Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals
(2018) In Journal of Investigative Medicine 66(6). p.1019-1022- Abstract
Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is a mitochondrial-derived peptide that attenuates weight gain and hyperinsulinemia when administered to high fat-fed mice. MOTS-c is therefore a potential regulator of metabolic homeostasis under conditions of high-energy supply. However, the effect of insulin resistance and obesity on plasma MOTS-c concentration in humans is unknown. To gain insight into MOTS-c regulation, we measured plasma MOTS-c concentration and analyzed its relationship with insulin sensitivity surrogates, in lean and obese humans (n=10 per group). Obese individuals had impaired insulin sensitivity as indicated by low Matsuda and high Homeostatic Model Assessment (HOMA) indexes. Although plasma MOTS-c... (More)
Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is a mitochondrial-derived peptide that attenuates weight gain and hyperinsulinemia when administered to high fat-fed mice. MOTS-c is therefore a potential regulator of metabolic homeostasis under conditions of high-energy supply. However, the effect of insulin resistance and obesity on plasma MOTS-c concentration in humans is unknown. To gain insight into MOTS-c regulation, we measured plasma MOTS-c concentration and analyzed its relationship with insulin sensitivity surrogates, in lean and obese humans (n=10 per group). Obese individuals had impaired insulin sensitivity as indicated by low Matsuda and high Homeostatic Model Assessment (HOMA) indexes. Although plasma MOTS-c concentration was similar in lean and obese individuals (0.48±0.16 and 0.52±0.15 ng/mL; p=0.60), it was correlated with HOMA (r=0.53; p<0.05) and Matsuda index (r=-0.46; p<0.05). Notably, when the groups were analyzed separately, the associations remained only in lean individuals. We conclude that plasma MOTS-c concentration is unaltered in human obesity. However, MOTS-c associates positively with insulin resistance mostly in lean individuals, indicating that plasma MOTS-c concentration depends on the metabolic status in this population. Such dependence seems altered when obesity settles. The implications of plasma MOTS-c for human metabolic homeostasis deserve future examination.
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- author
- Cataldo, Luis Rodrigo LU ; Fernández-Verdejo, Rodrigo ; Santos, José Luis and Galgani, Jose Eduardo
- publishing date
- 2018-03-27
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Journal Article
- in
- Journal of Investigative Medicine
- volume
- 66
- issue
- 6
- pages
- 1019 - 1022
- publisher
- BMJ Publishing Group
- external identifiers
-
- scopus:85049123520
- pmid:29593067
- ISSN
- 1708-8267
- DOI
- 10.1136/jim-2017-000681
- language
- English
- LU publication?
- no
- id
- 4a05c7d2-aafb-4fc0-b1ec-a839fc2bbc40
- date added to LUP
- 2018-04-06 13:37:30
- date last changed
- 2024-10-15 00:26:06
@article{4a05c7d2-aafb-4fc0-b1ec-a839fc2bbc40, abstract = {{<p>Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is a mitochondrial-derived peptide that attenuates weight gain and hyperinsulinemia when administered to high fat-fed mice. MOTS-c is therefore a potential regulator of metabolic homeostasis under conditions of high-energy supply. However, the effect of insulin resistance and obesity on plasma MOTS-c concentration in humans is unknown. To gain insight into MOTS-c regulation, we measured plasma MOTS-c concentration and analyzed its relationship with insulin sensitivity surrogates, in lean and obese humans (n=10 per group). Obese individuals had impaired insulin sensitivity as indicated by low Matsuda and high Homeostatic Model Assessment (HOMA) indexes. Although plasma MOTS-c concentration was similar in lean and obese individuals (0.48±0.16 and 0.52±0.15 ng/mL; p=0.60), it was correlated with HOMA (r=0.53; p<0.05) and Matsuda index (r=-0.46; p<0.05). Notably, when the groups were analyzed separately, the associations remained only in lean individuals. We conclude that plasma MOTS-c concentration is unaltered in human obesity. However, MOTS-c associates positively with insulin resistance mostly in lean individuals, indicating that plasma MOTS-c concentration depends on the metabolic status in this population. Such dependence seems altered when obesity settles. The implications of plasma MOTS-c for human metabolic homeostasis deserve future examination.</p>}}, author = {{Cataldo, Luis Rodrigo and Fernández-Verdejo, Rodrigo and Santos, José Luis and Galgani, Jose Eduardo}}, issn = {{1708-8267}}, keywords = {{Journal Article}}, language = {{eng}}, month = {{03}}, number = {{6}}, pages = {{1019--1022}}, publisher = {{BMJ Publishing Group}}, series = {{Journal of Investigative Medicine}}, title = {{Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals}}, url = {{http://dx.doi.org/10.1136/jim-2017-000681}}, doi = {{10.1136/jim-2017-000681}}, volume = {{66}}, year = {{2018}}, }