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High Plasma Levels of Heparin-Binding Epidermal Growth Factor Are Associated With a More Stable Plaque Phenotype and Reduced Incidence of Coronary Events.

Rattik, Sara LU ; Wigren, Maria LU ; Björkbacka, Harry LU ; Nordin Fredrikson, Gunilla LU ; Hedblad, Bo LU ; Siegbahn, Agneta; Bengtsson, Eva LU ; Schiopu, Alexandru LU ; Edsfeldt, Andreas LU and Dunér, Pontus LU , et al. (2015) In Arteriosclerosis, Thrombosis and Vascular Biology 35(1). p.222-228
Abstract
Rupture of atherosclerotic plaques is the major cause of acute coronary events (CEs). Plaque destabilization is the consequence of an imbalance between inflammatory-driven degradation of fibrous tissue and smooth muscle cell-dependent tissue repair. Proinflammatory factors have been documented extensively as biomarkers of cardiovascular risk but factors that contribute to stabilization of atherosclerotic plaques have received less attention. The present study aimed to investigate whether plasma levels of the smooth muscle cell growth factor epidermal growth factor (EGF), heparin-binding-EGF (HB-EGF), and platelet-derived growth factor correlate with plaque phenotype and incidence of CEs.
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type
Contribution to journal
publication status
published
subject
in
Arteriosclerosis, Thrombosis and Vascular Biology
volume
35
issue
1
pages
222 - 228
publisher
American Heart Association
external identifiers
  • pmid:25359857
  • wos:000346561100031
  • scopus:84920272657
ISSN
1524-4636
DOI
10.1161/ATVBAHA.114.304369
language
English
LU publication?
yes
id
291b8234-2286-4797-b8e3-a5d252fdb535 (old id 4820475)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25359857?dopt=Abstract
date added to LUP
2014-12-01 18:20:15
date last changed
2017-07-02 03:22:17
@article{291b8234-2286-4797-b8e3-a5d252fdb535,
  abstract     = {Rupture of atherosclerotic plaques is the major cause of acute coronary events (CEs). Plaque destabilization is the consequence of an imbalance between inflammatory-driven degradation of fibrous tissue and smooth muscle cell-dependent tissue repair. Proinflammatory factors have been documented extensively as biomarkers of cardiovascular risk but factors that contribute to stabilization of atherosclerotic plaques have received less attention. The present study aimed to investigate whether plasma levels of the smooth muscle cell growth factor epidermal growth factor (EGF), heparin-binding-EGF (HB-EGF), and platelet-derived growth factor correlate with plaque phenotype and incidence of CEs.},
  author       = {Rattik, Sara and Wigren, Maria and Björkbacka, Harry and Nordin Fredrikson, Gunilla and Hedblad, Bo and Siegbahn, Agneta and Bengtsson, Eva and Schiopu, Alexandru and Edsfeldt, Andreas and Dunér, Pontus and Grufman, Helena and Goncalves, Isabel and Nilsson, Jan},
  issn         = {1524-4636},
  language     = {eng},
  number       = {1},
  pages        = {222--228},
  publisher    = {American Heart Association},
  series       = {Arteriosclerosis, Thrombosis and Vascular Biology},
  title        = {High Plasma Levels of Heparin-Binding Epidermal Growth Factor Are Associated With a More Stable Plaque Phenotype and Reduced Incidence of Coronary Events.},
  url          = {http://dx.doi.org/10.1161/ATVBAHA.114.304369},
  volume       = {35},
  year         = {2015},
}