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Systemic Lupus Erythematosus Prevalence in Sweden in 2010: What Do National Registers Say?

Simard, Julia F.; Sjowall, Christopher; Ronnblom, Lars; Jönsen, Andreas LU and Svenungsson, Elisabet (2014) In Arthritis Care and Research1988-01-01+01:002000-01-01+01:00 66(11). p.1710-1717
Abstract
Objective. Worldwide prevalence estimates of systemic lupus erythematosus (SLE) range from 3 to 207 per 100,000, depending on region and population, SLE definition, case sources, and other methodologic considerations. We aimed to determine the prevalence of SLE in Sweden on January 1, 2010, using population-based registers. Methods. Linking multiple national registers, we identified all possible inpatient and outpatient visits with SLE-specific discharge diagnoses and relevant prescription dispensations among living individuals registered in Sweden on January 1, 2010. SLE was defined from a lenient classification (requiring only a single visit) to stricter definitions that required multiple visits with a history of relevant specialist care... (More)
Objective. Worldwide prevalence estimates of systemic lupus erythematosus (SLE) range from 3 to 207 per 100,000, depending on region and population, SLE definition, case sources, and other methodologic considerations. We aimed to determine the prevalence of SLE in Sweden on January 1, 2010, using population-based registers. Methods. Linking multiple national registers, we identified all possible inpatient and outpatient visits with SLE-specific discharge diagnoses and relevant prescription dispensations among living individuals registered in Sweden on January 1, 2010. SLE was defined from a lenient classification (requiring only a single visit) to stricter definitions that required multiple visits with a history of relevant specialist care and a dispensation for common SLE medications. Prevalence was calculated overall and by sex, age (0-14 years, 15-49 years, and >= 50 years, as well as in 5-year age groups), and county of residence. Results. Overall prevalence ranged from 46 per 100,000 for the strictest definition to 85 per 100,000 for the least strict definition. As expected, SLE was more common among females (range 79-144 per 100,000) than males (range 12-25 per 100,000) and varied by age. The up to 4-fold variation by county was unexpected. Prevalence generally increased with age (2, 52, and 95 per 100,000 by increasing age group, 0-14 years, 15-49 years, and >= 50 years, respectively, using a moderately strict definition) and also varied by county. Conclusion. Variations of prevalence by age and sex were consistent with previous studies and overall ranged from 46 to 85 per 100,000. We observed a surprising geographic variation in the prevalence of SLE in Sweden on January 1, 2010, according to multiple definitions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Arthritis Care and Research1988-01-01+01:002000-01-01+01:00
volume
66
issue
11
pages
1710 - 1717
publisher
John Wiley & Sons
external identifiers
  • wos:000344334200015
  • scopus:84922065487
ISSN
2151-4658
DOI
10.1002/acr.22355
language
English
LU publication?
yes
id
abb95ccb-38f8-4bc1-909c-cad28a2269cf (old id 4875032)
date added to LUP
2015-01-07 10:23:50
date last changed
2016-10-13 00:19:14
@article{abb95ccb-38f8-4bc1-909c-cad28a2269cf,
  abstract     = {Objective. Worldwide prevalence estimates of systemic lupus erythematosus (SLE) range from 3 to 207 per 100,000, depending on region and population, SLE definition, case sources, and other methodologic considerations. We aimed to determine the prevalence of SLE in Sweden on January 1, 2010, using population-based registers. Methods. Linking multiple national registers, we identified all possible inpatient and outpatient visits with SLE-specific discharge diagnoses and relevant prescription dispensations among living individuals registered in Sweden on January 1, 2010. SLE was defined from a lenient classification (requiring only a single visit) to stricter definitions that required multiple visits with a history of relevant specialist care and a dispensation for common SLE medications. Prevalence was calculated overall and by sex, age (0-14 years, 15-49 years, and >= 50 years, as well as in 5-year age groups), and county of residence. Results. Overall prevalence ranged from 46 per 100,000 for the strictest definition to 85 per 100,000 for the least strict definition. As expected, SLE was more common among females (range 79-144 per 100,000) than males (range 12-25 per 100,000) and varied by age. The up to 4-fold variation by county was unexpected. Prevalence generally increased with age (2, 52, and 95 per 100,000 by increasing age group, 0-14 years, 15-49 years, and >= 50 years, respectively, using a moderately strict definition) and also varied by county. Conclusion. Variations of prevalence by age and sex were consistent with previous studies and overall ranged from 46 to 85 per 100,000. We observed a surprising geographic variation in the prevalence of SLE in Sweden on January 1, 2010, according to multiple definitions.},
  author       = {Simard, Julia F. and Sjowall, Christopher and Ronnblom, Lars and Jönsen, Andreas and Svenungsson, Elisabet},
  issn         = {2151-4658},
  language     = {eng},
  number       = {11},
  pages        = {1710--1717},
  publisher    = {John Wiley & Sons},
  series       = {Arthritis Care and Research1988-01-01+01:002000-01-01+01:00},
  title        = {Systemic Lupus Erythematosus Prevalence in Sweden in 2010: What Do National Registers Say?},
  url          = {http://dx.doi.org/10.1002/acr.22355},
  volume       = {66},
  year         = {2014},
}