High Plasma Levels of Heparin-Binding Epidermal Growth Factor Are Associated With a More Stable Plaque Phenotype and Reduced Incidence of Coronary Events.
Rattik, Sara LU ; Wigren, Maria LU ; Björkbacka, Harry LU
; Nordin Fredrikson, Gunilla
LU
; Hedblad, Bo
LU
; Siegbahn, Agneta
; Bengtsson, Eva
LU
; Schiopu, Alexandru
LU
; Edsfeldt, Andreas
LU
and Dunér, Pontus
LU
, et al.
(2015)
In Arteriosclerosis, Thrombosis and Vascular Biology
35(1).
p.222-228
- Abstract
- Rupture of atherosclerotic plaques is the major cause of acute coronary events (CEs). Plaque destabilization is the consequence of an imbalance between inflammatory-driven degradation of fibrous tissue and smooth muscle cell-dependent tissue repair. Proinflammatory factors have been documented extensively as biomarkers of cardiovascular risk but factors that contribute to stabilization of atherosclerotic plaques have received less attention. The present study aimed to investigate whether plasma levels of the smooth muscle cell growth factor epidermal growth factor (EGF), heparin-binding-EGF (HB-EGF), and platelet-derived growth factor correlate with plaque phenotype and incidence of CEs.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4820475
- author
- Rattik, Sara
LU
; Wigren, Maria
LU
; Björkbacka, Harry
LU
; Nordin Fredrikson, Gunilla
LU
; Hedblad, Bo
LU
; Siegbahn, Agneta
; Bengtsson, Eva
LU
; Schiopu, Alexandru
LU
; Edsfeldt, Andreas
LU
and Dunér, Pontus
LU
, et al. (More)
- Rattik, Sara
LU
; Wigren, Maria
LU
; Björkbacka, Harry
LU
; Nordin Fredrikson, Gunilla
LU
; Hedblad, Bo
LU
; Siegbahn, Agneta
; Bengtsson, Eva
LU
; Schiopu, Alexandru
LU
; Edsfeldt, Andreas
LU
; Dunér, Pontus
LU
; Grufman, Helena
LU
; Goncalves, Isabel
LU
and Nilsson, Jan
LU
(Less)
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Arteriosclerosis, Thrombosis and Vascular Biology
- volume
- 35
- issue
- 1
- pages
- 222 - 228
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:25359857
- wos:000346561100031
- scopus:84920272657
- pmid:25359857
- ISSN
- 1524-4636
- DOI
- 10.1161/ATVBAHA.114.304369
- language
- English
- LU publication?
- yes
- id
- 291b8234-2286-4797-b8e3-a5d252fdb535 (old id 4820475)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25359857?dopt=Abstract
- date added to LUP
- 2016-04-01 10:59:30
- date last changed
- 2024-10-07 18:32:00
@article{291b8234-2286-4797-b8e3-a5d252fdb535,
abstract = {{Rupture of atherosclerotic plaques is the major cause of acute coronary events (CEs). Plaque destabilization is the consequence of an imbalance between inflammatory-driven degradation of fibrous tissue and smooth muscle cell-dependent tissue repair. Proinflammatory factors have been documented extensively as biomarkers of cardiovascular risk but factors that contribute to stabilization of atherosclerotic plaques have received less attention. The present study aimed to investigate whether plasma levels of the smooth muscle cell growth factor epidermal growth factor (EGF), heparin-binding-EGF (HB-EGF), and platelet-derived growth factor correlate with plaque phenotype and incidence of CEs.}},
author = {{Rattik, Sara and Wigren, Maria and Björkbacka, Harry and Nordin Fredrikson, Gunilla and Hedblad, Bo and Siegbahn, Agneta and Bengtsson, Eva and Schiopu, Alexandru and Edsfeldt, Andreas and Dunér, Pontus and Grufman, Helena and Goncalves, Isabel and Nilsson, Jan}},
issn = {{1524-4636}},
language = {{eng}},
number = {{1}},
pages = {{222--228}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Arteriosclerosis, Thrombosis and Vascular Biology}},
title = {{High Plasma Levels of Heparin-Binding Epidermal Growth Factor Are Associated With a More Stable Plaque Phenotype and Reduced Incidence of Coronary Events.}},
url = {{http://dx.doi.org/10.1161/ATVBAHA.114.304369}},
doi = {{10.1161/ATVBAHA.114.304369}},
volume = {{35}},
year = {{2015}},
}