Advanced

Serum Estradiol Levels Are Inversely Associated With Cortical Porosity in Older Men

Vandenput, Liesbeth; Lorentzon, Mattias; Sundh, Daniel; Nilsson, Maria E.; Karlsson, Magnus LU ; Mellstrom, Dan and Ohlsson, Claes (2014) In Journal of Clinical Endocrinology and Metabolism 99(7). p.1322-1326
Abstract
Context: The key role of serum estradiol (E2) for bone health in men is well established. The effect of serum sex steroids on bone microstructure, measured by high-resolution peripheral quantitative computed tomography, remains unknown in elderly men. Objective: The objective of the study was to examine the associations between serum sex steroids and bone microstructural parameters in older men. Methods: Trabecular and cortical bone microstructure at the tibia was measured by high-resolution peripheral quantitative computed tomography in 440 men (mean 80 y of age) participating in the population-based Osteoporotic Fractures in Men Sweden cohort. Serum levels of E2 and T were analyzed with mass spectrometry and free E2 and free T levels... (More)
Context: The key role of serum estradiol (E2) for bone health in men is well established. The effect of serum sex steroids on bone microstructure, measured by high-resolution peripheral quantitative computed tomography, remains unknown in elderly men. Objective: The objective of the study was to examine the associations between serum sex steroids and bone microstructural parameters in older men. Methods: Trabecular and cortical bone microstructure at the tibia was measured by high-resolution peripheral quantitative computed tomography in 440 men (mean 80 y of age) participating in the population-based Osteoporotic Fractures in Men Sweden cohort. Serum levels of E2 and T were analyzed with mass spectrometry and free E2 and free T levels were calculated using law-of-mass-action equations. Results: Age-adjusted models demonstrated that E2 and free E2 but not T or free T associated significantly inversely with cortical porosity. The associations between E2 and free E2 and cortical porosity remained significant after further adjustment for height, weight, physical activity, calcium intake, and smoking. Models including both serum E2 and T demonstrated that E2 (standardized beta = -.12, P < .05) but not T associated independently with cortical porosity. A similar independent association was found for free E2 (standardized beta = -.12, P < .05) but not free T. Free E2 associated significantly with trabecular bone volume fraction in the age-adjusted models, but this association did not remain significant after further adjustment. Conclusions: Serum E2 levels associated inversely with cortical porosity in 80-year-old men. We propose that low serum E2 may reduce cortical bone strength, at least partly, by increasing cortical porosity and thereby increase fracture risk in older men. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Endocrinology and Metabolism
volume
99
issue
7
pages
1322 - 1326
publisher
The Endocrine Society
external identifiers
  • wos:000342341000022
  • scopus:84904048051
ISSN
1945-7197
DOI
10.1210/jc.2014-1319
language
English
LU publication?
yes
id
e4559144-924b-4c10-b6dc-db8a4a2bbd2a (old id 4810201)
date added to LUP
2014-12-01 07:39:52
date last changed
2017-08-06 04:03:34
@article{e4559144-924b-4c10-b6dc-db8a4a2bbd2a,
  abstract     = {Context: The key role of serum estradiol (E2) for bone health in men is well established. The effect of serum sex steroids on bone microstructure, measured by high-resolution peripheral quantitative computed tomography, remains unknown in elderly men. Objective: The objective of the study was to examine the associations between serum sex steroids and bone microstructural parameters in older men. Methods: Trabecular and cortical bone microstructure at the tibia was measured by high-resolution peripheral quantitative computed tomography in 440 men (mean 80 y of age) participating in the population-based Osteoporotic Fractures in Men Sweden cohort. Serum levels of E2 and T were analyzed with mass spectrometry and free E2 and free T levels were calculated using law-of-mass-action equations. Results: Age-adjusted models demonstrated that E2 and free E2 but not T or free T associated significantly inversely with cortical porosity. The associations between E2 and free E2 and cortical porosity remained significant after further adjustment for height, weight, physical activity, calcium intake, and smoking. Models including both serum E2 and T demonstrated that E2 (standardized beta = -.12, P &lt; .05) but not T associated independently with cortical porosity. A similar independent association was found for free E2 (standardized beta = -.12, P &lt; .05) but not free T. Free E2 associated significantly with trabecular bone volume fraction in the age-adjusted models, but this association did not remain significant after further adjustment. Conclusions: Serum E2 levels associated inversely with cortical porosity in 80-year-old men. We propose that low serum E2 may reduce cortical bone strength, at least partly, by increasing cortical porosity and thereby increase fracture risk in older men.},
  author       = {Vandenput, Liesbeth and Lorentzon, Mattias and Sundh, Daniel and Nilsson, Maria E. and Karlsson, Magnus and Mellstrom, Dan and Ohlsson, Claes},
  issn         = {1945-7197},
  language     = {eng},
  number       = {7},
  pages        = {1322--1326},
  publisher    = {The Endocrine Society},
  series       = {Journal of Clinical Endocrinology and Metabolism},
  title        = {Serum Estradiol Levels Are Inversely Associated With Cortical Porosity in Older Men},
  url          = {http://dx.doi.org/10.1210/jc.2014-1319},
  volume       = {99},
  year         = {2014},
}