CaMKII inhibition with KN93 attenuates endothelin and serotonin receptor-mediated vasoconstriction and prevents subarachnoid hemorrhage-induced deficits in sensorimotor function.
(2014) In Journal of Neuroinflammation 11.- Abstract
- It has been suggested that transcriptional upregulation of cerebral artery contractile endothelin (ETB) and 5-hydroxytryptamine (5-HT1B) receptors play an important role in the development of late cerebral ischemia and increased vasoconstriction after subarachnoid hemorrhage (SAH). We tested the hypothesis that inhibition of calcium calmodulin-dependent protein kinase II (CaMKII) may reduce cerebral vasoconstriction mediated by endothelin and serotonin receptors and improve neurological outcome after experimental SAH.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4908507
- author
- Edvinsson, Lars LU ; Povlsen, Gro Klitgaard ; Ahnstedt, Hilda LU and Waldsee, Roya LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Neuroinflammation
- volume
- 11
- article number
- 207
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:25498987
- wos:000347117200001
- scopus:84924916149
- ISSN
- 1742-2094
- DOI
- 10.1186/s12974-014-0207-2
- language
- English
- LU publication?
- yes
- id
- 5a7ed397-d499-4c32-aaef-72c01477fd4e (old id 4908507)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25498987?dopt=Abstract
- date added to LUP
- 2016-04-01 14:31:29
- date last changed
- 2024-10-10 17:58:45
@article{5a7ed397-d499-4c32-aaef-72c01477fd4e, abstract = {{It has been suggested that transcriptional upregulation of cerebral artery contractile endothelin (ETB) and 5-hydroxytryptamine (5-HT1B) receptors play an important role in the development of late cerebral ischemia and increased vasoconstriction after subarachnoid hemorrhage (SAH). We tested the hypothesis that inhibition of calcium calmodulin-dependent protein kinase II (CaMKII) may reduce cerebral vasoconstriction mediated by endothelin and serotonin receptors and improve neurological outcome after experimental SAH.}}, author = {{Edvinsson, Lars and Povlsen, Gro Klitgaard and Ahnstedt, Hilda and Waldsee, Roya}}, issn = {{1742-2094}}, language = {{eng}}, publisher = {{BioMed Central (BMC)}}, series = {{Journal of Neuroinflammation}}, title = {{CaMKII inhibition with KN93 attenuates endothelin and serotonin receptor-mediated vasoconstriction and prevents subarachnoid hemorrhage-induced deficits in sensorimotor function.}}, url = {{https://lup.lub.lu.se/search/files/4019419/7751675}}, doi = {{10.1186/s12974-014-0207-2}}, volume = {{11}}, year = {{2014}}, }