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Effects of continuous Trichloroethylene inhalation on different strains of mice

Kjellstrand, Per; Holmquist, Björn LU ; Mandahl, Nils LU and Bjerkemo, M (1983) In Acta Pharmacologica et Toxicologica 53(5). p.369-374
Abstract
Seven different strains of mice (wild, C57BL, DBA, B6CBA, A/sn, NZB and NMRI) were continuously exposed to 150 ppm trichloroethylene (TCE) during 30 days. After exposure all strains showed large increases in liver weight, while changes in kidney and spleen weights were small. Plasma butyrylcholinesterase (BuChE) activity increased in males of all strains and in females of strains A/sn and NZB. The increase in the females was less than that of the corresponding males. We concluded that there are moderate, but in some cases, significant differences in TCE sensitivity between different mouse strains. The differences observed between sexes emphasizes the importance of specifying sex as well as strain when reporting on toxic effects.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
liver, trichloroethylene, mice, mouse strain, spleen, kidney, esterase, inhalation, Body weight- butyrylcholin
in
Acta Pharmacologica et Toxicologica
volume
53
issue
5
pages
369 - 374
publisher
Nordic Pharmacological Society
external identifiers
  • scopus:0021059538
ISSN
0001-6683
DOI
10.1111/j.1600-0773.1983.tb03437.x
language
English
LU publication?
yes
id
2a381d27-3a5e-4bcb-87d3-603d2da4939a (old id 4934705)
date added to LUP
2015-01-21 11:24:51
date last changed
2017-01-01 07:05:27
@article{2a381d27-3a5e-4bcb-87d3-603d2da4939a,
  abstract     = {Seven different strains of mice (wild, C57BL, DBA, B6CBA, A/sn, NZB and NMRI) were continuously exposed to 150 ppm trichloroethylene (TCE) during 30 days. After exposure all strains showed large increases in liver weight, while changes in kidney and spleen weights were small. Plasma butyrylcholinesterase (BuChE) activity increased in males of all strains and in females of strains A/sn and NZB. The increase in the females was less than that of the corresponding males. We concluded that there are moderate, but in some cases, significant differences in TCE sensitivity between different mouse strains. The differences observed between sexes emphasizes the importance of specifying sex as well as strain when reporting on toxic effects.},
  author       = {Kjellstrand, Per and Holmquist, Björn and Mandahl, Nils and Bjerkemo, M},
  issn         = {0001-6683},
  keyword      = {liver,trichloroethylene,mice,mouse strain,spleen,kidney,esterase,inhalation,Body weight- butyrylcholin},
  language     = {eng},
  number       = {5},
  pages        = {369--374},
  publisher    = {Nordic Pharmacological Society},
  series       = {Acta Pharmacologica et Toxicologica},
  title        = {Effects of continuous Trichloroethylene inhalation on different strains of mice},
  url          = {http://dx.doi.org/10.1111/j.1600-0773.1983.tb03437.x},
  volume       = {53},
  year         = {1983},
}