Higher levels of serum zonulin may rather be associated with increased risk of obesity and hyperlipidemia, than wih gastrointestinal symptoms or disease manifestaiton
(2017) In International Journal of Molecular Sciences 18(3).- Abstract
- Zonulin is considered a biomarker of increased intestinal permeability, and elevated levels have been found in celiac disease. The primary aim of this study was to examine the association between serum zonulin levels and gastrointestinal (GI) symptoms, and secondarily, between zonulin levels and anthropometric and metabolic factors. The offspring (n = 363) of the participants of the Malmö Diet and Cancer cardiovascular cohort (MDC-CV) were invited to an anthropometric and clinical examination, where fasting plasma glucose levels were measured. Questionnaires about lifestyle factors and medical history were completed along with the Visual Analog Scale for Irritable Bowel Syndrome (VAS-IBS). Zonulin levels were measured in serum by ELISA.... (More)
- Zonulin is considered a biomarker of increased intestinal permeability, and elevated levels have been found in celiac disease. The primary aim of this study was to examine the association between serum zonulin levels and gastrointestinal (GI) symptoms, and secondarily, between zonulin levels and anthropometric and metabolic factors. The offspring (n = 363) of the participants of the Malmö Diet and Cancer cardiovascular cohort (MDC-CV) were invited to an anthropometric and clinical examination, where fasting plasma glucose levels were measured. Questionnaires about lifestyle factors and medical history were completed along with the Visual Analog Scale for Irritable Bowel Syndrome (VAS-IBS). Zonulin levels were measured in serum by ELISA. Neither GI symptoms nor GI diseases had any influence on zonulin levels. Higher zonulin levels were associated with higher waist circumference (p = 0.003), diastolic blood pressure (p = 0.003), and glucose levels (p = 0.036). Higher zonulin levels were associated with increased risk of overweight (p < 0.001), obesity (p = 0.047), and hyperlipidemia (p = 0.048). We cannot detect altered zonulin levels among individuals reporting GI symptoms or GI diseases, but higher zonulin levels are associated with higher waist circumference, diastolic blood pressure, fasting glucose, and increased risk of metabolic diseases. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/49798db1-de5b-45fb-9284-b0427be67873
- author
- Ohlsson, Bodil LU ; Orho-Melander, Marju LU and Nilsson, Peter LU
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Molecular Sciences
- volume
- 18
- issue
- 3
- publisher
- MDPI AG
- external identifiers
-
- scopus:85014830587
- ISSN
- 1422-0067
- DOI
- 10.3390/ijms18030582
- language
- English
- LU publication?
- yes
- id
- 49798db1-de5b-45fb-9284-b0427be67873
- date added to LUP
- 2019-06-17 12:15:49
- date last changed
- 2022-04-26 01:45:51
@article{49798db1-de5b-45fb-9284-b0427be67873, abstract = {{Zonulin is considered a biomarker of increased intestinal permeability, and elevated levels have been found in celiac disease. The primary aim of this study was to examine the association between serum zonulin levels and gastrointestinal (GI) symptoms, and secondarily, between zonulin levels and anthropometric and metabolic factors. The offspring (n = 363) of the participants of the Malmö Diet and Cancer cardiovascular cohort (MDC-CV) were invited to an anthropometric and clinical examination, where fasting plasma glucose levels were measured. Questionnaires about lifestyle factors and medical history were completed along with the Visual Analog Scale for Irritable Bowel Syndrome (VAS-IBS). Zonulin levels were measured in serum by ELISA. Neither GI symptoms nor GI diseases had any influence on zonulin levels. Higher zonulin levels were associated with higher waist circumference (p = 0.003), diastolic blood pressure (p = 0.003), and glucose levels (p = 0.036). Higher zonulin levels were associated with increased risk of overweight (p < 0.001), obesity (p = 0.047), and hyperlipidemia (p = 0.048). We cannot detect altered zonulin levels among individuals reporting GI symptoms or GI diseases, but higher zonulin levels are associated with higher waist circumference, diastolic blood pressure, fasting glucose, and increased risk of metabolic diseases.}}, author = {{Ohlsson, Bodil and Orho-Melander, Marju and Nilsson, Peter}}, issn = {{1422-0067}}, language = {{eng}}, number = {{3}}, publisher = {{MDPI AG}}, series = {{International Journal of Molecular Sciences}}, title = {{Higher levels of serum zonulin may rather be associated with increased risk of obesity and hyperlipidemia, than wih gastrointestinal symptoms or disease manifestaiton}}, url = {{http://dx.doi.org/10.3390/ijms18030582}}, doi = {{10.3390/ijms18030582}}, volume = {{18}}, year = {{2017}}, }