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Immune checkpoint therapy for pancreatic cancer

Johansson, Henrik; Andersson, Roland LU ; Bauden, Monika LU ; Hammes, Sarah; Holdenrieder, Stefan and Ansari, Daniel LU (2016) In World Journal of Gastroenterology 22(43). p.9457-9476
Abstract

Novel treatment modalities are necessary for pancreatic cancer. Immunotherapy with immune checkpoint inhibition has shown effect in other solid tumors, and could have a place in pancreatic cancer treatment. Most available clinical studies on immune checkpoint inhibitors for pancreatic cancer are not yet completed and are still recruiting patients. Among the completed trials, there have been findings of a preliminary nature such as delayed disease progression and enhanced overall survival after treatment with immune checkpoint inhibitors in mono- or combination therapy. However, due to small sample sizes, major results are not yet identifiable. The present article provides a clinical overview of immune checkpoint inhibition in pancreatic... (More)

Novel treatment modalities are necessary for pancreatic cancer. Immunotherapy with immune checkpoint inhibition has shown effect in other solid tumors, and could have a place in pancreatic cancer treatment. Most available clinical studies on immune checkpoint inhibitors for pancreatic cancer are not yet completed and are still recruiting patients. Among the completed trials, there have been findings of a preliminary nature such as delayed disease progression and enhanced overall survival after treatment with immune checkpoint inhibitors in mono- or combination therapy. However, due to small sample sizes, major results are not yet identifiable. The present article provides a clinical overview of immune checkpoint inhibition in pancreatic cancer. PubMed, ClinicalTrials.gov and American Society of Clinical Oncology's meeting abstracts were systematically searched for relevant clinical studies. Four articles, five abstracts and 25 clinical trials were identified and analyzed in detail.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Clinical trials, Immune checkpoint inhibitors, Pancreatic cancer
in
World Journal of Gastroenterology
volume
22
issue
43
pages
20 pages
publisher
WJG Press
external identifiers
  • scopus:84995904505
  • wos:000389203400002
ISSN
1007-9327
DOI
10.3748/wjg.v22.i43.9457
language
English
LU publication?
yes
id
481b8184-835c-4182-8bfb-6a91b11aa92a
date added to LUP
2016-12-02 14:14:17
date last changed
2017-10-29 04:54:50
@article{481b8184-835c-4182-8bfb-6a91b11aa92a,
  abstract     = {<p>Novel treatment modalities are necessary for pancreatic cancer. Immunotherapy with immune checkpoint inhibition has shown effect in other solid tumors, and could have a place in pancreatic cancer treatment. Most available clinical studies on immune checkpoint inhibitors for pancreatic cancer are not yet completed and are still recruiting patients. Among the completed trials, there have been findings of a preliminary nature such as delayed disease progression and enhanced overall survival after treatment with immune checkpoint inhibitors in mono- or combination therapy. However, due to small sample sizes, major results are not yet identifiable. The present article provides a clinical overview of immune checkpoint inhibition in pancreatic cancer. PubMed, ClinicalTrials.gov and American Society of Clinical Oncology's meeting abstracts were systematically searched for relevant clinical studies. Four articles, five abstracts and 25 clinical trials were identified and analyzed in detail.</p>},
  author       = {Johansson, Henrik and Andersson, Roland and Bauden, Monika and Hammes, Sarah and Holdenrieder, Stefan and Ansari, Daniel},
  issn         = {1007-9327},
  keyword      = {Clinical trials,Immune checkpoint inhibitors,Pancreatic cancer},
  language     = {eng},
  month        = {11},
  number       = {43},
  pages        = {9457--9476},
  publisher    = {WJG Press},
  series       = {World Journal of Gastroenterology},
  title        = {Immune checkpoint therapy for pancreatic cancer},
  url          = {http://dx.doi.org/10.3748/wjg.v22.i43.9457},
  volume       = {22},
  year         = {2016},
}