Endocrine aspects and sequel in patients with craniopharyngioma
(2015) In Journal of Pediatric Endocrinology & Metabolism 28(1-2). p.19-26- Abstract
- A craniopharyngioma (CP) is an embryonic malformation of the sellar and parasellar region. The annual incidence is 0.5-2.0 cases/million per year and approximately 60% of CP is seen in adulthood. The therapy of choice is surgery, followed by cranial radiotherapy in about half of the patients. Typical initial manifestations at diagnosis in children are symptoms of elevated intracranial pressure, visual disturbances and hypopituitarism. CPs have the highest mortality of all pituitary tumours. The standardised overall mortality rate varies from 2.88 to 9.28 in cohort studies. Adults with CP have a 3-19-fold higher cardiovascular mortality in comparison to the general population. Women with CP have an even higher risk. The long-term morbidity... (More)
- A craniopharyngioma (CP) is an embryonic malformation of the sellar and parasellar region. The annual incidence is 0.5-2.0 cases/million per year and approximately 60% of CP is seen in adulthood. The therapy of choice is surgery, followed by cranial radiotherapy in about half of the patients. Typical initial manifestations at diagnosis in children are symptoms of elevated intracranial pressure, visual disturbances and hypopituitarism. CPs have the highest mortality of all pituitary tumours. The standardised overall mortality rate varies from 2.88 to 9.28 in cohort studies. Adults with CP have a 3-19-fold higher cardiovascular mortality in comparison to the general population. Women with CP have an even higher risk. The long-term morbidity is substantial with hypopituitarism, increased cardiovascular risk, hypothalamic damage, visual and neurological deficits, reduced bone health and reduction in quality of life and cognitive function. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4941337
- author
- Erfurth, Eva Marie LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cardiovascular risk, cognitive function, hypopituitarism, hypothalamic, damage, morbidity, mortality, quality of life
- in
- Journal of Pediatric Endocrinology & Metabolism
- volume
- 28
- issue
- 1-2
- pages
- 19 - 26
- publisher
- Freund Publishing House Ltd
- external identifiers
-
- wos:000346764500004
- scopus:84920099137
- pmid:25514328
- ISSN
- 2191-0251
- DOI
- 10.1515/jpem-2014-0419
- language
- English
- LU publication?
- yes
- id
- 3279633a-632e-45af-afcc-287e4368ddbb (old id 4941337)
- date added to LUP
- 2016-04-01 10:14:49
- date last changed
- 2024-11-04 02:33:09
@article{3279633a-632e-45af-afcc-287e4368ddbb,
abstract = {{A craniopharyngioma (CP) is an embryonic malformation of the sellar and parasellar region. The annual incidence is 0.5-2.0 cases/million per year and approximately 60% of CP is seen in adulthood. The therapy of choice is surgery, followed by cranial radiotherapy in about half of the patients. Typical initial manifestations at diagnosis in children are symptoms of elevated intracranial pressure, visual disturbances and hypopituitarism. CPs have the highest mortality of all pituitary tumours. The standardised overall mortality rate varies from 2.88 to 9.28 in cohort studies. Adults with CP have a 3-19-fold higher cardiovascular mortality in comparison to the general population. Women with CP have an even higher risk. The long-term morbidity is substantial with hypopituitarism, increased cardiovascular risk, hypothalamic damage, visual and neurological deficits, reduced bone health and reduction in quality of life and cognitive function.}},
author = {{Erfurth, Eva Marie}},
issn = {{2191-0251}},
keywords = {{cardiovascular risk; cognitive function; hypopituitarism; hypothalamic; damage; morbidity; mortality; quality of life}},
language = {{eng}},
number = {{1-2}},
pages = {{19--26}},
publisher = {{Freund Publishing House Ltd}},
series = {{Journal of Pediatric Endocrinology & Metabolism}},
title = {{Endocrine aspects and sequel in patients with craniopharyngioma}},
url = {{https://lup.lub.lu.se/search/files/1686827/7617052.pdf}},
doi = {{10.1515/jpem-2014-0419}},
volume = {{28}},
year = {{2015}},
}