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Trichloroethylene: Effects on body and organ weights in mice, rats and gerbils

Kjellstrand, Per; Kanje, Martin LU ; Månsson, Lennart; Bjerkemo, M; Mortensen, I; Lanke, Jan LU and Holmquist, Björn LU (1981) In Toxicology 21(2). p.105-115
Abstract
The influence of continuous inhalation of 150 ppm trichloroethylene (TCE) on body, liver, spleen, and kidney weights in rats, mice, and mongolian gerbils was tested.



An age dependent decrease in body weight gain was observed in female rats exposed to TCE. All 3 spcies showed liver enlargement caused by the exposure. The effect was much more pronounced in mice, in which the increase was 60–80%, than in rats and gerbils where it was only 20–30%. After the end of the TCE-exposure the liver weights of the mice decreased rapidly. After 5 days of rehabilitation to the weight was only 10–20% higher than that of the controls. This difference persisted for at least 25 days. The spleen weight appeared unaffected or somewhat... (More)
The influence of continuous inhalation of 150 ppm trichloroethylene (TCE) on body, liver, spleen, and kidney weights in rats, mice, and mongolian gerbils was tested.



An age dependent decrease in body weight gain was observed in female rats exposed to TCE. All 3 spcies showed liver enlargement caused by the exposure. The effect was much more pronounced in mice, in which the increase was 60–80%, than in rats and gerbils where it was only 20–30%. After the end of the TCE-exposure the liver weights of the mice decreased rapidly. After 5 days of rehabilitation to the weight was only 10–20% higher than that of the controls. This difference persisted for at least 25 days. The spleen weight appeared unaffected or somewhat smaller in TCE-exposed animals of all species. An increased kidney weight (15%) was observed in TCE-exposed gerbils. This effect was less pronounced in mice and rats.



Effects on the liver have earlier been seen only after exposure to concentrations much higher than that used in the present study. This difference is results in proposed to be due to the different schedules used for the exposure. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Toxicology
volume
21
issue
2
pages
105 - 115
publisher
Elsevier
external identifiers
  • scopus:0019459262
ISSN
0300-483X
DOI
10.1016/0300-483X(81)90121-9
language
English
LU publication?
yes
id
81af1afc-5b4b-4cee-ba53-9e99bfdee76f (old id 4934766)
date added to LUP
2015-01-21 11:18:56
date last changed
2017-08-20 04:34:20
@article{81af1afc-5b4b-4cee-ba53-9e99bfdee76f,
  abstract     = {The influence of continuous inhalation of 150 ppm trichloroethylene (TCE) on body, liver, spleen, and kidney weights in rats, mice, and mongolian gerbils was tested.<br/><br>
<br/><br>
An age dependent decrease in body weight gain was observed in female rats exposed to TCE. All 3 spcies showed liver enlargement caused by the exposure. The effect was much more pronounced in mice, in which the increase was 60–80%, than in rats and gerbils where it was only 20–30%. After the end of the TCE-exposure the liver weights of the mice decreased rapidly. After 5 days of rehabilitation to the weight was only 10–20% higher than that of the controls. This difference persisted for at least 25 days. The spleen weight appeared unaffected or somewhat smaller in TCE-exposed animals of all species. An increased kidney weight (15%) was observed in TCE-exposed gerbils. This effect was less pronounced in mice and rats.<br/><br>
<br/><br>
Effects on the liver have earlier been seen only after exposure to concentrations much higher than that used in the present study. This difference is results in proposed to be due to the different schedules used for the exposure.},
  author       = {Kjellstrand, Per and Kanje, Martin and Månsson, Lennart and Bjerkemo, M and Mortensen, I and Lanke, Jan and Holmquist, Björn},
  issn         = {0300-483X},
  language     = {eng},
  number       = {2},
  pages        = {105--115},
  publisher    = {Elsevier},
  series       = {Toxicology},
  title        = {Trichloroethylene: Effects on body and organ weights in mice, rats and gerbils},
  url          = {http://dx.doi.org/10.1016/0300-483X(81)90121-9},
  volume       = {21},
  year         = {1981},
}