Structural and Prognostic Clinical Insights in Cardiovascular Imaging
(2025) In Lund University, Faculty of Medicine Doctoral Dissertation Series- Abstract
- In Paper I, 4703 subjects from the Malmö Cost Cancer cohort, with a mean follow-up of 16.5 years, were evaluated for future risk of ischemic stroke in relation to levels of s-LOX1. An increased risk was found for higher level of sLOX-1 OR 1.75 (1.28-2.39), p<0.001, increasing in presence of carotid plaque OR 2.42 (1.71-3.44), p<0.001. Endothelial cells were exposed to oxLDL, resulting in release of sLOX-1. Plaque and plasma content of sLOX-1 was analyzed for 202 patients in the Carotid Imaging Project who underwent carotid endarterectomy. A significant association between plasma sLOX-1 and plaque content of sLOX-1 was found (r=0209, p=0.004). Plaques with higher level of sLOX-1 had more features of inflammation.
In Paper II,... (More) - In Paper I, 4703 subjects from the Malmö Cost Cancer cohort, with a mean follow-up of 16.5 years, were evaluated for future risk of ischemic stroke in relation to levels of s-LOX1. An increased risk was found for higher level of sLOX-1 OR 1.75 (1.28-2.39), p<0.001, increasing in presence of carotid plaque OR 2.42 (1.71-3.44), p<0.001. Endothelial cells were exposed to oxLDL, resulting in release of sLOX-1. Plaque and plasma content of sLOX-1 was analyzed for 202 patients in the Carotid Imaging Project who underwent carotid endarterectomy. A significant association between plasma sLOX-1 and plaque content of sLOX-1 was found (r=0209, p=0.004). Plaques with higher level of sLOX-1 had more features of inflammation.
In Paper II, cardiac veins of 99 heart failure patients were mapped using cardiac computed tomography angiography (CCTA) and transferred to a 17-segment model of the left ventricle myocardium. No differences
in number or distribution of cardiac veins for any patient or technical factors was found.
In Paper III, obesity was related to presence of coronary and carotid artery disease, in the absence or presence of metabolic syndrome (MetS) criteria for 23,674 participants in the Swedish CArdioPumonary bioImaging Study (SCPAIS). For obese without MetS, severity of coronary stenosis was increased OR 1.47 (1.34-1.62, p<0.0001) compared to normal weight without MetS. When evaluating individual criteria for MetS regarding increased atherosclerosis, high blood pressure was most important.
In Paper IV, presence and characteristics of coronary myocardial bridging (MB), detected by CCTA, for 434 chest-pain patients was compared to 196 non-chest pain subjects from SCAPIS. MB was common for both groups. Chest pain patients did not have more MB. For non-chest pain subjects, number of premature ventricular contractions was higher for subjects with MB in proximal LAD. Subjects with ventricular arrhythmia had more often MB in proximal LAD than subjects without ventricular arrhythmia.
The thesis advances the understanding of the development and progression of cardiovascular disease in prediction, inflammation in circulation and in plaques, mapping of anatomical and other features of vessels in pre-procedural settings and in relation to symptoms, to severity of atherosclerosis in the setting of obesity, using cardiovascular imaging. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/48995aff-ccc2-439e-b594-651ed59bcc28
- author
- Markstad, Hanna LU
- supervisor
- opponent
-
- Associate Professor Lidén, Mats, Faculty of Medicine and Health, Örebro University, Sweden
- organization
- publishing date
- 2025
- type
- Thesis
- publication status
- published
- subject
- keywords
- Cardiovascular Imaging, Cardiac Computed Tomography Angiograpy, Cardiac CT, Risk-factors, Myocardial Bridging, LOX1, s-LOX1
- in
- Lund University, Faculty of Medicine Doctoral Dissertation Series
- issue
- 2025:102
- pages
- 107 pages
- publisher
- Lund University, Faculty of Medicine
- defense location
- Segerfalksalen, BMC A10, Sölvegatan 17 i Lund
- defense date
- 2025-10-17 09:00:00
- ISSN
- 1652-8220
- ISBN
- 978-91-8021-755-2
- language
- English
- LU publication?
- yes
- id
- 48995aff-ccc2-439e-b594-651ed59bcc28
- date added to LUP
- 2025-09-23 15:11:45
- date last changed
- 2025-09-24 08:17:43
@phdthesis{48995aff-ccc2-439e-b594-651ed59bcc28,
abstract = {{In Paper I, 4703 subjects from the Malmö Cost Cancer cohort, with a mean follow-up of 16.5 years, were evaluated for future risk of ischemic stroke in relation to levels of s-LOX1. An increased risk was found for higher level of sLOX-1 OR 1.75 (1.28-2.39), p<0.001, increasing in presence of carotid plaque OR 2.42 (1.71-3.44), p<0.001. Endothelial cells were exposed to oxLDL, resulting in release of sLOX-1. Plaque and plasma content of sLOX-1 was analyzed for 202 patients in the Carotid Imaging Project who underwent carotid endarterectomy. A significant association between plasma sLOX-1 and plaque content of sLOX-1 was found (r=0209, p=0.004). Plaques with higher level of sLOX-1 had more features of inflammation.<br/>In Paper II, cardiac veins of 99 heart failure patients were mapped using cardiac computed tomography angiography (CCTA) and transferred to a 17-segment model of the left ventricle myocardium. No differences<br/>in number or distribution of cardiac veins for any patient or technical factors was found.<br/>In Paper III, obesity was related to presence of coronary and carotid artery disease, in the absence or presence of metabolic syndrome (MetS) criteria for 23,674 participants in the Swedish CArdioPumonary bioImaging Study (SCPAIS). For obese without MetS, severity of coronary stenosis was increased OR 1.47 (1.34-1.62, p<0.0001) compared to normal weight without MetS. When evaluating individual criteria for MetS regarding increased atherosclerosis, high blood pressure was most important.<br/>In Paper IV, presence and characteristics of coronary myocardial bridging (MB), detected by CCTA, for 434 chest-pain patients was compared to 196 non-chest pain subjects from SCAPIS. MB was common for both groups. Chest pain patients did not have more MB. For non-chest pain subjects, number of premature ventricular contractions was higher for subjects with MB in proximal LAD. Subjects with ventricular arrhythmia had more often MB in proximal LAD than subjects without ventricular arrhythmia.<br/>The thesis advances the understanding of the development and progression of cardiovascular disease in prediction, inflammation in circulation and in plaques, mapping of anatomical and other features of vessels in pre-procedural settings and in relation to symptoms, to severity of atherosclerosis in the setting of obesity, using cardiovascular imaging.}},
author = {{Markstad, Hanna}},
isbn = {{978-91-8021-755-2}},
issn = {{1652-8220}},
keywords = {{Cardiovascular Imaging; Cardiac Computed Tomography Angiograpy; Cardiac CT; Risk-factors; Myocardial Bridging; LOX1; s-LOX1}},
language = {{eng}},
number = {{2025:102}},
publisher = {{Lund University, Faculty of Medicine}},
school = {{Lund University}},
series = {{Lund University, Faculty of Medicine Doctoral Dissertation Series}},
title = {{Structural and Prognostic Clinical Insights in Cardiovascular Imaging}},
url = {{https://lup.lub.lu.se/search/files/228364467/Avhandling_Hanna_Markstad_LUCRIS.pdf}},
year = {{2025}},
}