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CaMKII inhibition with KN93 attenuates endothelin and serotonin receptor-mediated vasoconstriction and prevents subarachnoid hemorrhage-induced deficits in sensorimotor function.

Edvinsson, Lars LU ; Povlsen, Gro Klitgaard; Ahnstedt, Hilda LU and Waldsee, Roya LU (2014) In Journal of Neuroinflammation 11.
Abstract
It has been suggested that transcriptional upregulation of cerebral artery contractile endothelin (ETB) and 5-hydroxytryptamine (5-HT1B) receptors play an important role in the development of late cerebral ischemia and increased vasoconstriction after subarachnoid hemorrhage (SAH). We tested the hypothesis that inhibition of calcium calmodulin-dependent protein kinase II (CaMKII) may reduce cerebral vasoconstriction mediated by endothelin and serotonin receptors and improve neurological outcome after experimental SAH.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neuroinflammation
volume
11
publisher
BioMed Central
external identifiers
  • pmid:25498987
  • wos:000347117200001
  • scopus:84924916149
ISSN
1742-2094
DOI
10.1186/s12974-014-0207-2
language
English
LU publication?
yes
id
5a7ed397-d499-4c32-aaef-72c01477fd4e (old id 4908507)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25498987?dopt=Abstract
date added to LUP
2015-01-11 19:03:37
date last changed
2017-01-01 06:17:10
@article{5a7ed397-d499-4c32-aaef-72c01477fd4e,
  abstract     = {It has been suggested that transcriptional upregulation of cerebral artery contractile endothelin (ETB) and 5-hydroxytryptamine (5-HT1B) receptors play an important role in the development of late cerebral ischemia and increased vasoconstriction after subarachnoid hemorrhage (SAH). We tested the hypothesis that inhibition of calcium calmodulin-dependent protein kinase II (CaMKII) may reduce cerebral vasoconstriction mediated by endothelin and serotonin receptors and improve neurological outcome after experimental SAH.},
  articleno    = {207},
  author       = {Edvinsson, Lars and Povlsen, Gro Klitgaard and Ahnstedt, Hilda and Waldsee, Roya},
  issn         = {1742-2094},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {Journal of Neuroinflammation},
  title        = {CaMKII inhibition with KN93 attenuates endothelin and serotonin receptor-mediated vasoconstriction and prevents subarachnoid hemorrhage-induced deficits in sensorimotor function.},
  url          = {http://dx.doi.org/10.1186/s12974-014-0207-2},
  volume       = {11},
  year         = {2014},
}