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Characterization of heme binding to recombinant α1-microglobulin.

Karnaukhova, Elena; Rutardottir, Sigurbjörg LU ; Rajabi, Mohsen; Wester Rosenlöf, Lena LU ; Alayash, Abdu I and Åkerström, Bo LU (2014) In Frontiers in Physiology 5.
Abstract
Alpha-1-microglobulin (A1M), a small lipocalin protein found in plasma and tissues, has been identified as a heme and radical scavenger that may participate in the mitigation of toxicities caused by degradation of hemoglobin. The objective of this work was to investigate heme interactions with A1M in vitro using various analytical techniques and to optimize analytical methodology suitable for rapid evaluation of the ligand binding properties of recombinant A1M versions.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Frontiers in Physiology
volume
5
publisher
Frontiers
external identifiers
  • pmid:25538624
  • wos:000347806900002
  • scopus:84912001736
ISSN
1664-042X
DOI
10.3389/fphys.2014.00465
language
English
LU publication?
yes
id
5e2745ba-ff4a-4040-b6cf-9cae9a51d2bc (old id 4905665)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25538624?dopt=Abstract
date added to LUP
2015-01-07 13:42:48
date last changed
2017-10-01 04:00:12
@article{5e2745ba-ff4a-4040-b6cf-9cae9a51d2bc,
  abstract     = {Alpha-1-microglobulin (A1M), a small lipocalin protein found in plasma and tissues, has been identified as a heme and radical scavenger that may participate in the mitigation of toxicities caused by degradation of hemoglobin. The objective of this work was to investigate heme interactions with A1M in vitro using various analytical techniques and to optimize analytical methodology suitable for rapid evaluation of the ligand binding properties of recombinant A1M versions.},
  articleno    = {465},
  author       = {Karnaukhova, Elena and Rutardottir, Sigurbjörg and Rajabi, Mohsen and Wester Rosenlöf, Lena and Alayash, Abdu I and Åkerström, Bo},
  issn         = {1664-042X},
  language     = {eng},
  publisher    = {Frontiers},
  series       = {Frontiers in Physiology},
  title        = {Characterization of heme binding to recombinant α1-microglobulin.},
  url          = {http://dx.doi.org/10.3389/fphys.2014.00465},
  volume       = {5},
  year         = {2014},
}