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Perinatal And Familial Risk Factors For Brain Tumors in Childhood Through Young Adulthood.

Crump, Casey LU ; Sundquist, Jan LU ; Sieh, Weiva; Winkleby, Marilyn A and Sundquist, Kristina LU (2015) In Cancer Research 75(3). p.576-583
Abstract
Perinatal factors including high birth weight have been associated with childhood brain tumors in case-control studies. However, the specific contributions of gestational age and fetal growth remain unknown, and these issues have never been examined in large cohort studies with follow-up into adulthood. We conducted a national cohort study of 3,571,574 persons born in Sweden in 1973-2008, followed up for brain tumor incidence through 2010 (maximum age 38 years) to examine perinatal and familial risk factors. There were 2,809 brain tumors in 69.7 million person-years of follow-up. After adjusting for potential confounders, significant risk factors for brain tumors included high fetal growth (incidence rate ratio [IRR] per additional 1... (More)
Perinatal factors including high birth weight have been associated with childhood brain tumors in case-control studies. However, the specific contributions of gestational age and fetal growth remain unknown, and these issues have never been examined in large cohort studies with follow-up into adulthood. We conducted a national cohort study of 3,571,574 persons born in Sweden in 1973-2008, followed up for brain tumor incidence through 2010 (maximum age 38 years) to examine perinatal and familial risk factors. There were 2,809 brain tumors in 69.7 million person-years of follow-up. After adjusting for potential confounders, significant risk factors for brain tumors included high fetal growth (incidence rate ratio [IRR] per additional 1 standard deviation, 1.04; 95% CI, 1.01-1.08, P=0.02), first-degree family history of a brain tumor (IRR, 2.43; 95% CI, 1.86-3.18, P<0.001), parental country of birth (IRR for both parents born in Sweden vs. other countries, 1.21; 95% CI, 1.09-1.35, P<0.001), and high maternal education level (Ptrend=0.01). These risk factors did not vary by age at diagnosis. The association with high fetal growth appeared to involve pilocytic astrocytomas, but not other astrocytomas, medulloblastomas, or ependymomas. Gestational age at birth, birth order, multiple birth, and parental age were not associated with brain tumors. In this large cohort study, high fetal growth was associated with an increased risk of brain tumors (particularly pilocytic astrocytomas) independently of gestational age, not only in childhood but also into young adulthood, suggesting that growth factor pathways may play an important long-term role in the etiology of certain brain tumor subtypes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Research
volume
75
issue
3
pages
576 - 583
publisher
American Association for Cancer Research Inc.
external identifiers
  • pmid:25511376
  • wos:000349841200011
  • scopus:84922171145
ISSN
1538-7445
DOI
10.1158/0008-5472.CAN-14-2285
language
English
LU publication?
yes
id
fd8fb8d8-f4c9-41ac-ad74-532e413bcf30 (old id 4908196)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25511376?dopt=Abstract
date added to LUP
2015-01-07 16:32:02
date last changed
2017-10-01 03:15:46
@article{fd8fb8d8-f4c9-41ac-ad74-532e413bcf30,
  abstract     = {Perinatal factors including high birth weight have been associated with childhood brain tumors in case-control studies. However, the specific contributions of gestational age and fetal growth remain unknown, and these issues have never been examined in large cohort studies with follow-up into adulthood. We conducted a national cohort study of 3,571,574 persons born in Sweden in 1973-2008, followed up for brain tumor incidence through 2010 (maximum age 38 years) to examine perinatal and familial risk factors. There were 2,809 brain tumors in 69.7 million person-years of follow-up. After adjusting for potential confounders, significant risk factors for brain tumors included high fetal growth (incidence rate ratio [IRR] per additional 1 standard deviation, 1.04; 95% CI, 1.01-1.08, P=0.02), first-degree family history of a brain tumor (IRR, 2.43; 95% CI, 1.86-3.18, P&lt;0.001), parental country of birth (IRR for both parents born in Sweden vs. other countries, 1.21; 95% CI, 1.09-1.35, P&lt;0.001), and high maternal education level (Ptrend=0.01). These risk factors did not vary by age at diagnosis. The association with high fetal growth appeared to involve pilocytic astrocytomas, but not other astrocytomas, medulloblastomas, or ependymomas. Gestational age at birth, birth order, multiple birth, and parental age were not associated with brain tumors. In this large cohort study, high fetal growth was associated with an increased risk of brain tumors (particularly pilocytic astrocytomas) independently of gestational age, not only in childhood but also into young adulthood, suggesting that growth factor pathways may play an important long-term role in the etiology of certain brain tumor subtypes.},
  author       = {Crump, Casey and Sundquist, Jan and Sieh, Weiva and Winkleby, Marilyn A and Sundquist, Kristina},
  issn         = {1538-7445},
  language     = {eng},
  number       = {3},
  pages        = {576--583},
  publisher    = {American Association for Cancer Research Inc.},
  series       = {Cancer Research},
  title        = {Perinatal And Familial Risk Factors For Brain Tumors in Childhood Through Young Adulthood.},
  url          = {http://dx.doi.org/10.1158/0008-5472.CAN-14-2285},
  volume       = {75},
  year         = {2015},
}