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Depressive symptomatology in severe dementia in a European sample: prevalence, associated factors and prescription rate of antidepressants.

Giebel, Clarissa M; Sutcliffe, Caroline; Renom-Guiteras, Anna; Arve, Seija; Rahm Hallberg, Ingalill LU ; Soto, Maria; Zabalegui, Adelaida; Hamers, Jan; Saks, Kai and Challis, David (2015) In International Psychogeriatrics 27(4). p.657-667
Abstract
ABSTRACT Background: Depression is a common comorbid disorder of dementia. This study explores the prevalence of and factors associated with depressive symptomatology, and antidepressant prescription rates in severe dementia across eight European countries. Methods: In total, 414 people with severe dementia completed measures of cognition and quality of life (QoL), whilst carers completed proxy measures of activities of daily living (ADLs), depression, neuropsychiatric symptoms, QoL and comorbidity. Results: Findings indicated that 30% of the sample had depression, whilst the highest and lowest prevalence of depression was reported in Germany and Finland, respectively. Lower QoL, the presence of pain and more frequent neuropsychiatric... (More)
ABSTRACT Background: Depression is a common comorbid disorder of dementia. This study explores the prevalence of and factors associated with depressive symptomatology, and antidepressant prescription rates in severe dementia across eight European countries. Methods: In total, 414 people with severe dementia completed measures of cognition and quality of life (QoL), whilst carers completed proxy measures of activities of daily living (ADLs), depression, neuropsychiatric symptoms, QoL and comorbidity. Results: Findings indicated that 30% of the sample had depression, whilst the highest and lowest prevalence of depression was reported in Germany and Finland, respectively. Lower QoL, the presence of pain and more frequent neuropsychiatric symptoms were associated with depressive symptomatology, whilst no significant relationship between impairment of ADLs, comorbidity, and depression emerged. Spain and Estonia had the highest and lowest rates of antidepressant prescribing, respectively, whilst Germany had the highest discrepancy between depressive symptomatology and prescription. Conclusions: The study highlights variations across countries in the prevalence of depressive symptomatology in severe dementia and prescription of antidepressants. Information about factors associated with depressive symptomatology may help to better identify and manage depression. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Psychogeriatrics
volume
27
issue
4
pages
657 - 667
publisher
Cambridge University Press
external identifiers
  • pmid:25497829
  • wos:000351058200014
  • scopus:84924333623
ISSN
1741-203X
DOI
10.1017/S1041610214002610
language
English
LU publication?
yes
id
489bfd6f-2770-4e90-94ac-d12111ba057d (old id 4908537)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25497829?dopt=Abstract
date added to LUP
2015-01-10 18:19:43
date last changed
2017-01-01 04:01:39
@article{489bfd6f-2770-4e90-94ac-d12111ba057d,
  abstract     = {ABSTRACT Background: Depression is a common comorbid disorder of dementia. This study explores the prevalence of and factors associated with depressive symptomatology, and antidepressant prescription rates in severe dementia across eight European countries. Methods: In total, 414 people with severe dementia completed measures of cognition and quality of life (QoL), whilst carers completed proxy measures of activities of daily living (ADLs), depression, neuropsychiatric symptoms, QoL and comorbidity. Results: Findings indicated that 30% of the sample had depression, whilst the highest and lowest prevalence of depression was reported in Germany and Finland, respectively. Lower QoL, the presence of pain and more frequent neuropsychiatric symptoms were associated with depressive symptomatology, whilst no significant relationship between impairment of ADLs, comorbidity, and depression emerged. Spain and Estonia had the highest and lowest rates of antidepressant prescribing, respectively, whilst Germany had the highest discrepancy between depressive symptomatology and prescription. Conclusions: The study highlights variations across countries in the prevalence of depressive symptomatology in severe dementia and prescription of antidepressants. Information about factors associated with depressive symptomatology may help to better identify and manage depression.},
  author       = {Giebel, Clarissa M and Sutcliffe, Caroline and Renom-Guiteras, Anna and Arve, Seija and Rahm Hallberg, Ingalill and Soto, Maria and Zabalegui, Adelaida and Hamers, Jan and Saks, Kai and Challis, David},
  issn         = {1741-203X},
  language     = {eng},
  number       = {4},
  pages        = {657--667},
  publisher    = {Cambridge University Press},
  series       = {International Psychogeriatrics},
  title        = {Depressive symptomatology in severe dementia in a European sample: prevalence, associated factors and prescription rate of antidepressants.},
  url          = {http://dx.doi.org/10.1017/S1041610214002610},
  volume       = {27},
  year         = {2015},
}