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Permanent alterations induced in plasma prolactin and estrogen receptor concentration in benign and malignant tissue of women who started oral contraceptive use at an early age

Olsson, H. LU orcid ; Lindahl, B. LU ; Ranstam, J. ; Borg, A. LU ; Ferno, M. LU and Norgren, A. (1987) In Anticancer research 7(4 B). p.853-856
Abstract

In 65 young women undergoing curettage for benign utrine disorders a signicicant relationship was found between early oral contraceptive use (starting age<25 years) and a high ratio of ln plasma prolactin versus ln estrogen receptor concentration of the uterine mucosae (p<0.047, Mann-Whitneys U-test). Year of birth, age at menarche, age at first full term pregnancy, parity, menstrual cycle phase and duration of oral contraceptive use could not explain the results. Because similar results have previously been found for breast cancer patients using plasma prolactin and breast tumour estrogen receptor concentration, the findings indicate that early oral contraceptive use permanently alters plasma prolactin levels and estrogen... (More)

In 65 young women undergoing curettage for benign utrine disorders a signicicant relationship was found between early oral contraceptive use (starting age<25 years) and a high ratio of ln plasma prolactin versus ln estrogen receptor concentration of the uterine mucosae (p<0.047, Mann-Whitneys U-test). Year of birth, age at menarche, age at first full term pregnancy, parity, menstrual cycle phase and duration of oral contraceptive use could not explain the results. Because similar results have previously been found for breast cancer patients using plasma prolactin and breast tumour estrogen receptor concentration, the findings indicate that early oral contraceptive use permanently alters plasma prolactin levels and estrogen receptor concentration, both in benign uterine tissue and in malignant breast tumours.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Anticancer research
volume
7
issue
4 B
pages
853 - 856
publisher
International Institute of Cancer Research
external identifiers
  • pmid:3674773
  • scopus:0023243127
ISSN
0250-7005
language
English
LU publication?
yes
id
491dc008-cc57-4624-a0af-8d82b0dc4784
date added to LUP
2018-12-17 16:11:15
date last changed
2024-01-15 10:04:42
@article{491dc008-cc57-4624-a0af-8d82b0dc4784,
  abstract     = {{<p>In 65 young women undergoing curettage for benign utrine disorders a signicicant relationship was found between early oral contraceptive use (starting age&lt;25 years) and a high ratio of ln plasma prolactin versus ln estrogen receptor concentration of the uterine mucosae (p&lt;0.047, Mann-Whitneys U-test). Year of birth, age at menarche, age at first full term pregnancy, parity, menstrual cycle phase and duration of oral contraceptive use could not explain the results. Because similar results have previously been found for breast cancer patients using plasma prolactin and breast tumour estrogen receptor concentration, the findings indicate that early oral contraceptive use permanently alters plasma prolactin levels and estrogen receptor concentration, both in benign uterine tissue and in malignant breast tumours.</p>}},
  author       = {{Olsson, H. and Lindahl, B. and Ranstam, J. and Borg, A. and Ferno, M. and Norgren, A.}},
  issn         = {{0250-7005}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{4 B}},
  pages        = {{853--856}},
  publisher    = {{International Institute of Cancer Research}},
  series       = {{Anticancer research}},
  title        = {{Permanent alterations induced in plasma prolactin and estrogen receptor concentration in benign and malignant tissue of women who started oral contraceptive use at an early age}},
  volume       = {{7}},
  year         = {{1987}},
}