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Assessment of perfusion in normal carpal bones with dynamic gadolinium-enhanced MRI at 3 tesla.

Müller, Gunilla LU ; Månsson, Sven LU ; Müller, Markus LU ; Ekberg, Olle LU and Björkman, Anders LU (2013) In Journal of Magnetic Resonance Imaging 38(1). p.168-172
Abstract
PURPOSE: To investigate the normal enhancement patterns of the scaphoid, lunate, and capitate bones with dynamic contrast-enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: The study was approved by the hospital's Ethics Committee. Nineteen volunteers (13 female, 6 male; mean age 38 years) were examined and all gave written consent. Perfusion was assessed at 3 Tesla using dynamic contrast-enhanced MRI. After two-dimensional (2D) motion correction of the data set, regions of interest were placed in the capitate, lunate, and distal and proximal pole of scaphoid bone and from the mean signal intensities (SI), the enhancement was computed. The four locations were compared for time to peak, delay time, maximum enhancement, and... (More)
PURPOSE: To investigate the normal enhancement patterns of the scaphoid, lunate, and capitate bones with dynamic contrast-enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: The study was approved by the hospital's Ethics Committee. Nineteen volunteers (13 female, 6 male; mean age 38 years) were examined and all gave written consent. Perfusion was assessed at 3 Tesla using dynamic contrast-enhanced MRI. After two-dimensional (2D) motion correction of the data set, regions of interest were placed in the capitate, lunate, and distal and proximal pole of scaphoid bone and from the mean signal intensities (SI), the enhancement was computed. The four locations were compared for time to peak, delay time, maximum enhancement, and maximum slope using Friedman's two-way analysis of variance. RESULTS: Typical SI versus time curves revealed two components: a faster component with strong contrast enhancement and a slow component with prolonged enhancement. The mean value (standard deviation, SD) for maximum enhancement was 51 (33)% in the capitate, 54 (25)% in the lunate, 51 (34)% in the proximal pole and 51 (28)% in the distal pole of the scaphoid. The result of the Friedman test showed no significant difference (P < 0.05) in the perfusion variables between the capitate, lunate, and distal and proximal scaphoid bones. CONCLUSION: Assessment of perfusion in normal carpal bone using contrast-enhanced MRI is possible. Optimization of the method and understanding of the normal perfusion may allow evaluation of pathological conditions such as osteonecrosis. J. Magn. Reson. Imaging 2013;. © 2013 Wiley Periodicals, Inc. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Journal of Magnetic Resonance Imaging
volume
38
issue
1
pages
168 - 172
publisher
John Wiley & Sons
external identifiers
  • wos:000321614600020
  • pmid:23188589
  • scopus:84880095270
ISSN
1522-2586
DOI
10.1002/jmri.23951
language
English
LU publication?
yes
id
482be63c-4f9f-42dd-b03e-c68709e40761 (old id 3218426)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23188589?dopt=Abstract
date added to LUP
2012-12-13 14:13:19
date last changed
2019-03-12 01:19:35
@article{482be63c-4f9f-42dd-b03e-c68709e40761,
  abstract     = {PURPOSE: To investigate the normal enhancement patterns of the scaphoid, lunate, and capitate bones with dynamic contrast-enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: The study was approved by the hospital's Ethics Committee. Nineteen volunteers (13 female, 6 male; mean age 38 years) were examined and all gave written consent. Perfusion was assessed at 3 Tesla using dynamic contrast-enhanced MRI. After two-dimensional (2D) motion correction of the data set, regions of interest were placed in the capitate, lunate, and distal and proximal pole of scaphoid bone and from the mean signal intensities (SI), the enhancement was computed. The four locations were compared for time to peak, delay time, maximum enhancement, and maximum slope using Friedman's two-way analysis of variance. RESULTS: Typical SI versus time curves revealed two components: a faster component with strong contrast enhancement and a slow component with prolonged enhancement. The mean value (standard deviation, SD) for maximum enhancement was 51 (33)% in the capitate, 54 (25)% in the lunate, 51 (34)% in the proximal pole and 51 (28)% in the distal pole of the scaphoid. The result of the Friedman test showed no significant difference (P &lt; 0.05) in the perfusion variables between the capitate, lunate, and distal and proximal scaphoid bones. CONCLUSION: Assessment of perfusion in normal carpal bone using contrast-enhanced MRI is possible. Optimization of the method and understanding of the normal perfusion may allow evaluation of pathological conditions such as osteonecrosis. J. Magn. Reson. Imaging 2013;. © 2013 Wiley Periodicals, Inc.},
  author       = {Müller, Gunilla and Månsson, Sven and Müller, Markus and Ekberg, Olle and Björkman, Anders},
  issn         = {1522-2586},
  language     = {eng},
  number       = {1},
  pages        = {168--172},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Magnetic Resonance Imaging},
  title        = {Assessment of perfusion in normal carpal bones with dynamic gadolinium-enhanced MRI at 3 tesla.},
  url          = {http://dx.doi.org/10.1002/jmri.23951},
  volume       = {38},
  year         = {2013},
}