When patients were divided in relation to RTI, the association of DQ2/8 with cIMT progression remained significant in patients with over three infections/year (p = 0.04, r = 0.3). During follow-up, the group of DQ2/8 patients with hsCRP > 1 mg/l showed significantly higher levels of plasma MMP-8 than the non-DQ2/8 group.
Conclusions

The diabetes-risk genotype DQ2/8 and systemic inflammation contribute to pro-atherosclerotic vascular changes in children and adolescents with T1D. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Diabetologica
volume
55
issue
1
pages
7 pages
publisher
Springer
external identifiers
  • scopus:85031995595
  • pmid:29064046
ISSN
1432-5233
DOI
10.1007/s00592-017-1063-1
language
English
LU publication?
yes
id
47b9d9bd-5a73-4a33-9750-3b8590dd6905
date added to LUP
2017-10-24 14:41:31
date last changed
2022-03-09 06:57:10
@article{47b9d9bd-5a73-4a33-9750-3b8590dd6905,
  abstract     = {{Aims<br>
<br>
This prospective study focuses on risk factors for arterial damage in children with type 1 diabetes (T1D).<br>
Methods<br>
<br>
Eighty children and adolescents with T1D were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. All subjects were genotyped for HLA. The number of respiratory tract infections (RTI) during the past year was obtained by a questionnaire in 56 patients.<br>
Results<br>
<br>
cIMT progression, defined as percentage (%) change of cIMT from baseline, correlated inversely with the % changes of both CAC (p = 0.04, r = − 0.3; n = 62) and FMD (p = 0.03, r = − 0.3; n = 47). In multivariate analysis, RTI frequency correlated significantly with cIMT progression irrespective of age, diabetes duration, BMI, and HbA1c (p = 0.03, r = 0.3). When patients were divided in relation to RTI, the association of DQ2/8 with cIMT progression remained significant in patients with over three infections/year (p = 0.04, r = 0.3). During follow-up, the group of DQ2/8 patients with hsCRP &gt; 1 mg/l showed significantly higher levels of plasma MMP-8 than the non-DQ2/8 group.<br>
Conclusions<br>
<br>
The diabetes-risk genotype DQ2/8 and systemic inflammation contribute to pro-atherosclerotic vascular changes in children and adolescents with T1D.}},
  author       = {{Odermarsky, Michal and Pesonen, Erkki and Sorsa, Timo and Lernmark, Åke and Pussinen, Pirkko and Liuba, Petru}},
  issn         = {{1432-5233}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{41--47}},
  publisher    = {{Springer}},
  series       = {{Acta Diabetologica}},
  title        = {{HLA, infections and inflammation in early stages of atherosclerosis in children with type 1 diabetes}},
  url          = {{http://dx.doi.org/10.1007/s00592-017-1063-1}},
  doi          = {{10.1007/s00592-017-1063-1}},
  volume       = {{55}},
  year         = {{2018}},
}