Longitudinal assessment of femoral knee cartilage quality using contrast enhanced MRI (dGEMRIC) in patients with anterior cruciate ligament injury - comparison with asymptomatic volunteers.
Neuman, Paul LU ; Tjörnstrand, Jon LU ; Svensson, Jonas LU ; Ragnarsson, C ; Roos, Harald LU ; Englund, Martin LU
; Tiderius, Carl Johan
LU
and Dahlberg, Leif
LU
(2011)
In Osteoarthritis and Cartilage
19.
p.977-983
- Abstract
- OBJECTIVE: In this observational longitudinal study we estimate knee joint cartilage glycosaminoglycan (GAG) content, in patients with an acute anterior cruciate ligament (ACL) injury, with or without a concomitant meniscus injury. METHODS: 29 knees (19 men/10 women) were prospectively examined by repeat delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC), approximately 3 weeks and 2.3±1.3 (range 4.5) years after the injury. We estimated the GAG content (T1Gd) in the central weight-bearing parts of the medial and lateral femoral cartilage and compared results with a reference cohort (n=24) with normal knees and no history of injury examined by dGEMRIC at one occasion previously. RESULTS: The healthy reference... (More)
- OBJECTIVE: In this observational longitudinal study we estimate knee joint cartilage glycosaminoglycan (GAG) content, in patients with an acute anterior cruciate ligament (ACL) injury, with or without a concomitant meniscus injury. METHODS: 29 knees (19 men/10 women) were prospectively examined by repeat delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC), approximately 3 weeks and 2.3±1.3 (range 4.5) years after the injury. We estimated the GAG content (T1Gd) in the central weight-bearing parts of the medial and lateral femoral cartilage and compared results with a reference cohort (n=24) with normal knees and no history of injury examined by dGEMRIC at one occasion previously. RESULTS: The healthy reference group had longer T1Gd values compared with the ACL-injured patients at follow-up both medially: 428±38 vs 363±61ms (P<0.0001) and laterally: 445±41 vs 396±48ms (P=0.0002). At follow-up T1Gd was lower in meniscectomized patients compared to those without a meniscectomy, both medially (-84ms, P=0.002) and laterally (-38ms, P=0.05). In the injured group, the medial femoral cartilage showed similar T1Gd at the two dGEMRIC investigations: 357±50 vs 363±61ms (P=0.57), whereas the lateral femoral cartilage T1Gd increased: 374±48 vs 396±48ms (P=0.04). CONCLUSIONS: The general decrease in cartilage T1Gd in ACL-injured patients compared with references provide evidence for structural matrix GAG changes that seem more pronounced if a concomitant meniscal injury is present. The fact that post-traumatic OA commonly develops in ACL-injured patients, in particularly those with meniscectomy, suggests that shorter T1Gd may be an early biomarker for OA. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1971950
- author
- Neuman, Paul
LU
; Tjörnstrand, Jon
LU
; Svensson, Jonas
LU
; Ragnarsson, C
; Roos, Harald
LU
; Englund, Martin
LU
; Tiderius, Carl Johan
LU
and Dahlberg, Leif
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Osteoarthritis and Cartilage
- volume
- 19
- pages
- 977 - 983
- publisher
- Elsevier
- external identifiers
-
- wos:000294240400007
- pmid:21621622
- scopus:79960287232
- ISSN
- 1063-4584
- DOI
- 10.1016/j.joca.2011.05.002
- language
- English
- LU publication?
- yes
- id
- 490592d8-db3d-4b69-8f5d-1a58682a80dc (old id 1971950)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21621622?dopt=Abstract
- date added to LUP
- 2016-04-04 07:59:41
- date last changed
- 2022-02-28 04:18:16
@article{490592d8-db3d-4b69-8f5d-1a58682a80dc,
abstract = {{OBJECTIVE: In this observational longitudinal study we estimate knee joint cartilage glycosaminoglycan (GAG) content, in patients with an acute anterior cruciate ligament (ACL) injury, with or without a concomitant meniscus injury. METHODS: 29 knees (19 men/10 women) were prospectively examined by repeat delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC), approximately 3 weeks and 2.3±1.3 (range 4.5) years after the injury. We estimated the GAG content (T1Gd) in the central weight-bearing parts of the medial and lateral femoral cartilage and compared results with a reference cohort (n=24) with normal knees and no history of injury examined by dGEMRIC at one occasion previously. RESULTS: The healthy reference group had longer T1Gd values compared with the ACL-injured patients at follow-up both medially: 428±38 vs 363±61ms (P<0.0001) and laterally: 445±41 vs 396±48ms (P=0.0002). At follow-up T1Gd was lower in meniscectomized patients compared to those without a meniscectomy, both medially (-84ms, P=0.002) and laterally (-38ms, P=0.05). In the injured group, the medial femoral cartilage showed similar T1Gd at the two dGEMRIC investigations: 357±50 vs 363±61ms (P=0.57), whereas the lateral femoral cartilage T1Gd increased: 374±48 vs 396±48ms (P=0.04). CONCLUSIONS: The general decrease in cartilage T1Gd in ACL-injured patients compared with references provide evidence for structural matrix GAG changes that seem more pronounced if a concomitant meniscal injury is present. The fact that post-traumatic OA commonly develops in ACL-injured patients, in particularly those with meniscectomy, suggests that shorter T1Gd may be an early biomarker for OA.}},
author = {{Neuman, Paul and Tjörnstrand, Jon and Svensson, Jonas and Ragnarsson, C and Roos, Harald and Englund, Martin and Tiderius, Carl Johan and Dahlberg, Leif}},
issn = {{1063-4584}},
language = {{eng}},
pages = {{977--983}},
publisher = {{Elsevier}},
series = {{Osteoarthritis and Cartilage}},
title = {{Longitudinal assessment of femoral knee cartilage quality using contrast enhanced MRI (dGEMRIC) in patients with anterior cruciate ligament injury - comparison with asymptomatic volunteers.}},
url = {{http://dx.doi.org/10.1016/j.joca.2011.05.002}},
doi = {{10.1016/j.joca.2011.05.002}},
volume = {{19}},
year = {{2011}},
}