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Theophylline is able to partially revert cachexia in tumour-bearing rats

Olivan, Mireia; Springer, Jochen; Busquets, Sílvia; Tschirner, Anika; Figueras, Maite; Toledo, Miriam; Fontes-Oliveira, Cibely LU ; Genovese, Maria Inés; Ventura da Silva, Paula and Sette, Angelica, et al. (2012) In Nutrition and Metabolism 9(1). p.1-8
Abstract

UNLABELLED:

BACKGROUND AND AIMS: The aim of the present investigation was to examine the anti-wasting effects of theophylline (a methylxantine present in tea leaves) on a rat model of cancer cachexia.

METHODS: The in vitro effects of the nutraceuticals on proteolysis were examined on muscle cell cultures submitted to hyperthermia. Individual muscle weights, muscle gene expression, body composition and cardiac function were measured in rats bearing the Yoshida AH-130 ascites hepatoma, following theophylline treatment.

RESULTS: Theophylline treatment inhibited proteolysis in C2C12 cell line and resulted in an anti-proteolytic effect on muscle tissue (soleus and heart), which was associated with a decrease in circulating... (More)

UNLABELLED:

BACKGROUND AND AIMS: The aim of the present investigation was to examine the anti-wasting effects of theophylline (a methylxantine present in tea leaves) on a rat model of cancer cachexia.

METHODS: The in vitro effects of the nutraceuticals on proteolysis were examined on muscle cell cultures submitted to hyperthermia. Individual muscle weights, muscle gene expression, body composition and cardiac function were measured in rats bearing the Yoshida AH-130 ascites hepatoma, following theophylline treatment.

RESULTS: Theophylline treatment inhibited proteolysis in C2C12 cell line and resulted in an anti-proteolytic effect on muscle tissue (soleus and heart), which was associated with a decrease in circulating TNF-alpha levels and with a decreased proteolytic systems gene expression. Treatment with the nutraceutical also resulted in an improvement in body composition and cardiac function.

CONCLUSION: Theophylline - alone or in combination with drugs - may be a candidate molecule for the treatment of cancer cachexia.

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publishing date
type
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publication status
published
keywords
Journal Article
in
Nutrition and Metabolism
volume
9
issue
1
pages
1 - 8
publisher
BioMed Central
external identifiers
  • scopus:84865074747
ISSN
1743-7075
DOI
10.1186/1743-7075-9-76
language
English
LU publication?
no
id
48a1ef8e-9824-4286-a38c-99ce5fedc042
date added to LUP
2017-02-28 16:12:03
date last changed
2017-11-05 05:14:37
@article{48a1ef8e-9824-4286-a38c-99ce5fedc042,
  abstract     = {<p>UNLABELLED: </p><p>BACKGROUND AND AIMS: The aim of the present investigation was to examine the anti-wasting effects of theophylline (a methylxantine present in tea leaves) on a rat model of cancer cachexia.</p><p>METHODS: The in vitro effects of the nutraceuticals on proteolysis were examined on muscle cell cultures submitted to hyperthermia. Individual muscle weights, muscle gene expression, body composition and cardiac function were measured in rats bearing the Yoshida AH-130 ascites hepatoma, following theophylline treatment.</p><p>RESULTS: Theophylline treatment inhibited proteolysis in C2C12 cell line and resulted in an anti-proteolytic effect on muscle tissue (soleus and heart), which was associated with a decrease in circulating TNF-alpha levels and with a decreased proteolytic systems gene expression. Treatment with the nutraceutical also resulted in an improvement in body composition and cardiac function.</p><p>CONCLUSION: Theophylline - alone or in combination with drugs - may be a candidate molecule for the treatment of cancer cachexia.</p>},
  articleno    = {76},
  author       = {Olivan, Mireia and Springer, Jochen and Busquets, Sílvia and Tschirner, Anika and Figueras, Maite and Toledo, Miriam and Fontes-Oliveira, Cibely and Genovese, Maria Inés and Ventura da Silva, Paula and Sette, Angelica and López-Soriano, Francisco J and Anker, Stefan D. and Argilés, Josep M},
  issn         = {1743-7075},
  keyword      = {Journal Article},
  language     = {eng},
  month        = {08},
  number       = {1},
  pages        = {1--8},
  publisher    = {BioMed Central},
  series       = {Nutrition and Metabolism},
  title        = {Theophylline is able to partially revert cachexia in tumour-bearing rats},
  url          = {http://dx.doi.org/10.1186/1743-7075-9-76},
  volume       = {9},
  year         = {2012},
}