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Pitfalls in the interpretation of long-term inhalation experiments

Kjellstrand, Per and Holmquist, Björn LU (1984) In Toxicology Letters 21(2). p.213-218
Abstract
Age- and weight-matched groups of mice were enclosed in airtight chambers and exposed to clean, filtered air for 1 month. At the end of the exposure period, body, liver and spleen weights and plasma butyrylcholinesterase (BuChE) activity were measured. More than twice as many significant differences in these parameters occurred compared with the expected results if only random differences existed between the groups. Thus, isolation of animal groups for extended periods of time in inhalation experiments alone may lead to differences in various biological parameters. When testing the effects of unknown substances such differences may be mistaken for reactions to the test agent, which actually may have no effect.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Body weight, exposure, inhalation, kidney, liver, mouse, spleen
in
Toxicology Letters
volume
21
issue
2
pages
213 - 218
publisher
Elsevier
external identifiers
  • scopus:0021239661
ISSN
1879-3169
DOI
10.1016/0378-4274(84)90209-1
language
English
LU publication?
yes
id
fc1936e5-041b-4c5a-9a78-7963debb822e (old id 4934172)
date added to LUP
2015-01-21 10:47:48
date last changed
2017-01-01 06:45:44
@article{fc1936e5-041b-4c5a-9a78-7963debb822e,
  abstract     = {Age- and weight-matched groups of mice were enclosed in airtight chambers and exposed to clean, filtered air for 1 month. At the end of the exposure period, body, liver and spleen weights and plasma butyrylcholinesterase (BuChE) activity were measured. More than twice as many significant differences in these parameters occurred compared with the expected results if only random differences existed between the groups. Thus, isolation of animal groups for extended periods of time in inhalation experiments alone may lead to differences in various biological parameters. When testing the effects of unknown substances such differences may be mistaken for reactions to the test agent, which actually may have no effect.},
  author       = {Kjellstrand, Per and Holmquist, Björn},
  issn         = {1879-3169},
  keyword      = {Body weight,exposure,inhalation,kidney,liver,mouse,spleen},
  language     = {eng},
  number       = {2},
  pages        = {213--218},
  publisher    = {Elsevier},
  series       = {Toxicology Letters},
  title        = {Pitfalls in the interpretation of long-term inhalation experiments},
  url          = {http://dx.doi.org/10.1016/0378-4274(84)90209-1},
  volume       = {21},
  year         = {1984},
}