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The incidence of a first major osteoporotic fracture in Iceland and implications for FRAX

Siggeirsdottir, K.; Aspelund, T.; Johansson, H.; Gudmundsson, E. F.; Mogensen, B.; Jonsson, Brynjolfur LU ; Gudnason, V.; McCloskey, E.; Oden, A. and Sigurdsson, G., et al. (2014) In Osteoporosis International 25(10). p.2445-2451
Abstract
Based on an extensive cohort study over 25 years, the present study supports the assumption that major osteoporotic fractures can be reasonably predicted from hip fracture rates. The construct for FRAX models depends on algorithms to adjust for double counting of fracture outcomes in some models and in others, to estimate the incidence of a major fracture from hip fracture rates. The aim of the present study was to test the validity of these algorithms in a large prospective cohort. The incidence of hip, clinical spine, distal forearm, and humerus fracture was determined in the prospective and ongoing population-based Reykjavik Study with follow up of 257,001 person-years. The incidence of a first major fracture was compared with the... (More)
Based on an extensive cohort study over 25 years, the present study supports the assumption that major osteoporotic fractures can be reasonably predicted from hip fracture rates. The construct for FRAX models depends on algorithms to adjust for double counting of fracture outcomes in some models and in others, to estimate the incidence of a major fracture from hip fracture rates. The aim of the present study was to test the validity of these algorithms in a large prospective cohort. The incidence of hip, clinical spine, distal forearm, and humerus fracture was determined in the prospective and ongoing population-based Reykjavik Study with follow up of 257,001 person-years. The incidence of a first major fracture was compared with the correction factors used in FRAX to adjust the incidence of several fracture outcomes for double counting. In addition, the incidence of a major osteoporotic fracture estimated from the Icelandic hip fracture rates was compared with the Malmo ratios used in FRAX. The adjustments necessary to account for multiple fracture outcomes were similar to those previously derived from Sweden. Additionally, incidence of a first major osteoporotic fracture was similar to that derived for FRAX models. The findings of the present study support the algorithms used in FRAX to estimate the incidence of a first major fracture and the predictive value of hip fracture for other major fractures. (Less)
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publication status
published
subject
keywords
Fracture incidence, FRAX, Major osteoporotic fracture
in
Osteoporosis International
volume
25
issue
10
pages
2445 - 2451
publisher
Springer
external identifiers
  • wos:000342438800011
  • scopus:84919448789
ISSN
1433-2965
DOI
10.1007/s00198-014-2777-3
language
English
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yes
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3a66b70e-bcbc-4e5a-a235-1ee47ca78679 (old id 4803488)
date added to LUP
2014-12-01 07:34:41
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2017-11-19 03:45:47
@article{3a66b70e-bcbc-4e5a-a235-1ee47ca78679,
  abstract     = {Based on an extensive cohort study over 25 years, the present study supports the assumption that major osteoporotic fractures can be reasonably predicted from hip fracture rates. The construct for FRAX models depends on algorithms to adjust for double counting of fracture outcomes in some models and in others, to estimate the incidence of a major fracture from hip fracture rates. The aim of the present study was to test the validity of these algorithms in a large prospective cohort. The incidence of hip, clinical spine, distal forearm, and humerus fracture was determined in the prospective and ongoing population-based Reykjavik Study with follow up of 257,001 person-years. The incidence of a first major fracture was compared with the correction factors used in FRAX to adjust the incidence of several fracture outcomes for double counting. In addition, the incidence of a major osteoporotic fracture estimated from the Icelandic hip fracture rates was compared with the Malmo ratios used in FRAX. The adjustments necessary to account for multiple fracture outcomes were similar to those previously derived from Sweden. Additionally, incidence of a first major osteoporotic fracture was similar to that derived for FRAX models. The findings of the present study support the algorithms used in FRAX to estimate the incidence of a first major fracture and the predictive value of hip fracture for other major fractures.},
  author       = {Siggeirsdottir, K. and Aspelund, T. and Johansson, H. and Gudmundsson, E. F. and Mogensen, B. and Jonsson, Brynjolfur and Gudnason, V. and McCloskey, E. and Oden, A. and Sigurdsson, G. and Kanis, J. A.},
  issn         = {1433-2965},
  keyword      = {Fracture incidence,FRAX,Major osteoporotic fracture},
  language     = {eng},
  number       = {10},
  pages        = {2445--2451},
  publisher    = {Springer},
  series       = {Osteoporosis International},
  title        = {The incidence of a first major osteoporotic fracture in Iceland and implications for FRAX},
  url          = {http://dx.doi.org/10.1007/s00198-014-2777-3},
  volume       = {25},
  year         = {2014},
}