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Perchloroethylene: Effects on body and organ weights and plasma buturylcholinesterase activity in mice

Kjellstrand, P.; Holmquist, Björn LU ; Kanje, Martin LU ; Alm, Per LU ; Romare, Sören; Jonsson, I; Månsson, Lennart and Bjerkemo, M (1984) In Acta Pharmacologica et Toxicologica 54(5). p.414-424
Abstract
The effects of continuous and intermittent inhalation of perchloroethylene (PCE) on plasma butyrylcholinesterase (BuChE) activity, organ weights, liver morphology and motor activity in mice (strain NMRI) were tested. PCE exposure increased plasma BuChE activity in a time- and concentration dependent manner in both sexes. The increase was statistically significant at 37 p.p.m. in animals continuously exposed for 30 days. BuChE increased approximately 1.5 times in females and 2.5 times in males after 120 days exposure to 150 p.p.m. After rehabilitation of animals exposed for 30 days to 150 p.p.m., BuChE levels returned to normal. Liver weight also increased in a time and concentration dependent manner. Both sexes exhibited significant liver... (More)
The effects of continuous and intermittent inhalation of perchloroethylene (PCE) on plasma butyrylcholinesterase (BuChE) activity, organ weights, liver morphology and motor activity in mice (strain NMRI) were tested. PCE exposure increased plasma BuChE activity in a time- and concentration dependent manner in both sexes. The increase was statistically significant at 37 p.p.m. in animals continuously exposed for 30 days. BuChE increased approximately 1.5 times in females and 2.5 times in males after 120 days exposure to 150 p.p.m. After rehabilitation of animals exposed for 30 days to 150 p.p.m., BuChE levels returned to normal. Liver weight also increased in a time and concentration dependent manner. Both sexes exhibited significant liver enlargement at 9 p.p.m. The increase was about 2.3 in females and 1.9 in males after continuous exposure to 150 p.p.m. for 120 days. After rehabilitation (120 days) of animals exposed to 150 p.p.m. for 30 days, a 10% increase still remained. A decrease in body weight gain was seen in both sexes after exposure to concentrations above 75 p.p.m. Female kidney weight was slightly increased. No clear effect on spleen weight could be detected. When the same time-weighted average concentration was used, intermittent exposure for 30 days had similar effects on liver weight and BuChE activity as continuous exposure, even when exposures lasted for only one hour per day. Liver cell morphology was changed after PCE exposure. The alterations could be observed already at 9 p.p.m. but disappeared after rehabilitation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Body weight, butyrylcholinesterase activity, kidney liver, mice, motor activity, perchloroethylene, plasma, spleen
in
Acta Pharmacologica et Toxicologica
volume
54
issue
5
pages
414 - 424
publisher
Nordic Pharmacological Society
external identifiers
  • scopus:0021258320
ISSN
0001-6683
DOI
10.1111/j.1600-0773.1984.tb01951.x
language
English
LU publication?
yes
id
c8b5d9f6-95dd-494c-a225-22d11e62f4f6 (old id 4934161)
date added to LUP
2015-01-20 16:51:23
date last changed
2017-03-19 04:09:22
@article{c8b5d9f6-95dd-494c-a225-22d11e62f4f6,
  abstract     = {The effects of continuous and intermittent inhalation of perchloroethylene (PCE) on plasma butyrylcholinesterase (BuChE) activity, organ weights, liver morphology and motor activity in mice (strain NMRI) were tested. PCE exposure increased plasma BuChE activity in a time- and concentration dependent manner in both sexes. The increase was statistically significant at 37 p.p.m. in animals continuously exposed for 30 days. BuChE increased approximately 1.5 times in females and 2.5 times in males after 120 days exposure to 150 p.p.m. After rehabilitation of animals exposed for 30 days to 150 p.p.m., BuChE levels returned to normal. Liver weight also increased in a time and concentration dependent manner. Both sexes exhibited significant liver enlargement at 9 p.p.m. The increase was about 2.3 in females and 1.9 in males after continuous exposure to 150 p.p.m. for 120 days. After rehabilitation (120 days) of animals exposed to 150 p.p.m. for 30 days, a 10% increase still remained. A decrease in body weight gain was seen in both sexes after exposure to concentrations above 75 p.p.m. Female kidney weight was slightly increased. No clear effect on spleen weight could be detected. When the same time-weighted average concentration was used, intermittent exposure for 30 days had similar effects on liver weight and BuChE activity as continuous exposure, even when exposures lasted for only one hour per day. Liver cell morphology was changed after PCE exposure. The alterations could be observed already at 9 p.p.m. but disappeared after rehabilitation.},
  author       = {Kjellstrand, P. and Holmquist, Björn and Kanje, Martin and Alm, Per and Romare, Sören and Jonsson, I and Månsson, Lennart and Bjerkemo, M},
  issn         = {0001-6683},
  keyword      = {Body weight,butyrylcholinesterase activity,kidney liver,mice,motor activity,perchloroethylene,plasma,spleen},
  language     = {eng},
  number       = {5},
  pages        = {414--424},
  publisher    = {Nordic Pharmacological Society},
  series       = {Acta Pharmacologica et Toxicologica},
  title        = {Perchloroethylene: Effects on body and organ weights and plasma buturylcholinesterase activity in mice},
  url          = {http://dx.doi.org/10.1111/j.1600-0773.1984.tb01951.x},
  volume       = {54},
  year         = {1984},
}