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Concise Review: Hematopoietic Stem Cell Aging and the Prospects for Rejuvenation.

Wahlestedt, Martin LU ; Pronk, Cornelis Jan and Bryder, David LU (2015) In Stem cells translational medicine 4(2). p.186-194
Abstract
Because of the continuous increases in lifetime expectancy, the incidence of age-related diseases will, unless counteracted, represent an increasing problem at both the individual and socioeconomic levels. Studies on the processes of blood cell formation have revealed several shortcomings as a consequence of chronological age. They include a reduced ability to mount adaptive immune responses and a blood cell composition skewed toward myeloid cells, with the latter coinciding with a dramatically increased incidence of myelogenous diseases, including cancer. Conversely, the dominant forms of acute leukemia affecting children associate with the lymphoid lineages. A growing body of evidence has suggested that aging of various organs and... (More)
Because of the continuous increases in lifetime expectancy, the incidence of age-related diseases will, unless counteracted, represent an increasing problem at both the individual and socioeconomic levels. Studies on the processes of blood cell formation have revealed several shortcomings as a consequence of chronological age. They include a reduced ability to mount adaptive immune responses and a blood cell composition skewed toward myeloid cells, with the latter coinciding with a dramatically increased incidence of myelogenous diseases, including cancer. Conversely, the dominant forms of acute leukemia affecting children associate with the lymphoid lineages. A growing body of evidence has suggested that aging of various organs and cellular systems, including the hematopoietic system, associates with a functional demise of tissue-resident stem cell populations. Mechanistically, DNA damage and/or altered transcriptional landscapes appear to be major drivers of the hematopoietic stem cell aging state, with recent data proposing that stem cell aging phenotypes are characterized by at least some degree of reversibility. These findings suggest the possibility of rejuvenating, or at least dampening, stem cell aging phenotypes in the elderly for therapeutic benefit. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Stem cells translational medicine
volume
4
issue
2
pages
186 - 194
publisher
AlphaMed Press
external identifiers
  • pmid:25548388
  • wos:000348967900009
  • scopus:84921780256
ISSN
2157-6580
DOI
10.5966/sctm.2014-0132
language
English
LU publication?
yes
id
65c27483-f4b1-4d83-a613-491996dce1e9 (old id 4905469)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25548388?dopt=Abstract
date added to LUP
2015-01-06 11:18:03
date last changed
2017-01-01 04:13:12
@article{65c27483-f4b1-4d83-a613-491996dce1e9,
  abstract     = {Because of the continuous increases in lifetime expectancy, the incidence of age-related diseases will, unless counteracted, represent an increasing problem at both the individual and socioeconomic levels. Studies on the processes of blood cell formation have revealed several shortcomings as a consequence of chronological age. They include a reduced ability to mount adaptive immune responses and a blood cell composition skewed toward myeloid cells, with the latter coinciding with a dramatically increased incidence of myelogenous diseases, including cancer. Conversely, the dominant forms of acute leukemia affecting children associate with the lymphoid lineages. A growing body of evidence has suggested that aging of various organs and cellular systems, including the hematopoietic system, associates with a functional demise of tissue-resident stem cell populations. Mechanistically, DNA damage and/or altered transcriptional landscapes appear to be major drivers of the hematopoietic stem cell aging state, with recent data proposing that stem cell aging phenotypes are characterized by at least some degree of reversibility. These findings suggest the possibility of rejuvenating, or at least dampening, stem cell aging phenotypes in the elderly for therapeutic benefit.},
  author       = {Wahlestedt, Martin and Pronk, Cornelis Jan and Bryder, David},
  issn         = {2157-6580},
  language     = {eng},
  number       = {2},
  pages        = {186--194},
  publisher    = {AlphaMed Press},
  series       = {Stem cells translational medicine},
  title        = {Concise Review: Hematopoietic Stem Cell Aging and the Prospects for Rejuvenation.},
  url          = {http://dx.doi.org/10.5966/sctm.2014-0132},
  volume       = {4},
  year         = {2015},
}