Target protection as a key antibiotic resistance mechanism
(2020) In Nature Reviews Microbiology 18(11). p.637-648- Abstract
Antibiotic resistance is mediated through several distinct mechanisms, most of which are relatively well understood and the clinical importance of which has long been recognized. Until very recently, neither of these statements was readily applicable to the class of resistance mechanism known as target protection, a phenomenon whereby a resistance protein physically associates with an antibiotic target to rescue it from antibiotic-mediated inhibition. In this Review, we summarize recent progress in understanding the nature and importance of target protection. In particular, we describe the molecular basis of the known target protection systems, emphasizing that target protection does not involve a single, uniform mechanism but is... (More)
Antibiotic resistance is mediated through several distinct mechanisms, most of which are relatively well understood and the clinical importance of which has long been recognized. Until very recently, neither of these statements was readily applicable to the class of resistance mechanism known as target protection, a phenomenon whereby a resistance protein physically associates with an antibiotic target to rescue it from antibiotic-mediated inhibition. In this Review, we summarize recent progress in understanding the nature and importance of target protection. In particular, we describe the molecular basis of the known target protection systems, emphasizing that target protection does not involve a single, uniform mechanism but is instead brought about in several mechanistically distinct ways.
(Less)
- author
- Wilson, Daniel N.
; Hauryliuk, Vasili
LU
; Atkinson, Gemma C. LU and O’Neill, Alex J.
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- in
- Nature Reviews Microbiology
- volume
- 18
- issue
- 11
- pages
- 637 - 648
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85087090075
- pmid:32587401
- ISSN
- 1740-1526
- DOI
- 10.1038/s41579-020-0386-z
- language
- English
- LU publication?
- no
- additional info
- Funding Information: Work on ribosome protection by the D.N.W. group is supported by Deutsche Forschungsgemeinschaft grants (WI3285/8-1 to D.N.W.), and studies in A.J.O.’s laboratory have been supported by the UK Biotechnology and Biological Sciences Research Council (grants BB/H018433/1 and BB/F016603/1). Antibiotic resistance studies in the D.N.W. and V.H. groups are also supported by the Deutsche Zentrum für Luft-und Raumfahrt (DLR01Kl1820 to D.N.W) and the Swedish Research Council (2018-00956 to V.H.) within the RIBOTARGET consortium under the frame of JPIAMR. The Swedish Research Council supports V.H. and G.C.A. (2017-03783 to V.H. and 2015-04746 and 2019-01085 to G.C.A.). Additional support to V.H. comes from the Ragnar Söderbergs Stiftelse, the European Regional Development Fund through the Centre of Excellence for Molecular Cell Engineering, Molecular Infection Medicine Sweden, and the Estonian Science Foundation (IUT2-22). G.C.A. is also supported by the Carl Tryggers Stiftelse förVetensk-aplig Forskning (CTS 19:24), Kempestiftelserna(SMK-1858.3), Jeanssons Stiftelser, the Umeå Centre for Microbial Research gender policy programme and Umeå Universitet Insamlingsstiftelsen för Medicinsk Forskning. Publisher Copyright: © 2020, Springer Nature Limited. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
- id
- 48db5311-ff74-4491-b5bb-a6fa7452d156
- date added to LUP
- 2021-09-24 20:32:01
- date last changed
- 2024-06-16 19:29:21
@article{48db5311-ff74-4491-b5bb-a6fa7452d156, abstract = {{<p>Antibiotic resistance is mediated through several distinct mechanisms, most of which are relatively well understood and the clinical importance of which has long been recognized. Until very recently, neither of these statements was readily applicable to the class of resistance mechanism known as target protection, a phenomenon whereby a resistance protein physically associates with an antibiotic target to rescue it from antibiotic-mediated inhibition. In this Review, we summarize recent progress in understanding the nature and importance of target protection. In particular, we describe the molecular basis of the known target protection systems, emphasizing that target protection does not involve a single, uniform mechanism but is instead brought about in several mechanistically distinct ways.</p>}}, author = {{Wilson, Daniel N. and Hauryliuk, Vasili and Atkinson, Gemma C. and O’Neill, Alex J.}}, issn = {{1740-1526}}, language = {{eng}}, number = {{11}}, pages = {{637--648}}, publisher = {{Nature Publishing Group}}, series = {{Nature Reviews Microbiology}}, title = {{Target protection as a key antibiotic resistance mechanism}}, url = {{http://dx.doi.org/10.1038/s41579-020-0386-z}}, doi = {{10.1038/s41579-020-0386-z}}, volume = {{18}}, year = {{2020}}, }