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Endocrine aspects and sequel in patients with craniopharyngioma

Erfurth, Eva Marie LU (2015) In Journal of Pediatric Endocrinology & Metabolism 28(1-2). p.19-26
Abstract
A craniopharyngioma (CP) is an embryonic malformation of the sellar and parasellar region. The annual incidence is 0.5-2.0 cases/million per year and approximately 60% of CP is seen in adulthood. The therapy of choice is surgery, followed by cranial radiotherapy in about half of the patients. Typical initial manifestations at diagnosis in children are symptoms of elevated intracranial pressure, visual disturbances and hypopituitarism. CPs have the highest mortality of all pituitary tumours. The standardised overall mortality rate varies from 2.88 to 9.28 in cohort studies. Adults with CP have a 3-19-fold higher cardiovascular mortality in comparison to the general population. Women with CP have an even higher risk. The long-term morbidity... (More)
A craniopharyngioma (CP) is an embryonic malformation of the sellar and parasellar region. The annual incidence is 0.5-2.0 cases/million per year and approximately 60% of CP is seen in adulthood. The therapy of choice is surgery, followed by cranial radiotherapy in about half of the patients. Typical initial manifestations at diagnosis in children are symptoms of elevated intracranial pressure, visual disturbances and hypopituitarism. CPs have the highest mortality of all pituitary tumours. The standardised overall mortality rate varies from 2.88 to 9.28 in cohort studies. Adults with CP have a 3-19-fold higher cardiovascular mortality in comparison to the general population. Women with CP have an even higher risk. The long-term morbidity is substantial with hypopituitarism, increased cardiovascular risk, hypothalamic damage, visual and neurological deficits, reduced bone health and reduction in quality of life and cognitive function. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cardiovascular risk, cognitive function, hypopituitarism, hypothalamic, damage, morbidity, mortality, quality of life
in
Journal of Pediatric Endocrinology & Metabolism
volume
28
issue
1-2
pages
19 - 26
publisher
Freund Publishing House Ltd
external identifiers
  • wos:000346764500004
  • scopus:84920099137
ISSN
2191-0251
DOI
10.1515/jpem-2014-0419
language
English
LU publication?
yes
id
3279633a-632e-45af-afcc-287e4368ddbb (old id 4941337)
date added to LUP
2015-02-03 07:16:52
date last changed
2017-11-19 03:08:04
@article{3279633a-632e-45af-afcc-287e4368ddbb,
  abstract     = {A craniopharyngioma (CP) is an embryonic malformation of the sellar and parasellar region. The annual incidence is 0.5-2.0 cases/million per year and approximately 60% of CP is seen in adulthood. The therapy of choice is surgery, followed by cranial radiotherapy in about half of the patients. Typical initial manifestations at diagnosis in children are symptoms of elevated intracranial pressure, visual disturbances and hypopituitarism. CPs have the highest mortality of all pituitary tumours. The standardised overall mortality rate varies from 2.88 to 9.28 in cohort studies. Adults with CP have a 3-19-fold higher cardiovascular mortality in comparison to the general population. Women with CP have an even higher risk. The long-term morbidity is substantial with hypopituitarism, increased cardiovascular risk, hypothalamic damage, visual and neurological deficits, reduced bone health and reduction in quality of life and cognitive function.},
  author       = {Erfurth, Eva Marie},
  issn         = {2191-0251},
  keyword      = {cardiovascular risk,cognitive function,hypopituitarism,hypothalamic,damage,morbidity,mortality,quality of life},
  language     = {eng},
  number       = {1-2},
  pages        = {19--26},
  publisher    = {Freund Publishing House Ltd},
  series       = {Journal of Pediatric Endocrinology & Metabolism},
  title        = {Endocrine aspects and sequel in patients with craniopharyngioma},
  url          = {http://dx.doi.org/10.1515/jpem-2014-0419},
  volume       = {28},
  year         = {2015},
}