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Antiobesity drugs in early pregnancy and congenital malformations in the offspring.

Källén, Bengt LU (2014) In Obesity Research and Clinical Practice 8(6). p.571-576
Abstract
Little information exists on the possible teratogenic effect of modern antiobesity drugs. The present study refers to orlistat, sibutramine, and rimonabant. Data in the Swedish Medical Birth Register were utilised. During the years 1998-2011, among 392,126 infants born, 509 had been exposed to antiobesity drugs in early pregnancy: 248 to orlistat, 242 to sibutramine, 12 to rimonabant, 13 to unspecified antiobesity drugs. Simultaneous use of orlistat and sibutramine occurred in six cases. No increase in major malformation risk was seen after orlistat (relative risk=0.42, 95% confidence interval 0.11-1.07) but a significantly high risk was seen after sibutramine (relative risk=1.81, 95% confidence interval 1.02-2.99). The latter effect,... (More)
Little information exists on the possible teratogenic effect of modern antiobesity drugs. The present study refers to orlistat, sibutramine, and rimonabant. Data in the Swedish Medical Birth Register were utilised. During the years 1998-2011, among 392,126 infants born, 509 had been exposed to antiobesity drugs in early pregnancy: 248 to orlistat, 242 to sibutramine, 12 to rimonabant, 13 to unspecified antiobesity drugs. Simultaneous use of orlistat and sibutramine occurred in six cases. No increase in major malformation risk was seen after orlistat (relative risk=0.42, 95% confidence interval 0.11-1.07) but a significantly high risk was seen after sibutramine (relative risk=1.81, 95% confidence interval 1.02-2.99). The latter effect, which seemed to be mainly due to an increased risk for a cardiovascular defects, may be related to the capacity of the drug to prolong QT-time. Sibutramine has been withdrawn in Europe but is still available on the Internet and is a component in some slimming preparations. Among the 12 infants exposed to rimonabant, two which were in a twin pair were malformed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Obesity Research and Clinical Practice
volume
8
issue
6
pages
571 - 576
publisher
Elsevier
external identifiers
  • pmid:25434912
  • wos:000345629600007
  • scopus:84920111757
ISSN
1878-0318
DOI
10.1016/j.orcp.2013.11.008
language
English
LU publication?
yes
id
5ddb43a3-7c28-431f-b158-c0580fc7a89b (old id 4913696)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25434912?dopt=Abstract
date added to LUP
2015-01-06 10:07:39
date last changed
2017-02-22 10:46:26
@article{5ddb43a3-7c28-431f-b158-c0580fc7a89b,
  abstract     = {Little information exists on the possible teratogenic effect of modern antiobesity drugs. The present study refers to orlistat, sibutramine, and rimonabant. Data in the Swedish Medical Birth Register were utilised. During the years 1998-2011, among 392,126 infants born, 509 had been exposed to antiobesity drugs in early pregnancy: 248 to orlistat, 242 to sibutramine, 12 to rimonabant, 13 to unspecified antiobesity drugs. Simultaneous use of orlistat and sibutramine occurred in six cases. No increase in major malformation risk was seen after orlistat (relative risk=0.42, 95% confidence interval 0.11-1.07) but a significantly high risk was seen after sibutramine (relative risk=1.81, 95% confidence interval 1.02-2.99). The latter effect, which seemed to be mainly due to an increased risk for a cardiovascular defects, may be related to the capacity of the drug to prolong QT-time. Sibutramine has been withdrawn in Europe but is still available on the Internet and is a component in some slimming preparations. Among the 12 infants exposed to rimonabant, two which were in a twin pair were malformed.},
  author       = {Källén, Bengt},
  issn         = {1878-0318},
  language     = {eng},
  number       = {6},
  pages        = {571--576},
  publisher    = {Elsevier},
  series       = {Obesity Research and Clinical Practice},
  title        = {Antiobesity drugs in early pregnancy and congenital malformations in the offspring.},
  url          = {http://dx.doi.org/10.1016/j.orcp.2013.11.008},
  volume       = {8},
  year         = {2014},
}