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Effect of cardiovascular drugs on mortality in atrial fibrillation and chronic heart failure

Wandell, Per; Carlsson, Axel C.; Sundquist, Jan LU ; Johansson, Sven-Erik LU ; Bottai, Matteo and Sundquist, Kristina LU (2014) In Scandinavian Cardiovascular Journal 48(5). p.291-298
Abstract
Objectives. To study mortality rates among men and women with atrial fibrillation (AF) and concomitant chronic heart failure (CHF) prescribed different classes of cardiovascular drugs in primary health care. Design. A cohort of men (n = 1159) and women (n = 1155) aged 45 years or above and diagnosed with both AF and CHF from patient records from 75 primary care centers in Sweden were included in the study. Regression models with mortality as the outcome were used, with adjustment for a propensity score comprising age, cardiovascular co-morbidities, education, marital status, and pharmacotherapy. We analysed using Cox regression with hazard ratio (HR), and Laplace regression with years until 10% of the patients had died, with 95% confi... (More)
Objectives. To study mortality rates among men and women with atrial fibrillation (AF) and concomitant chronic heart failure (CHF) prescribed different classes of cardiovascular drugs in primary health care. Design. A cohort of men (n = 1159) and women (n = 1155) aged 45 years or above and diagnosed with both AF and CHF from patient records from 75 primary care centers in Sweden were included in the study. Regression models with mortality as the outcome were used, with adjustment for a propensity score comprising age, cardiovascular co-morbidities, education, marital status, and pharmacotherapy. We analysed using Cox regression with hazard ratio (HR), and Laplace regression with years until 10% of the patients had died, with 95% confi dence intervals (95% CI). Independent variables were prescribed cardiovascular drugs. Results. Individuals prescribed anticoagulants versus no treatment gained 1.95 years (95% CI 0.47-3.43), anticoagulants versus antiplatelets 1.26 years (95% CI 0.42-2.10), calcium channel blockers 1.17 years (95% CI 0.21-2.14), and statins 1.49 years (95% CI 0.39-2.59). Among patients 80 years or above no significant effect by anticoagulants was seen, HR 0.73 (95% CI 0.43-1.23). Conclusions. Our findings suggest that life may be prolonged in patients with AF and concomitant CHF in primary care prescribed anticoagulants, calcium channel blockers, and statins. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antithrombotic drugs, follow-up, gender, mortality, pharmacotherapy, propensity score, statins
in
Scandinavian Cardiovascular Journal
volume
48
issue
5
pages
291 - 298
publisher
Taylor & Francis
external identifiers
  • wos:000342346300007
  • scopus:84907247335
ISSN
1651-2006
DOI
10.3109/14017431.2014.941002
language
English
LU publication?
yes
id
ed85fb54-f8af-4c69-b7e5-2bdbda228f9a (old id 4803809)
date added to LUP
2014-12-01 07:38:17
date last changed
2017-01-01 06:17:29
@article{ed85fb54-f8af-4c69-b7e5-2bdbda228f9a,
  abstract     = {Objectives. To study mortality rates among men and women with atrial fibrillation (AF) and concomitant chronic heart failure (CHF) prescribed different classes of cardiovascular drugs in primary health care. Design. A cohort of men (n = 1159) and women (n = 1155) aged 45 years or above and diagnosed with both AF and CHF from patient records from 75 primary care centers in Sweden were included in the study. Regression models with mortality as the outcome were used, with adjustment for a propensity score comprising age, cardiovascular co-morbidities, education, marital status, and pharmacotherapy. We analysed using Cox regression with hazard ratio (HR), and Laplace regression with years until 10% of the patients had died, with 95% confi dence intervals (95% CI). Independent variables were prescribed cardiovascular drugs. Results. Individuals prescribed anticoagulants versus no treatment gained 1.95 years (95% CI 0.47-3.43), anticoagulants versus antiplatelets 1.26 years (95% CI 0.42-2.10), calcium channel blockers 1.17 years (95% CI 0.21-2.14), and statins 1.49 years (95% CI 0.39-2.59). Among patients 80 years or above no significant effect by anticoagulants was seen, HR 0.73 (95% CI 0.43-1.23). Conclusions. Our findings suggest that life may be prolonged in patients with AF and concomitant CHF in primary care prescribed anticoagulants, calcium channel blockers, and statins.},
  author       = {Wandell, Per and Carlsson, Axel C. and Sundquist, Jan and Johansson, Sven-Erik and Bottai, Matteo and Sundquist, Kristina},
  issn         = {1651-2006},
  keyword      = {antithrombotic drugs,follow-up,gender,mortality,pharmacotherapy,propensity score,statins},
  language     = {eng},
  number       = {5},
  pages        = {291--298},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Cardiovascular Journal},
  title        = {Effect of cardiovascular drugs on mortality in atrial fibrillation and chronic heart failure},
  url          = {http://dx.doi.org/10.3109/14017431.2014.941002},
  volume       = {48},
  year         = {2014},
}