Effect of cardiovascular drugs on mortality in atrial fibrillation and chronic heart failure
(2014) In Scandinavian Cardiovascular Journal 48(5). p.291-298- Abstract
- Objectives. To study mortality rates among men and women with atrial fibrillation (AF) and concomitant chronic heart failure (CHF) prescribed different classes of cardiovascular drugs in primary health care. Design. A cohort of men (n = 1159) and women (n = 1155) aged 45 years or above and diagnosed with both AF and CHF from patient records from 75 primary care centers in Sweden were included in the study. Regression models with mortality as the outcome were used, with adjustment for a propensity score comprising age, cardiovascular co-morbidities, education, marital status, and pharmacotherapy. We analysed using Cox regression with hazard ratio (HR), and Laplace regression with years until 10% of the patients had died, with 95% confi... (More)
- Objectives. To study mortality rates among men and women with atrial fibrillation (AF) and concomitant chronic heart failure (CHF) prescribed different classes of cardiovascular drugs in primary health care. Design. A cohort of men (n = 1159) and women (n = 1155) aged 45 years or above and diagnosed with both AF and CHF from patient records from 75 primary care centers in Sweden were included in the study. Regression models with mortality as the outcome were used, with adjustment for a propensity score comprising age, cardiovascular co-morbidities, education, marital status, and pharmacotherapy. We analysed using Cox regression with hazard ratio (HR), and Laplace regression with years until 10% of the patients had died, with 95% confi dence intervals (95% CI). Independent variables were prescribed cardiovascular drugs. Results. Individuals prescribed anticoagulants versus no treatment gained 1.95 years (95% CI 0.47-3.43), anticoagulants versus antiplatelets 1.26 years (95% CI 0.42-2.10), calcium channel blockers 1.17 years (95% CI 0.21-2.14), and statins 1.49 years (95% CI 0.39-2.59). Among patients 80 years or above no significant effect by anticoagulants was seen, HR 0.73 (95% CI 0.43-1.23). Conclusions. Our findings suggest that life may be prolonged in patients with AF and concomitant CHF in primary care prescribed anticoagulants, calcium channel blockers, and statins. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4803809
- author
- Wandell, Per ; Carlsson, Axel C. ; Sundquist, Jan LU ; Johansson, Sven-Erik LU ; Bottai, Matteo and Sundquist, Kristina LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- antithrombotic drugs, follow-up, gender, mortality, pharmacotherapy, propensity score, statins
- in
- Scandinavian Cardiovascular Journal
- volume
- 48
- issue
- 5
- pages
- 291 - 298
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000342346300007
- scopus:84907247335
- ISSN
- 1651-2006
- DOI
- 10.3109/14017431.2014.941002
- language
- English
- LU publication?
- yes
- id
- ed85fb54-f8af-4c69-b7e5-2bdbda228f9a (old id 4803809)
- date added to LUP
- 2016-04-01 14:31:54
- date last changed
- 2022-03-14 06:21:05
@article{ed85fb54-f8af-4c69-b7e5-2bdbda228f9a,
abstract = {{Objectives. To study mortality rates among men and women with atrial fibrillation (AF) and concomitant chronic heart failure (CHF) prescribed different classes of cardiovascular drugs in primary health care. Design. A cohort of men (n = 1159) and women (n = 1155) aged 45 years or above and diagnosed with both AF and CHF from patient records from 75 primary care centers in Sweden were included in the study. Regression models with mortality as the outcome were used, with adjustment for a propensity score comprising age, cardiovascular co-morbidities, education, marital status, and pharmacotherapy. We analysed using Cox regression with hazard ratio (HR), and Laplace regression with years until 10% of the patients had died, with 95% confi dence intervals (95% CI). Independent variables were prescribed cardiovascular drugs. Results. Individuals prescribed anticoagulants versus no treatment gained 1.95 years (95% CI 0.47-3.43), anticoagulants versus antiplatelets 1.26 years (95% CI 0.42-2.10), calcium channel blockers 1.17 years (95% CI 0.21-2.14), and statins 1.49 years (95% CI 0.39-2.59). Among patients 80 years or above no significant effect by anticoagulants was seen, HR 0.73 (95% CI 0.43-1.23). Conclusions. Our findings suggest that life may be prolonged in patients with AF and concomitant CHF in primary care prescribed anticoagulants, calcium channel blockers, and statins.}},
author = {{Wandell, Per and Carlsson, Axel C. and Sundquist, Jan and Johansson, Sven-Erik and Bottai, Matteo and Sundquist, Kristina}},
issn = {{1651-2006}},
keywords = {{antithrombotic drugs; follow-up; gender; mortality; pharmacotherapy; propensity score; statins}},
language = {{eng}},
number = {{5}},
pages = {{291--298}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Cardiovascular Journal}},
title = {{Effect of cardiovascular drugs on mortality in atrial fibrillation and chronic heart failure}},
url = {{http://dx.doi.org/10.3109/14017431.2014.941002}},
doi = {{10.3109/14017431.2014.941002}},
volume = {{48}},
year = {{2014}},
}