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Optimizing the friability of a tablet formulation

Lindberg, N.-O. and Holmquist, Björn LU (1987) In Drug Development and Industrial Pharmacy 13(6). p.1063-1067
Abstract
The impact on tablet friability caused by the loss-on-drying of the granulation, the granule-size distribution, the lubricant concentration, the compression force, and the pre-compression was scrutinized in a factorially designed experiment. A reduction of friability was obtained by reducing the deviation of the granulation loss-on-drying from approximately 4.6%; by decreasing the lubricant concentration; or by increasing the compression force.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Drug Development and Industrial Pharmacy
volume
13
issue
6
pages
1063 - 1067
publisher
Marcel Dekker
external identifiers
  • scopus:0343073350
ISSN
0363-9045
DOI
10.3109/03639048709068370
language
English
LU publication?
yes
id
89eb7ce2-9e1c-464e-bef4-26993df6bd26 (old id 4897258)
date added to LUP
2015-01-12 11:05:11
date last changed
2017-01-01 04:38:33
@article{89eb7ce2-9e1c-464e-bef4-26993df6bd26,
  abstract     = {The impact on tablet friability caused by the loss-on-drying of the granulation, the granule-size distribution, the lubricant concentration, the compression force, and the pre-compression was scrutinized in a factorially designed experiment. A reduction of friability was obtained by reducing the deviation of the granulation loss-on-drying from approximately 4.6%; by decreasing the lubricant concentration; or by increasing the compression force.},
  author       = {Lindberg, N.-O. and Holmquist, Björn},
  issn         = {0363-9045},
  language     = {eng},
  number       = {6},
  pages        = {1063--1067},
  publisher    = {Marcel Dekker},
  series       = {Drug Development and Industrial Pharmacy},
  title        = {Optimizing the friability of a tablet formulation},
  url          = {http://dx.doi.org/10.3109/03639048709068370},
  volume       = {13},
  year         = {1987},
}