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Lipopolysaccharide-Induced Loss of Cultured Rat Myenteric Neurons - Role of AMP-Activated Protein Kinase.

Voss, Ulrikke LU and Ekblad, Eva LU (2014) In PLoS ONE 9(12).
Abstract
Intestinal barrier function is vital for homeostasis. Conditions where the mucosal barrier is compromised lead to increased plasma content of lipopolysaccharide (LPS). LPS acts on Toll-like receptor 4 (TLR4) and initiates cellular inflammatory responses. TLR4 receptors have been identified on enteric neurons and LPS exposure causes neuronal loss, counteracted by vasoactive intestinal peptide (VIP), by unknown mechanisms. In addition AMP activated protein kinase (AMPK) stimulation causes loss of enteric neurons. This study investigated a possible role of AMPK activation in LPS-induced neuronal loss.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
9
issue
12
publisher
Public Library of Science
external identifiers
  • pmid:25462874
  • wos:000345869700087
  • scopus:84914665563
ISSN
1932-6203
DOI
10.1371/journal.pone.0114044
language
English
LU publication?
yes
id
6d99603c-9b6f-401b-ad04-9421751bac3d (old id 4912964)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25462874?dopt=Abstract
date added to LUP
2015-01-08 18:28:57
date last changed
2017-04-16 04:02:04
@article{6d99603c-9b6f-401b-ad04-9421751bac3d,
  abstract     = {Intestinal barrier function is vital for homeostasis. Conditions where the mucosal barrier is compromised lead to increased plasma content of lipopolysaccharide (LPS). LPS acts on Toll-like receptor 4 (TLR4) and initiates cellular inflammatory responses. TLR4 receptors have been identified on enteric neurons and LPS exposure causes neuronal loss, counteracted by vasoactive intestinal peptide (VIP), by unknown mechanisms. In addition AMP activated protein kinase (AMPK) stimulation causes loss of enteric neurons. This study investigated a possible role of AMPK activation in LPS-induced neuronal loss.},
  articleno    = {e114044},
  author       = {Voss, Ulrikke and Ekblad, Eva},
  issn         = {1932-6203},
  language     = {eng},
  number       = {12},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Lipopolysaccharide-Induced Loss of Cultured Rat Myenteric Neurons - Role of AMP-Activated Protein Kinase.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0114044},
  volume       = {9},
  year         = {2014},
}