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Molecular architectures of glycosylated dendronized bottle brushes in action : Biocompatibility and anti-amyloidogenic activity of pseudo-glycodendrimers

Kösterke, Tom ; Thakore, Radika LU ; Moreno, Silvia ; Pedersen, Jan Skov ; Voit, Brigitte ; Klementieva, Oxana LU orcid and Appelhans, Dietmar (2025) In Materials Today Bio 32.
Abstract

Glycopolymers are versatile materials for biomedical and healthcare applications, e.g., as carrier and polymeric therapeutics. Especially, the topology and surface composition of such materials play a key role in being promising materials in the anti-amyloidogenic interventions. Herein, 2nd and 3rd generation of pseudo-glycodendrimers (PGDs), based on hyperbranched polyester core with different sugar decorations, are synthesized, characterized, and used to investigate their anti-amyloidogenic properties toward Aβ (1–40) and (1–42), key players in Alzheimerś disease. The findings reveal that PGDs have a dendronized bottle brush architecture, as determined by SAXS analysis. PGDs are capable of interfering with the aggregation process of... (More)

Glycopolymers are versatile materials for biomedical and healthcare applications, e.g., as carrier and polymeric therapeutics. Especially, the topology and surface composition of such materials play a key role in being promising materials in the anti-amyloidogenic interventions. Herein, 2nd and 3rd generation of pseudo-glycodendrimers (PGDs), based on hyperbranched polyester core with different sugar decorations, are synthesized, characterized, and used to investigate their anti-amyloidogenic properties toward Aβ (1–40) and (1–42), key players in Alzheimerś disease. The findings reveal that PGDs have a dendronized bottle brush architecture, as determined by SAXS analysis. PGDs are capable of interfering with the aggregation process of Amyloid-β peptides due to the high degree of sugar functionalization on the outer surface and the specific molecular shape. Additionally, cell viability studies indicate that PGDs exhibit concentration-dependent biocompatibility. Importantly, it is demonstrated that PGDs can be multi-functionalized by various sugar molecules, dyes, and/or peptides in a final one-pot approach. These findings suggest that PGDs may offer new avenues for therapeutic research in neurodegenerative diseases. Finally, it should be noted that this kind of highly branched glycopolymers possesses a molecular shape of dendronized bottle brushes and not a globular perfectly branched structure like glycodendrimers, as originally postulated.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anti-amyloidogenic agent, Biocompatibility, Dendronized bottle brushes, Post-modification, Pseudo-glycodendrimers
in
Materials Today Bio
volume
32
article number
101771
publisher
Elsevier
external identifiers
  • scopus:105005257658
  • pmid:40496726
ISSN
2590-0064
DOI
10.1016/j.mtbio.2025.101771
language
English
LU publication?
yes
id
496545ec-0542-469c-9894-1e5cdbfe822b
date added to LUP
2025-08-01 09:54:54
date last changed
2025-08-15 11:08:22
@article{496545ec-0542-469c-9894-1e5cdbfe822b,
  abstract     = {{<p>Glycopolymers are versatile materials for biomedical and healthcare applications, e.g., as carrier and polymeric therapeutics. Especially, the topology and surface composition of such materials play a key role in being promising materials in the anti-amyloidogenic interventions. Herein, 2nd and 3rd generation of pseudo-glycodendrimers (PGDs), based on hyperbranched polyester core with different sugar decorations, are synthesized, characterized, and used to investigate their anti-amyloidogenic properties toward Aβ (1–40) and (1–42), key players in Alzheimerś disease. The findings reveal that PGDs have a dendronized bottle brush architecture, as determined by SAXS analysis. PGDs are capable of interfering with the aggregation process of Amyloid-β peptides due to the high degree of sugar functionalization on the outer surface and the specific molecular shape. Additionally, cell viability studies indicate that PGDs exhibit concentration-dependent biocompatibility. Importantly, it is demonstrated that PGDs can be multi-functionalized by various sugar molecules, dyes, and/or peptides in a final one-pot approach. These findings suggest that PGDs may offer new avenues for therapeutic research in neurodegenerative diseases. Finally, it should be noted that this kind of highly branched glycopolymers possesses a molecular shape of dendronized bottle brushes and not a globular perfectly branched structure like glycodendrimers, as originally postulated.</p>}},
  author       = {{Kösterke, Tom and Thakore, Radika and Moreno, Silvia and Pedersen, Jan Skov and Voit, Brigitte and Klementieva, Oxana and Appelhans, Dietmar}},
  issn         = {{2590-0064}},
  keywords     = {{Anti-amyloidogenic agent; Biocompatibility; Dendronized bottle brushes; Post-modification; Pseudo-glycodendrimers}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Materials Today Bio}},
  title        = {{Molecular architectures of glycosylated dendronized bottle brushes in action : Biocompatibility and anti-amyloidogenic activity of pseudo-glycodendrimers}},
  url          = {{http://dx.doi.org/10.1016/j.mtbio.2025.101771}},
  doi          = {{10.1016/j.mtbio.2025.101771}},
  volume       = {{32}},
  year         = {{2025}},
}