Lipopolysaccharide-Induced Loss of Cultured Rat Myenteric Neurons - Role of AMP-Activated Protein Kinase.
(2014) In PLoS ONE 9(12).- Abstract
- Intestinal barrier function is vital for homeostasis. Conditions where the mucosal barrier is compromised lead to increased plasma content of lipopolysaccharide (LPS). LPS acts on Toll-like receptor 4 (TLR4) and initiates cellular inflammatory responses. TLR4 receptors have been identified on enteric neurons and LPS exposure causes neuronal loss, counteracted by vasoactive intestinal peptide (VIP), by unknown mechanisms. In addition AMP activated protein kinase (AMPK) stimulation causes loss of enteric neurons. This study investigated a possible role of AMPK activation in LPS-induced neuronal loss.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4912964
- author
- Voss, Ulrikke LU and Ekblad, Eva LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 9
- issue
- 12
- article number
- e114044
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:25462874
- wos:000345869700087
- scopus:84914665563
- pmid:25462874
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0114044
- language
- English
- LU publication?
- yes
- id
- 6d99603c-9b6f-401b-ad04-9421751bac3d (old id 4912964)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25462874?dopt=Abstract
- date added to LUP
- 2016-04-01 14:56:20
- date last changed
- 2022-01-28 03:15:30
@article{6d99603c-9b6f-401b-ad04-9421751bac3d, abstract = {{Intestinal barrier function is vital for homeostasis. Conditions where the mucosal barrier is compromised lead to increased plasma content of lipopolysaccharide (LPS). LPS acts on Toll-like receptor 4 (TLR4) and initiates cellular inflammatory responses. TLR4 receptors have been identified on enteric neurons and LPS exposure causes neuronal loss, counteracted by vasoactive intestinal peptide (VIP), by unknown mechanisms. In addition AMP activated protein kinase (AMPK) stimulation causes loss of enteric neurons. This study investigated a possible role of AMPK activation in LPS-induced neuronal loss.}}, author = {{Voss, Ulrikke and Ekblad, Eva}}, issn = {{1932-6203}}, language = {{eng}}, number = {{12}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{Lipopolysaccharide-Induced Loss of Cultured Rat Myenteric Neurons - Role of AMP-Activated Protein Kinase.}}, url = {{https://lup.lub.lu.se/search/files/4256733/7696630.pdf}}, doi = {{10.1371/journal.pone.0114044}}, volume = {{9}}, year = {{2014}}, }