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Effects of temperature in the estimation of inhomogeneous magnetic transfer (ihMT) in post-mortem human brain

Fritz, Francisco J ; Helms, Gunther LU orcid ; Vaculčiaková, Lenka ; Weiskopf, Nikolaus and Mohammadi, Siawoosh (2022) Joint Annual Meeting ISMRM-ESMRMB 2022 30.
Abstract
Inhomogeneous magnetic transfer (ihMT) is more sensitive to myelin macromolecules than standard MT proxies. Measuring ihMT in the multi-parameter mapping protocol allows calculating ihMT from MT saturation (MTsat) maps and thus inherently correct for the undesired dependencies on flip angle and the longitudinal relaxation rate. Further validation of this new ihMT metric requires measurement of MPM-based ihMT of human post-mortem material. Here, we showed that ihMT of a whole human post-mortem brain is feasible but can lead to
temperature increase in the specimen, which is particularly pronounced in white matter.
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Proceedings of the 2022 ISMRM & ISMRT Annual Meeting and Exhibition
volume
30
article number
2712
publisher
International Society for Magnetic Resonance in Medicine
conference name
Joint Annual Meeting ISMRM-ESMRMB 2022
conference location
London, United Kingdom
conference dates
2022-05-07 - 2022-05-12
language
English
LU publication?
yes
id
482af809-844e-4c85-82ee-a892a1bbcd7f
alternative location
https://index.mirasmart.com/ISMRM2022/PDFfiles/2712.html
date added to LUP
2022-02-07 14:46:57
date last changed
2022-11-29 08:06:04
@inproceedings{482af809-844e-4c85-82ee-a892a1bbcd7f,
  abstract     = {{Inhomogeneous magnetic transfer (ihMT) is more sensitive to myelin macromolecules than standard MT proxies. Measuring ihMT in the multi-parameter mapping protocol allows calculating ihMT from MT saturation (MTsat) maps and thus inherently correct for the undesired dependencies on flip angle and the longitudinal relaxation rate. Further validation of this new ihMT metric requires measurement of MPM-based ihMT of human post-mortem material. Here, we showed that ihMT of a whole human post-mortem brain is feasible but can lead to<br/>temperature increase in the specimen, which is particularly pronounced in white matter.<br/>}},
  author       = {{Fritz, Francisco J and Helms, Gunther and Vaculčiaková, Lenka and Weiskopf, Nikolaus and Mohammadi, Siawoosh}},
  booktitle    = {{Proceedings of the 2022 ISMRM & ISMRT Annual Meeting and Exhibition}},
  language     = {{eng}},
  month        = {{04}},
  publisher    = {{International Society for Magnetic Resonance in Medicine}},
  title        = {{Effects of temperature in the estimation of inhomogeneous magnetic transfer (ihMT) in post-mortem human brain}},
  url          = {{https://index.mirasmart.com/ISMRM2022/PDFfiles/2712.html}},
  volume       = {{30}},
  year         = {{2022}},
}