Permanent alterations induced in plasma prolactin and estrogen receptor concentration in benign and malignant tissue of women who started oral contraceptive use at an early age
(1987) In Anticancer research 7(4 B). p.853-856- Abstract
In 65 young women undergoing curettage for benign utrine disorders a signicicant relationship was found between early oral contraceptive use (starting age<25 years) and a high ratio of ln plasma prolactin versus ln estrogen receptor concentration of the uterine mucosae (p<0.047, Mann-Whitneys U-test). Year of birth, age at menarche, age at first full term pregnancy, parity, menstrual cycle phase and duration of oral contraceptive use could not explain the results. Because similar results have previously been found for breast cancer patients using plasma prolactin and breast tumour estrogen receptor concentration, the findings indicate that early oral contraceptive use permanently alters plasma prolactin levels and estrogen... (More)
In 65 young women undergoing curettage for benign utrine disorders a signicicant relationship was found between early oral contraceptive use (starting age<25 years) and a high ratio of ln plasma prolactin versus ln estrogen receptor concentration of the uterine mucosae (p<0.047, Mann-Whitneys U-test). Year of birth, age at menarche, age at first full term pregnancy, parity, menstrual cycle phase and duration of oral contraceptive use could not explain the results. Because similar results have previously been found for breast cancer patients using plasma prolactin and breast tumour estrogen receptor concentration, the findings indicate that early oral contraceptive use permanently alters plasma prolactin levels and estrogen receptor concentration, both in benign uterine tissue and in malignant breast tumours.
(Less)
- author
- Olsson, H. LU ; Lindahl, B. LU ; Ranstam, J. ; Borg, A. LU ; Ferno, M. LU and Norgren, A.
- organization
- publishing date
- 1987-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Anticancer research
- volume
- 7
- issue
- 4 B
- pages
- 853 - 856
- publisher
- International Institute of Cancer Research
- external identifiers
-
- pmid:3674773
- scopus:0023243127
- ISSN
- 0250-7005
- language
- English
- LU publication?
- yes
- id
- 491dc008-cc57-4624-a0af-8d82b0dc4784
- date added to LUP
- 2018-12-17 16:11:15
- date last changed
- 2024-01-15 10:04:42
@article{491dc008-cc57-4624-a0af-8d82b0dc4784, abstract = {{<p>In 65 young women undergoing curettage for benign utrine disorders a signicicant relationship was found between early oral contraceptive use (starting age<25 years) and a high ratio of ln plasma prolactin versus ln estrogen receptor concentration of the uterine mucosae (p<0.047, Mann-Whitneys U-test). Year of birth, age at menarche, age at first full term pregnancy, parity, menstrual cycle phase and duration of oral contraceptive use could not explain the results. Because similar results have previously been found for breast cancer patients using plasma prolactin and breast tumour estrogen receptor concentration, the findings indicate that early oral contraceptive use permanently alters plasma prolactin levels and estrogen receptor concentration, both in benign uterine tissue and in malignant breast tumours.</p>}}, author = {{Olsson, H. and Lindahl, B. and Ranstam, J. and Borg, A. and Ferno, M. and Norgren, A.}}, issn = {{0250-7005}}, language = {{eng}}, month = {{01}}, number = {{4 B}}, pages = {{853--856}}, publisher = {{International Institute of Cancer Research}}, series = {{Anticancer research}}, title = {{Permanent alterations induced in plasma prolactin and estrogen receptor concentration in benign and malignant tissue of women who started oral contraceptive use at an early age}}, volume = {{7}}, year = {{1987}}, }