Optimizing the friability of a tablet formulation
(1987) In Drug Development and Industrial Pharmacy 13(6). p.1063-1067- Abstract
- The impact on tablet friability caused by the loss-on-drying of the granulation, the granule-size distribution, the lubricant concentration, the compression force, and the pre-compression was scrutinized in a factorially designed experiment. A reduction of friability was obtained by reducing the deviation of the granulation loss-on-drying from approximately 4.6%; by decreasing the lubricant concentration; or by increasing the compression force.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4897258
- author
- Lindberg, N.-O. and Holmquist, Björn LU
- organization
- publishing date
- 1987
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Drug Development and Industrial Pharmacy
- volume
- 13
- issue
- 6
- pages
- 1063 - 1067
- publisher
- Marcel Dekker
- external identifiers
-
- scopus:0343073350
- ISSN
- 0363-9045
- DOI
- 10.3109/03639048709068370
- language
- English
- LU publication?
- yes
- id
- 89eb7ce2-9e1c-464e-bef4-26993df6bd26 (old id 4897258)
- date added to LUP
- 2016-04-01 11:53:39
- date last changed
- 2021-01-03 07:00:56
@article{89eb7ce2-9e1c-464e-bef4-26993df6bd26, abstract = {{The impact on tablet friability caused by the loss-on-drying of the granulation, the granule-size distribution, the lubricant concentration, the compression force, and the pre-compression was scrutinized in a factorially designed experiment. A reduction of friability was obtained by reducing the deviation of the granulation loss-on-drying from approximately 4.6%; by decreasing the lubricant concentration; or by increasing the compression force.}}, author = {{Lindberg, N.-O. and Holmquist, Björn}}, issn = {{0363-9045}}, language = {{eng}}, number = {{6}}, pages = {{1063--1067}}, publisher = {{Marcel Dekker}}, series = {{Drug Development and Industrial Pharmacy}}, title = {{Optimizing the friability of a tablet formulation}}, url = {{http://dx.doi.org/10.3109/03639048709068370}}, doi = {{10.3109/03639048709068370}}, volume = {{13}}, year = {{1987}}, }