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Clinical Correlations With Lewy Body Pathology in LRRK2-Related Parkinson Disease.

Kalia, Lorraine V; Lang, Anthony E; Hazrati, Lili-Naz; Fujioka, Shinsuke; Wszolek, Zbigniew K; Dickson, Dennis W; Ross, Owen A; Van Deerlin, Vivianna M; Trojanowski, John Q and Hurtig, Howard I, et al. (2015) In JAMA Neurology 72(1). p.100-105
Abstract
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of genetic Parkinson disease (PD) known to date. The clinical features of manifesting LRRK2 mutation carriers are generally indistinguishable from those of patients with sporadic PD. However, some PD cases associated with LRRK2 mutations lack Lewy bodies (LBs), a neuropathological hallmark of PD. We investigated whether the presence or absence of LBs correlates with different clinical features in LRRK2-related PD.
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Contribution to journal
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JAMA Neurology
volume
72
issue
1
pages
100 - 105
publisher
American Medical Association
external identifiers
  • pmid:25401511
  • wos:000347815300016
  • scopus:84921033215
ISSN
2168-6157
DOI
10.1001/jamaneurol.2014.2704
language
English
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yes
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b22c57e8-d69a-41aa-ab8d-bbbd1398305b (old id 4816480)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25401511?dopt=Abstract
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399368/pdf/nihms-678094.pdf
date added to LUP
2014-12-02 18:47:42
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2017-11-05 03:12:21
@article{b22c57e8-d69a-41aa-ab8d-bbbd1398305b,
  abstract     = {Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of genetic Parkinson disease (PD) known to date. The clinical features of manifesting LRRK2 mutation carriers are generally indistinguishable from those of patients with sporadic PD. However, some PD cases associated with LRRK2 mutations lack Lewy bodies (LBs), a neuropathological hallmark of PD. We investigated whether the presence or absence of LBs correlates with different clinical features in LRRK2-related PD.},
  author       = {Kalia, Lorraine V and Lang, Anthony E and Hazrati, Lili-Naz and Fujioka, Shinsuke and Wszolek, Zbigniew K and Dickson, Dennis W and Ross, Owen A and Van Deerlin, Vivianna M and Trojanowski, John Q and Hurtig, Howard I and Alcalay, Roy N and Marder, Karen S and Clark, Lorraine N and Gaig, Carles and Tolosa, Eduardo and Ruiz-Martínez, Javier and Marti-Masso, Jose F and Ferrer, Isidre and López de Munain, Adolfo and Goldman, Samuel M and Schüle, Birgitt and Langston, J William and Aasly, Jan O and Giordana, Maria T and Bonifati, Vincenzo and Puschmann, Andreas and Canesi, Margherita and Pezzoli, Gianni and Maues De Paula, Andre and Hasegawa, Kazuko and Duyckaerts, Charles and Brice, Alexis and Stoessl, A Jon and Marras, Connie},
  issn         = {2168-6157},
  language     = {eng},
  number       = {1},
  pages        = {100--105},
  publisher    = {American Medical Association},
  series       = {JAMA Neurology},
  title        = {Clinical Correlations With Lewy Body Pathology in LRRK2-Related Parkinson Disease.},
  url          = {http://dx.doi.org/10.1001/jamaneurol.2014.2704},
  volume       = {72},
  year         = {2015},
}