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Increased carotid plaque burden in men with the fibrillin-1 2/3 genotype

De Basso, Rachel; Hedblad, Bo LU ; Carlson, Joyce LU ; Persson, Margaretha LU ; Östling, Gerd LU and Lanne, Toste (2014) In Clinical and Experimental Pharmacology and Physiology 41(9). p.637-642
Abstract
Fibrillin-1 (FBN1) is an important constituent of the vascular wall and earlier studies have indicated an effect of the FBN1 2/3 genotype on blood pressure as well as aortic stiffness in men. The aim of the present study was to determine whether the FBN1 2/3 genotype was associated with the presence of carotid plaque and incident cardiovascular morbidity and mortality in middle-aged subjects. The FBN1 genotype was characterized in 5765 subjects (2424 men, 3341 women; age 45-69years) recruited from the Malmo Diet and Cancer Study Cardiovascular Cohort, Sweden. Plaque occurrence and intima-media thickness (IMT) of the carotid artery were assessed by ultrasound. The incidence of first cardiovascular events (myocardial infarction and stroke)... (More)
Fibrillin-1 (FBN1) is an important constituent of the vascular wall and earlier studies have indicated an effect of the FBN1 2/3 genotype on blood pressure as well as aortic stiffness in men. The aim of the present study was to determine whether the FBN1 2/3 genotype was associated with the presence of carotid plaque and incident cardiovascular morbidity and mortality in middle-aged subjects. The FBN1 genotype was characterized in 5765 subjects (2424 men, 3341 women; age 45-69years) recruited from the Malmo Diet and Cancer Study Cardiovascular Cohort, Sweden. Plaque occurrence and intima-media thickness (IMT) of the carotid artery were assessed by ultrasound. The incidence of first cardiovascular events (myocardial infarction and stroke) and cause-specific mortality were monitored over a mean follow-up period of 13.2years. The most common FBN1 genotypes were 2/2, 2/3 and 2/4, which accounted for 92.2% (n=5317) of subjects. There were no differences between the three genotypes regarding age, blood pressure, glucose, lipids, smoking habits, common carotid artery diameter and intima-media thickness in men and women. The presence of plaque in the carotid artery was higher in men with the 2/3 genotype compared with the 2/2 and 2/4 genotypes (55% vs 46% and 50%, respectively; P=0.007). No similar differences were observed in women. No significant relationship was observed between FBN1 genotypes and the incidence of cardiovascular disease or all-cause mortality. The increased prevalence of plaque in the carotid artery of middle-aged men with the FBN1 2/3 genotype indicates pathological arterial wall remodelling with a more pronounced atherosclerotic burden. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
arterial wall, blood pressure, cardiovascular risk, human, intima-media, thickness
in
Clinical and Experimental Pharmacology and Physiology
volume
41
issue
9
pages
637 - 642
publisher
Wiley-Blackwell
external identifiers
  • wos:000344348100004
  • scopus:84911147884
ISSN
1440-1681
DOI
10.1111/1440-1681.12259
language
English
LU publication?
yes
id
c98cd643-8548-47b3-affd-72cda9fe48ff (old id 4875851)
date added to LUP
2015-01-07 10:28:55
date last changed
2017-01-01 03:12:02
@article{c98cd643-8548-47b3-affd-72cda9fe48ff,
  abstract     = {Fibrillin-1 (FBN1) is an important constituent of the vascular wall and earlier studies have indicated an effect of the FBN1 2/3 genotype on blood pressure as well as aortic stiffness in men. The aim of the present study was to determine whether the FBN1 2/3 genotype was associated with the presence of carotid plaque and incident cardiovascular morbidity and mortality in middle-aged subjects. The FBN1 genotype was characterized in 5765 subjects (2424 men, 3341 women; age 45-69years) recruited from the Malmo Diet and Cancer Study Cardiovascular Cohort, Sweden. Plaque occurrence and intima-media thickness (IMT) of the carotid artery were assessed by ultrasound. The incidence of first cardiovascular events (myocardial infarction and stroke) and cause-specific mortality were monitored over a mean follow-up period of 13.2years. The most common FBN1 genotypes were 2/2, 2/3 and 2/4, which accounted for 92.2% (n=5317) of subjects. There were no differences between the three genotypes regarding age, blood pressure, glucose, lipids, smoking habits, common carotid artery diameter and intima-media thickness in men and women. The presence of plaque in the carotid artery was higher in men with the 2/3 genotype compared with the 2/2 and 2/4 genotypes (55% vs 46% and 50%, respectively; P=0.007). No similar differences were observed in women. No significant relationship was observed between FBN1 genotypes and the incidence of cardiovascular disease or all-cause mortality. The increased prevalence of plaque in the carotid artery of middle-aged men with the FBN1 2/3 genotype indicates pathological arterial wall remodelling with a more pronounced atherosclerotic burden.},
  author       = {De Basso, Rachel and Hedblad, Bo and Carlson, Joyce and Persson, Margaretha and Östling, Gerd and Lanne, Toste},
  issn         = {1440-1681},
  keyword      = {arterial wall,blood pressure,cardiovascular risk,human,intima-media,thickness},
  language     = {eng},
  number       = {9},
  pages        = {637--642},
  publisher    = {Wiley-Blackwell},
  series       = {Clinical and Experimental Pharmacology and Physiology},
  title        = {Increased carotid plaque burden in men with the fibrillin-1 2/3 genotype},
  url          = {http://dx.doi.org/10.1111/1440-1681.12259},
  volume       = {41},
  year         = {2014},
}