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Cord blood insulinoma-associated protein 2 autoantibodies are associated with increased risk of type 1 diabetes in the population-based Diabetes Prediction in Skane study

Lundgren, Markus LU ; Lynch, Kristian; Larsson, Christer LU ; Elding Larsson, Helena LU ; , and Carlsson, Annelie LU (2015) In Diabetologia 58(1). p.75-78
Abstract
Aims/hypothesis The aim of this study was to examine the effect of cord blood autoantibodies on the risk for type 1 diabetes in children followed prospectively from birth. Methods The Diabetes Prediction in Skane (DiPiS) study consists of 35,853 children from the general population born during 2000-2004. Samples were collected at birth and analysed for HLA genotypes and autoantibodies to glutamate decarboxylase 65 (GAD65), insulin and insulinoma-associated protein 2 (IA-2). After adjusting for HLA, sex, maternal age and parental type 1 diabetes, independent associations with risk of diabetes were assessed using multivariate Cox proportional hazards models. Results In total, 151 children (0.4%) had developed type 1 diabetes by the end of... (More)
Aims/hypothesis The aim of this study was to examine the effect of cord blood autoantibodies on the risk for type 1 diabetes in children followed prospectively from birth. Methods The Diabetes Prediction in Skane (DiPiS) study consists of 35,853 children from the general population born during 2000-2004. Samples were collected at birth and analysed for HLA genotypes and autoantibodies to glutamate decarboxylase 65 (GAD65), insulin and insulinoma-associated protein 2 (IA-2). After adjusting for HLA, sex, maternal age and parental type 1 diabetes, independent associations with risk of diabetes were assessed using multivariate Cox proportional hazards models. Results In total, 151 children (0.4%) had developed type 1 diabetes by the end of 2013 at a median age of 5.8 years (0.8-12.2 years). In the multivariate analysis, the presence of IA-2 autoantibodies (IA-2A) in cord blood (HR 6.88, 95% CI 1.46,32.4; p = 0.003), but not maternal diabetes (HR 1.38, 95% CI 0.24,7.84; p = 0.71), was associated with risk of developing type 1 diabetes. No increased risk could be seen for the presence of autoantibodies to GAD65 or insulin. Conclusions/interpretation Our study indicates that the presence of cord blood IA-2A superimposes maternal diabetes and other cord blood islet autoantibodies as a predictor of type 1 diabetes development in the child. These findings may be of significance for future screening and study protocols on type 1 diabetes prediction. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
GAD65 autoantibodies, IA-2 autoantibodies, Insulin autoantibodies, Paediatric, Prediction, Type 1 diabetes
in
Diabetologia
volume
58
issue
1
pages
75 - 78
publisher
Springer Verlag
external identifiers
  • wos:000346022300012
  • scopus:84916597779
ISSN
1432-0428
DOI
10.1007/s00125-014-3394-6
language
English
LU publication?
yes
id
e6f2ba87-ef25-4d01-87bc-7059acaff48a (old id 4950724)
date added to LUP
2015-02-03 07:05:04
date last changed
2017-11-12 03:01:33
@article{e6f2ba87-ef25-4d01-87bc-7059acaff48a,
  abstract     = {Aims/hypothesis The aim of this study was to examine the effect of cord blood autoantibodies on the risk for type 1 diabetes in children followed prospectively from birth. Methods The Diabetes Prediction in Skane (DiPiS) study consists of 35,853 children from the general population born during 2000-2004. Samples were collected at birth and analysed for HLA genotypes and autoantibodies to glutamate decarboxylase 65 (GAD65), insulin and insulinoma-associated protein 2 (IA-2). After adjusting for HLA, sex, maternal age and parental type 1 diabetes, independent associations with risk of diabetes were assessed using multivariate Cox proportional hazards models. Results In total, 151 children (0.4%) had developed type 1 diabetes by the end of 2013 at a median age of 5.8 years (0.8-12.2 years). In the multivariate analysis, the presence of IA-2 autoantibodies (IA-2A) in cord blood (HR 6.88, 95% CI 1.46,32.4; p = 0.003), but not maternal diabetes (HR 1.38, 95% CI 0.24,7.84; p = 0.71), was associated with risk of developing type 1 diabetes. No increased risk could be seen for the presence of autoantibodies to GAD65 or insulin. Conclusions/interpretation Our study indicates that the presence of cord blood IA-2A superimposes maternal diabetes and other cord blood islet autoantibodies as a predictor of type 1 diabetes development in the child. These findings may be of significance for future screening and study protocols on type 1 diabetes prediction.},
  author       = {Lundgren, Markus and Lynch, Kristian and Larsson, Christer and Elding Larsson, Helena and ,  and Carlsson, Annelie},
  issn         = {1432-0428},
  keyword      = {GAD65 autoantibodies,IA-2 autoantibodies,Insulin autoantibodies,Paediatric,Prediction,Type 1 diabetes},
  language     = {eng},
  number       = {1},
  pages        = {75--78},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Cord blood insulinoma-associated protein 2 autoantibodies are associated with increased risk of type 1 diabetes in the population-based Diabetes Prediction in Skane study},
  url          = {http://dx.doi.org/10.1007/s00125-014-3394-6},
  volume       = {58},
  year         = {2015},
}