Size-dependent long-term tissue response to biostable nanowires in the brain.
Gällentoft, Lina LU ; Pettersson, Lina LU ; Danielsen, Nils LU ; Schouenborg, Jens LU
; Prinz, Christelle
LU
and Eriksson Linsmeier, Cecilia
LU
(2015)
In Biomaterials
42.
p.172-183
- Abstract
- Nanostructured neural interfaces, comprising nanotubes or nanowires, have the potential to overcome the present hurdles of achieving stable communication with neuronal networks for long periods of time. This would have a strong impact on brain research. However, little information is available on the brain response to implanted high-aspect-ratio nanoparticles, which share morphological similarities with asbestos fibres. Here, we investigated the glial response and neuronal loss in the rat brain after implantation of biostable and structurally controlled nanowires of different lengths for a period up to one year post-surgery. Our results show that, as for lung and abdominal tissue, the brain is subject to a sustained, local inflammation... (More)
- Nanostructured neural interfaces, comprising nanotubes or nanowires, have the potential to overcome the present hurdles of achieving stable communication with neuronal networks for long periods of time. This would have a strong impact on brain research. However, little information is available on the brain response to implanted high-aspect-ratio nanoparticles, which share morphological similarities with asbestos fibres. Here, we investigated the glial response and neuronal loss in the rat brain after implantation of biostable and structurally controlled nanowires of different lengths for a period up to one year post-surgery. Our results show that, as for lung and abdominal tissue, the brain is subject to a sustained, local inflammation when biostable and high-aspect-ratio nanoparticles of 5 μm or longer are present in the brain tissue. In addition, a significant loss of neurons was observed adjacent to the 10 μm nanowires after one year. Notably, the inflammatory response was restricted to a narrow zone around the nanowires and did not escalate between 12 weeks and one year. Furthermore, 2 μm nanowires did not cause significant inflammatory response nor significant loss of neurons nearby. The present results provide key information for the design of future neural implants based on nanomaterials. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4905601
- author
- Gällentoft, Lina
LU
; Pettersson, Lina
LU
; Danielsen, Nils
LU
; Schouenborg, Jens
LU
; Prinz, Christelle
LU
and Eriksson Linsmeier, Cecilia
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biomaterials
- volume
- 42
- pages
- 172 - 183
- publisher
- Elsevier
- external identifiers
-
- pmid:25542805
- wos:000348883700018
- scopus:84919654275
- pmid:25542805
- ISSN
- 1878-5905
- DOI
- 10.1016/j.biomaterials.2014.11.051
- project
- Vävnadsreaktioner i nervsystemet efter elektrodimplantation
- language
- English
- LU publication?
- yes
- id
- ad4f12be-ffa6-4b8d-9cb7-85a7753c8dc0 (old id 4905601)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25542805?dopt=Abstract
- date added to LUP
- 2016-04-01 10:49:36
- date last changed
- 2024-05-05 22:38:25
@article{ad4f12be-ffa6-4b8d-9cb7-85a7753c8dc0,
abstract = {{Nanostructured neural interfaces, comprising nanotubes or nanowires, have the potential to overcome the present hurdles of achieving stable communication with neuronal networks for long periods of time. This would have a strong impact on brain research. However, little information is available on the brain response to implanted high-aspect-ratio nanoparticles, which share morphological similarities with asbestos fibres. Here, we investigated the glial response and neuronal loss in the rat brain after implantation of biostable and structurally controlled nanowires of different lengths for a period up to one year post-surgery. Our results show that, as for lung and abdominal tissue, the brain is subject to a sustained, local inflammation when biostable and high-aspect-ratio nanoparticles of 5 μm or longer are present in the brain tissue. In addition, a significant loss of neurons was observed adjacent to the 10 μm nanowires after one year. Notably, the inflammatory response was restricted to a narrow zone around the nanowires and did not escalate between 12 weeks and one year. Furthermore, 2 μm nanowires did not cause significant inflammatory response nor significant loss of neurons nearby. The present results provide key information for the design of future neural implants based on nanomaterials.}},
author = {{Gällentoft, Lina and Pettersson, Lina and Danielsen, Nils and Schouenborg, Jens and Prinz, Christelle and Eriksson Linsmeier, Cecilia}},
issn = {{1878-5905}},
language = {{eng}},
pages = {{172--183}},
publisher = {{Elsevier}},
series = {{Biomaterials}},
title = {{Size-dependent long-term tissue response to biostable nanowires in the brain.}},
url = {{http://dx.doi.org/10.1016/j.biomaterials.2014.11.051}},
doi = {{10.1016/j.biomaterials.2014.11.051}},
volume = {{42}},
year = {{2015}},
}