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Insulin-like Growth Factor-I and Risk of Differentiated Thyroid Carcinoma in the European Prospective Investigation into Cancer and Nutrition

Schmidt, Julie A.; Allen, Naomi E.; Almquist, Martin LU ; Franceschi, Silvia; Rinaldi, Sabina; Tipper, Sarah J.; Tsilidis, Konstantinos K.; Weiderpass, Elisabete; Overvad, Kim and Tjonneland, Anne, et al. (2014) In Cancer Epidemiology Biomarkers & Prevention 23(6). p.976-985
Abstract
Background: Little is known about the causes of thyroid cancer, but insulin-like growth factor-I (IGF-I) might play an important role in its development due to its mitogenic and antiapoptotic properties. Methods: This study prospectively investigated the association between serum IGF-I concentrations and risk of differentiated thyroid carcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. The 345 incident cases of differentiated thyroid carcinoma were individually matched to 735 controls by study center, sex and age, date, time, and fasting status at blood collection, follow-up duration, and for women menopausal status, use of exogenous hormones, and phase of menstrual cycle at... (More)
Background: Little is known about the causes of thyroid cancer, but insulin-like growth factor-I (IGF-I) might play an important role in its development due to its mitogenic and antiapoptotic properties. Methods: This study prospectively investigated the association between serum IGF-I concentrations and risk of differentiated thyroid carcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. The 345 incident cases of differentiated thyroid carcinoma were individually matched to 735 controls by study center, sex and age, date, time, and fasting status at blood collection, follow-up duration, and for women menopausal status, use of exogenous hormones, and phase of menstrual cycle at blood collection. Serum IGF-I concentrations were measured by immunoassay, and risk of differentiated thyroid cancer in relation to IGF-I concentration was estimated using conditional logistic regression. Results: There was a positive association between IGF-I concentrations and risk of differentiated thyroid carcinoma: the OR for a doubling in IGF-I concentration was 1.48 (95% confidence interval, 1.06-2.08; P-trend = 0.02). The positive association with IGF-I was stable over time between blood collection and cancer diagnosis. Conclusion: These findings suggest that IGF-I concentrations may be positively associated with risk of differentiated thyroid carcinoma. Impact: This study provides the first prospective evidence of a potential association between circulating IGF-I concentrations and risk of differentiated thyroid carcinoma and may prompt the further investigations needed to confirm the association. (C) 2014 AACR. (Less)
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publication status
published
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Cancer Epidemiology Biomarkers & Prevention
volume
23
issue
6
pages
976 - 985
publisher
American Association for Cancer Research
external identifiers
  • wos:000345270800009
  • scopus:84903384496
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-13-1210-T
language
English
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yes
id
3e0c2630-7860-4ba8-8365-ccad69f5d1c1 (old id 4985736)
date added to LUP
2015-02-03 07:17:41
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2017-08-20 04:13:32
@article{3e0c2630-7860-4ba8-8365-ccad69f5d1c1,
  abstract     = {Background: Little is known about the causes of thyroid cancer, but insulin-like growth factor-I (IGF-I) might play an important role in its development due to its mitogenic and antiapoptotic properties. Methods: This study prospectively investigated the association between serum IGF-I concentrations and risk of differentiated thyroid carcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. The 345 incident cases of differentiated thyroid carcinoma were individually matched to 735 controls by study center, sex and age, date, time, and fasting status at blood collection, follow-up duration, and for women menopausal status, use of exogenous hormones, and phase of menstrual cycle at blood collection. Serum IGF-I concentrations were measured by immunoassay, and risk of differentiated thyroid cancer in relation to IGF-I concentration was estimated using conditional logistic regression. Results: There was a positive association between IGF-I concentrations and risk of differentiated thyroid carcinoma: the OR for a doubling in IGF-I concentration was 1.48 (95% confidence interval, 1.06-2.08; P-trend = 0.02). The positive association with IGF-I was stable over time between blood collection and cancer diagnosis. Conclusion: These findings suggest that IGF-I concentrations may be positively associated with risk of differentiated thyroid carcinoma. Impact: This study provides the first prospective evidence of a potential association between circulating IGF-I concentrations and risk of differentiated thyroid carcinoma and may prompt the further investigations needed to confirm the association. (C) 2014 AACR.},
  author       = {Schmidt, Julie A. and Allen, Naomi E. and Almquist, Martin and Franceschi, Silvia and Rinaldi, Sabina and Tipper, Sarah J. and Tsilidis, Konstantinos K. and Weiderpass, Elisabete and Overvad, Kim and Tjonneland, Anne and Boutron-Ruault, Marie-Christine and Dossus, Laure and Mesrine, Sylvie and Kaaks, Rudolf and Lukanova, Annekatrin and Boeing, Heiner and Lagiou, Pagona and Trichopoulos, Dimitrios and Trichopoulou, Antonia and Palli, Domenico and Krogh, Vittorio and Panico, Salvatore and Tumino, Rosario and Zanetti, Roberto and Bueno-de-Mesquita, H. Bas and Peeters, Petra H. and Lund, Eiliv and Menendez, Virginia and Agudo, Antonio and Sanchez, Mara-Jose and Chirlaque, Maria-Dolores and Ardanaz, Eva and Larranaga, Nerea and Hennings, Joakim and Sandstrom, Maria and Khaw, Kay-Tee and Wareham, Nick and Romieu, Isabelle and Gunter, Marc J. and Riboli, Elio and Key, Timothy J. and Travis, Ruth C.},
  issn         = {1538-7755},
  language     = {eng},
  number       = {6},
  pages        = {976--985},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Insulin-like Growth Factor-I and Risk of Differentiated Thyroid Carcinoma in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-13-1210-T},
  volume       = {23},
  year         = {2014},
}