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Cytokines in childhood hemolytic uremic syndrome and thrombotic thrombocytopenic purpura

Karpman, D LU ; Andreasson, Annika; Thysell, H LU ; Kaplan, B S and Svanborg, C LU (1995) In Pediatric Nephrology 9(6). p.9-694
Abstract

Serum and urine cytokines were analyzed in children with hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Interleukin-6 (IL-6) was elevated in the serum of 33 of 35 children with HUS (94%) and in 2 of 2 children with recurrent TTP. Serum IL-6 was higher in children with HUS who developed anuria, extrarenal manifestations during the acute phase of illness and/or chronic renal sequelae. Tumor necrosis factor-alpha (TNF-alpha) was detected in the serum of 7 patients with HUS (20%) and 1 patient with TTP. IL-6 and TNF-alpha were elevated in the urine of 4 of 4 children with HUS and 2 of 2 children with TTP. Urinary levels were higher than serum levels, suggesting local production of cytokines in the urinary... (More)

Serum and urine cytokines were analyzed in children with hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Interleukin-6 (IL-6) was elevated in the serum of 33 of 35 children with HUS (94%) and in 2 of 2 children with recurrent TTP. Serum IL-6 was higher in children with HUS who developed anuria, extrarenal manifestations during the acute phase of illness and/or chronic renal sequelae. Tumor necrosis factor-alpha (TNF-alpha) was detected in the serum of 7 patients with HUS (20%) and 1 patient with TTP. IL-6 and TNF-alpha were elevated in the urine of 4 of 4 children with HUS and 2 of 2 children with TTP. Urinary levels were higher than serum levels, suggesting local production of cytokines in the urinary tract. Sequential serum and urine samples showed that IL-6 levels varied with disease activity. IL-6 and TNF-alpha were not detected in the serum (n = 25) and urine (n = 15) of healthy children. We conclude that IL-6 in urine may be used to monitor disease activity in HUS and TTP.

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published
subject
keywords
Adolescent, Child, Child, Preschool, Cytokines, Female, Hemolytic-Uremic Syndrome, Humans, Infant, Interleukin-6, Male, Purpura, Thrombotic Thrombocytopenic, Renal Dialysis, Serum Globulins, Tumor Necrosis Factor-alpha, Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't
in
Pediatric Nephrology
volume
9
issue
6
pages
6 pages
publisher
Springer
external identifiers
  • scopus:0029614735
ISSN
0931-041X
DOI
10.1007/BF00868714
language
English
LU publication?
yes
id
4992100e-20e4-404a-a449-7c47ecb5aea7
date added to LUP
2017-02-08 16:07:51
date last changed
2017-10-22 05:26:15
@article{4992100e-20e4-404a-a449-7c47ecb5aea7,
  abstract     = {<p>Serum and urine cytokines were analyzed in children with hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Interleukin-6 (IL-6) was elevated in the serum of 33 of 35 children with HUS (94%) and in 2 of 2 children with recurrent TTP. Serum IL-6 was higher in children with HUS who developed anuria, extrarenal manifestations during the acute phase of illness and/or chronic renal sequelae. Tumor necrosis factor-alpha (TNF-alpha) was detected in the serum of 7 patients with HUS (20%) and 1 patient with TTP. IL-6 and TNF-alpha were elevated in the urine of 4 of 4 children with HUS and 2 of 2 children with TTP. Urinary levels were higher than serum levels, suggesting local production of cytokines in the urinary tract. Sequential serum and urine samples showed that IL-6 levels varied with disease activity. IL-6 and TNF-alpha were not detected in the serum (n = 25) and urine (n = 15) of healthy children. We conclude that IL-6 in urine may be used to monitor disease activity in HUS and TTP.</p>},
  author       = {Karpman, D and Andreasson, Annika and Thysell, H and Kaplan, B S and Svanborg, C},
  issn         = {0931-041X},
  keyword      = {Adolescent,Child,Child, Preschool,Cytokines,Female,Hemolytic-Uremic Syndrome,Humans,Infant,Interleukin-6,Male,Purpura, Thrombotic Thrombocytopenic,Renal Dialysis,Serum Globulins,Tumor Necrosis Factor-alpha,Clinical Trial,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {6},
  pages        = {9--694},
  publisher    = {Springer},
  series       = {Pediatric Nephrology},
  title        = {Cytokines in childhood hemolytic uremic syndrome and thrombotic thrombocytopenic purpura},
  url          = {http://dx.doi.org/10.1007/BF00868714},
  volume       = {9},
  year         = {1995},
}