Characterization of heme binding to recombinant α1-microglobulin.
(2014) In Frontiers in Physiology 5.- Abstract
- Alpha-1-microglobulin (A1M), a small lipocalin protein found in plasma and tissues, has been identified as a heme and radical scavenger that may participate in the mitigation of toxicities caused by degradation of hemoglobin. The objective of this work was to investigate heme interactions with A1M in vitro using various analytical techniques and to optimize analytical methodology suitable for rapid evaluation of the ligand binding properties of recombinant A1M versions.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4905665
- author
- Karnaukhova, Elena ; Rutardottir, Sigurbjörg LU ; Rajabi, Mohsen ; Wester Rosenlöf, Lena LU ; Alayash, Abdu I and Åkerström, Bo LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Frontiers in Physiology
- volume
- 5
- article number
- 465
- publisher
- Frontiers Media S. A.
- external identifiers
-
- pmid:25538624
- wos:000347806900002
- scopus:84912001736
- pmid:25538624
- ISSN
- 1664-042X
- DOI
- 10.3389/fphys.2014.00465
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Infection Medicine (BMC) (013024020), Medical Inflammation Research (013212019)
- id
- 5e2745ba-ff4a-4040-b6cf-9cae9a51d2bc (old id 4905665)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25538624?dopt=Abstract
- date added to LUP
- 2016-04-01 12:55:11
- date last changed
- 2022-03-29 04:32:42
@article{5e2745ba-ff4a-4040-b6cf-9cae9a51d2bc, abstract = {{Alpha-1-microglobulin (A1M), a small lipocalin protein found in plasma and tissues, has been identified as a heme and radical scavenger that may participate in the mitigation of toxicities caused by degradation of hemoglobin. The objective of this work was to investigate heme interactions with A1M in vitro using various analytical techniques and to optimize analytical methodology suitable for rapid evaluation of the ligand binding properties of recombinant A1M versions.}}, author = {{Karnaukhova, Elena and Rutardottir, Sigurbjörg and Rajabi, Mohsen and Wester Rosenlöf, Lena and Alayash, Abdu I and Åkerström, Bo}}, issn = {{1664-042X}}, language = {{eng}}, publisher = {{Frontiers Media S. A.}}, series = {{Frontiers in Physiology}}, title = {{Characterization of heme binding to recombinant α1-microglobulin.}}, url = {{https://lup.lub.lu.se/search/files/3045703/7760081.pdf}}, doi = {{10.3389/fphys.2014.00465}}, volume = {{5}}, year = {{2014}}, }