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A National Swedish Longitudinal Twin-Sibling Study of alcohol use disorders among males

Long, Elizabeth C.; Lönn, Sara L. LU ; Sundquist, Jan LU ; Sundquist, Kristina LU and Kendler, Kenneth S. LU (2017) In Addiction 112(8). p.1378-1385
Abstract

Aims: To examine whether genetic influences on the development of alcohol use disorders (AUD) among men during emerging adulthood through mid-adulthood are stable or dynamic. Design: A twin study modeling developmental changes in the genetic and environmental influences on AUD during three age periods (18-25, 26-33 and 33-41) as a Cholesky decomposition. Setting: Sweden. Participants: Swedish male twin pairs (1532 monozygotic and 1940 dizygotic) and 66033 full male sibling pairs born less than 2 years apart. Measurements: AUD was identified based on Swedish medical and legal registries. Findings: The best-fitting model included additive genetic and unique environmental factors, with no evidence for shared environmental factors. Although... (More)

Aims: To examine whether genetic influences on the development of alcohol use disorders (AUD) among men during emerging adulthood through mid-adulthood are stable or dynamic. Design: A twin study modeling developmental changes in the genetic and environmental influences on AUD during three age periods (18-25, 26-33 and 33-41) as a Cholesky decomposition. Setting: Sweden. Participants: Swedish male twin pairs (1532 monozygotic and 1940 dizygotic) and 66033 full male sibling pairs born less than 2 years apart. Measurements: AUD was identified based on Swedish medical and legal registries. Findings: The best-fitting model included additive genetic and unique environmental factors, with no evidence for shared environmental factors. Although the total heritability was stable over time, there were two major genetic factors contributing to AUD risk, one beginning at ages 18-25 with a modest decline in importance over time [0.84; confidence interval (CI) = 0.83-0.88], and another of less impact beginning at ages 26-33 with a modest increase in importance by ages 33-41 (0.31; CI = 0.05-0.47). Conclusions: The heritability of alcohol use disorders among Swedish men appears to be stable among three age periods: 18-25 years, 26-33 years, and 33-41 years. Two sets of genetic risk factors contribute to alcohol use disorders risk, with one originating during the ages 18-25 years and another coming online at 26-33 years, providing support for the developmentally dynamic hypothesis.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alcohol use disorders, Developmentally dynamic hypothesis, General population, Genetic influences, Longitudinal modeling, Twin modeling
in
Addiction
volume
112
issue
8
pages
1378 - 1385
publisher
Wiley-Blackwell
external identifiers
  • scopus:85018989942
  • wos:000405246200012
ISSN
0965-2140
DOI
10.1111/add.13833
language
English
LU publication?
yes
id
48c34ca9-19d6-4ef5-9c52-9a1985c6acdb
date added to LUP
2017-06-01 12:52:57
date last changed
2018-01-07 12:05:56
@article{48c34ca9-19d6-4ef5-9c52-9a1985c6acdb,
  abstract     = {<p>Aims: To examine whether genetic influences on the development of alcohol use disorders (AUD) among men during emerging adulthood through mid-adulthood are stable or dynamic. Design: A twin study modeling developmental changes in the genetic and environmental influences on AUD during three age periods (18-25, 26-33 and 33-41) as a Cholesky decomposition. Setting: Sweden. Participants: Swedish male twin pairs (1532 monozygotic and 1940 dizygotic) and 66033 full male sibling pairs born less than 2 years apart. Measurements: AUD was identified based on Swedish medical and legal registries. Findings: The best-fitting model included additive genetic and unique environmental factors, with no evidence for shared environmental factors. Although the total heritability was stable over time, there were two major genetic factors contributing to AUD risk, one beginning at ages 18-25 with a modest decline in importance over time [0.84; confidence interval (CI) = 0.83-0.88], and another of less impact beginning at ages 26-33 with a modest increase in importance by ages 33-41 (0.31; CI = 0.05-0.47). Conclusions: The heritability of alcohol use disorders among Swedish men appears to be stable among three age periods: 18-25 years, 26-33 years, and 33-41 years. Two sets of genetic risk factors contribute to alcohol use disorders risk, with one originating during the ages 18-25 years and another coming online at 26-33 years, providing support for the developmentally dynamic hypothesis.</p>},
  author       = {Long, Elizabeth C. and Lönn, Sara L. and Sundquist, Jan and Sundquist, Kristina and Kendler, Kenneth S.},
  issn         = {0965-2140},
  keyword      = {Alcohol use disorders,Developmentally dynamic hypothesis,General population,Genetic influences,Longitudinal modeling,Twin modeling},
  language     = {eng},
  month        = {05},
  number       = {8},
  pages        = {1378--1385},
  publisher    = {Wiley-Blackwell},
  series       = {Addiction},
  title        = {A National Swedish Longitudinal Twin-Sibling Study of alcohol use disorders among males},
  url          = {http://dx.doi.org/10.1111/add.13833},
  volume       = {112},
  year         = {2017},
}