Cytokines in childhood hemolytic uremic syndrome and thrombotic thrombocytopenic purpura
(1995) In Pediatric Nephrology 9(6). p.9-694- Abstract
Serum and urine cytokines were analyzed in children with hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Interleukin-6 (IL-6) was elevated in the serum of 33 of 35 children with HUS (94%) and in 2 of 2 children with recurrent TTP. Serum IL-6 was higher in children with HUS who developed anuria, extrarenal manifestations during the acute phase of illness and/or chronic renal sequelae. Tumor necrosis factor-alpha (TNF-alpha) was detected in the serum of 7 patients with HUS (20%) and 1 patient with TTP. IL-6 and TNF-alpha were elevated in the urine of 4 of 4 children with HUS and 2 of 2 children with TTP. Urinary levels were higher than serum levels, suggesting local production of cytokines in the urinary... (More)
Serum and urine cytokines were analyzed in children with hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Interleukin-6 (IL-6) was elevated in the serum of 33 of 35 children with HUS (94%) and in 2 of 2 children with recurrent TTP. Serum IL-6 was higher in children with HUS who developed anuria, extrarenal manifestations during the acute phase of illness and/or chronic renal sequelae. Tumor necrosis factor-alpha (TNF-alpha) was detected in the serum of 7 patients with HUS (20%) and 1 patient with TTP. IL-6 and TNF-alpha were elevated in the urine of 4 of 4 children with HUS and 2 of 2 children with TTP. Urinary levels were higher than serum levels, suggesting local production of cytokines in the urinary tract. Sequential serum and urine samples showed that IL-6 levels varied with disease activity. IL-6 and TNF-alpha were not detected in the serum (n = 25) and urine (n = 15) of healthy children. We conclude that IL-6 in urine may be used to monitor disease activity in HUS and TTP.
(Less)
- author
- Karpman, D LU ; Andreasson, Annika ; Thysell, H LU ; Kaplan, B S and Svanborg, C LU
- organization
- publishing date
- 1995-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adolescent, Child, Child, Preschool, Cytokines, Female, Hemolytic-Uremic Syndrome, Humans, Infant, Interleukin-6, Male, Purpura, Thrombotic Thrombocytopenic, Renal Dialysis, Serum Globulins, Tumor Necrosis Factor-alpha, Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't
- in
- Pediatric Nephrology
- volume
- 9
- issue
- 6
- pages
- 6 pages
- publisher
- Springer
- external identifiers
-
- pmid:8747107
- scopus:0029614735
- ISSN
- 0931-041X
- DOI
- 10.1007/BF00868714
- language
- English
- LU publication?
- yes
- id
- 4992100e-20e4-404a-a449-7c47ecb5aea7
- date added to LUP
- 2017-02-08 16:07:51
- date last changed
- 2024-01-13 13:38:36
@article{4992100e-20e4-404a-a449-7c47ecb5aea7, abstract = {{<p>Serum and urine cytokines were analyzed in children with hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Interleukin-6 (IL-6) was elevated in the serum of 33 of 35 children with HUS (94%) and in 2 of 2 children with recurrent TTP. Serum IL-6 was higher in children with HUS who developed anuria, extrarenal manifestations during the acute phase of illness and/or chronic renal sequelae. Tumor necrosis factor-alpha (TNF-alpha) was detected in the serum of 7 patients with HUS (20%) and 1 patient with TTP. IL-6 and TNF-alpha were elevated in the urine of 4 of 4 children with HUS and 2 of 2 children with TTP. Urinary levels were higher than serum levels, suggesting local production of cytokines in the urinary tract. Sequential serum and urine samples showed that IL-6 levels varied with disease activity. IL-6 and TNF-alpha were not detected in the serum (n = 25) and urine (n = 15) of healthy children. We conclude that IL-6 in urine may be used to monitor disease activity in HUS and TTP.</p>}}, author = {{Karpman, D and Andreasson, Annika and Thysell, H and Kaplan, B S and Svanborg, C}}, issn = {{0931-041X}}, keywords = {{Adolescent; Child; Child, Preschool; Cytokines; Female; Hemolytic-Uremic Syndrome; Humans; Infant; Interleukin-6; Male; Purpura, Thrombotic Thrombocytopenic; Renal Dialysis; Serum Globulins; Tumor Necrosis Factor-alpha; Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't}}, language = {{eng}}, number = {{6}}, pages = {{9--694}}, publisher = {{Springer}}, series = {{Pediatric Nephrology}}, title = {{Cytokines in childhood hemolytic uremic syndrome and thrombotic thrombocytopenic purpura}}, url = {{http://dx.doi.org/10.1007/BF00868714}}, doi = {{10.1007/BF00868714}}, volume = {{9}}, year = {{1995}}, }