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Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals

Cataldo, Luis Rodrigo LU ; Fernández-Verdejo, Rodrigo ; Santos, José Luis and Galgani, Jose Eduardo (2018) In Journal of Investigative Medicine
Abstract

Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is a mitochondrial-derived peptide that attenuates weight gain and hyperinsulinemia when administered to high fat-fed mice. MOTS-c is therefore a potential regulator of metabolic homeostasis under conditions of high-energy supply. However, the effect of insulin resistance and obesity on plasma MOTS-c concentration in humans is unknown. To gain insight into MOTS-c regulation, we measured plasma MOTS-c concentration and analyzed its relationship with insulin sensitivity surrogates, in lean and obese humans (n=10 per group). Obese individuals had impaired insulin sensitivity as indicated by low Matsuda and high Homeostatic Model Assessment (HOMA) indexes. Although plasma MOTS-c... (More)

Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is a mitochondrial-derived peptide that attenuates weight gain and hyperinsulinemia when administered to high fat-fed mice. MOTS-c is therefore a potential regulator of metabolic homeostasis under conditions of high-energy supply. However, the effect of insulin resistance and obesity on plasma MOTS-c concentration in humans is unknown. To gain insight into MOTS-c regulation, we measured plasma MOTS-c concentration and analyzed its relationship with insulin sensitivity surrogates, in lean and obese humans (n=10 per group). Obese individuals had impaired insulin sensitivity as indicated by low Matsuda and high Homeostatic Model Assessment (HOMA) indexes. Although plasma MOTS-c concentration was similar in lean and obese individuals (0.48±0.16 and 0.52±0.15 ng/mL; p=0.60), it was correlated with HOMA (r=0.53; p<0.05) and Matsuda index (r=-0.46; p<0.05). Notably, when the groups were analyzed separately, the associations remained only in lean individuals. We conclude that plasma MOTS-c concentration is unaltered in human obesity. However, MOTS-c associates positively with insulin resistance mostly in lean individuals, indicating that plasma MOTS-c concentration depends on the metabolic status in this population. Such dependence seems altered when obesity settles. The implications of plasma MOTS-c for human metabolic homeostasis deserve future examination.

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author
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publication status
epub
subject
keywords
Journal Article
in
Journal of Investigative Medicine
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85049123520
  • pmid:29593067
ISSN
1708-8267
DOI
10.1136/jim-2017-000681
language
English
LU publication?
no
id
4a05c7d2-aafb-4fc0-b1ec-a839fc2bbc40
date added to LUP
2018-04-06 13:37:30
date last changed
2020-02-26 06:46:19
@article{4a05c7d2-aafb-4fc0-b1ec-a839fc2bbc40,
  abstract     = {<p>Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is a mitochondrial-derived peptide that attenuates weight gain and hyperinsulinemia when administered to high fat-fed mice. MOTS-c is therefore a potential regulator of metabolic homeostasis under conditions of high-energy supply. However, the effect of insulin resistance and obesity on plasma MOTS-c concentration in humans is unknown. To gain insight into MOTS-c regulation, we measured plasma MOTS-c concentration and analyzed its relationship with insulin sensitivity surrogates, in lean and obese humans (n=10 per group). Obese individuals had impaired insulin sensitivity as indicated by low Matsuda and high Homeostatic Model Assessment (HOMA) indexes. Although plasma MOTS-c concentration was similar in lean and obese individuals (0.48±0.16 and 0.52±0.15 ng/mL; p=0.60), it was correlated with HOMA (r=0.53; p&lt;0.05) and Matsuda index (r=-0.46; p&lt;0.05). Notably, when the groups were analyzed separately, the associations remained only in lean individuals. We conclude that plasma MOTS-c concentration is unaltered in human obesity. However, MOTS-c associates positively with insulin resistance mostly in lean individuals, indicating that plasma MOTS-c concentration depends on the metabolic status in this population. Such dependence seems altered when obesity settles. The implications of plasma MOTS-c for human metabolic homeostasis deserve future examination.</p>},
  author       = {Cataldo, Luis Rodrigo and Fernández-Verdejo, Rodrigo and Santos, José Luis and Galgani, Jose Eduardo},
  issn         = {1708-8267},
  language     = {eng},
  month        = {03},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Investigative Medicine},
  title        = {Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals},
  url          = {http://dx.doi.org/10.1136/jim-2017-000681},
  doi          = {10.1136/jim-2017-000681},
  year         = {2018},
}