Copeptin relates to a fatty liver and measures of obesity in a South African population with mixed ethnicities
(2019) In Endocrine 65(2). p.304-311- Abstract
Purpose: Elevated copeptin, a vasopressin marker, is linked to metabolic disease, and obese rats with low-vasopressin concentration had a decreased risk of liver steatosis. We here investigated the association between copeptin and nonalcoholic fatty liver disease (NAFLD) and possible differences in copeptin concentration between ethnicities. Methods: In this cross-sectional study of 361 South Africans (n = 172 African black, 189 = Caucasian) with a mean age of 45 years and 45% men, plasma copeptin was measured and associated with NAFLD according to a validated fatty liver index accounting for measures of BMI, waist, triglycerides, and gamma-glutamyltransferase. Results: There was no significant difference in copeptin concentrations... (More)
Purpose: Elevated copeptin, a vasopressin marker, is linked to metabolic disease, and obese rats with low-vasopressin concentration had a decreased risk of liver steatosis. We here investigated the association between copeptin and nonalcoholic fatty liver disease (NAFLD) and possible differences in copeptin concentration between ethnicities. Methods: In this cross-sectional study of 361 South Africans (n = 172 African black, 189 = Caucasian) with a mean age of 45 years and 45% men, plasma copeptin was measured and associated with NAFLD according to a validated fatty liver index accounting for measures of BMI, waist, triglycerides, and gamma-glutamyltransferase. Results: There was no significant difference in copeptin concentrations between ethnicities after age and gender adjustment (p = 0.24). Increasing copeptin tertile levels were significantly associated with obesity, overweight, and abdominal obesity, respectively, after multivariate adjustment for age, gender, ethnicity, and high HOMA-IR (p = 0.02 for all). Individuals in the second and third copeptin tertile had an increased odds (95% CI) of NAFLD of 1.77 (1.04–3.02) and 2.97 (1.74–5.06), respectively, compared to the bottom tertile (p < 0.001). The association between increasing copeptin tertile and NAFLD remained significant after adjustment for age, gender, ethnicity, high HOMA-IR, self-reported current alcohol intake, and statin treatment (p = 0.01). Conclusions: Elevated plasma copeptin is independently associated with NAFLD in a population with mixed ethnicities, pointing at the pharmacologically modifiable vasopressin system as a new mechanism behind NAFLD.
(Less)
- author
- Enhörning, Sofia LU and Malan, Léone
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Gamma glutamyl transferase, NAFLD, Triglycerides, Vasopressin
- in
- Endocrine
- volume
- 65
- issue
- 2
- pages
- 304 - 311
- publisher
- Humana Press
- external identifiers
-
- pmid:31230225
- scopus:85067869682
- ISSN
- 1355-008X
- DOI
- 10.1007/s12020-019-01977-y
- language
- English
- LU publication?
- yes
- id
- 4a4e4e23-ef4e-4067-99b9-283f6afcae18
- date added to LUP
- 2019-07-08 11:02:27
- date last changed
- 2024-03-19 17:05:59
@article{4a4e4e23-ef4e-4067-99b9-283f6afcae18,
abstract = {{<p>Purpose: Elevated copeptin, a vasopressin marker, is linked to metabolic disease, and obese rats with low-vasopressin concentration had a decreased risk of liver steatosis. We here investigated the association between copeptin and nonalcoholic fatty liver disease (NAFLD) and possible differences in copeptin concentration between ethnicities. Methods: In this cross-sectional study of 361 South Africans (n = 172 African black, 189 = Caucasian) with a mean age of 45 years and 45% men, plasma copeptin was measured and associated with NAFLD according to a validated fatty liver index accounting for measures of BMI, waist, triglycerides, and gamma-glutamyltransferase. Results: There was no significant difference in copeptin concentrations between ethnicities after age and gender adjustment (p = 0.24). Increasing copeptin tertile levels were significantly associated with obesity, overweight, and abdominal obesity, respectively, after multivariate adjustment for age, gender, ethnicity, and high HOMA-IR (p = 0.02 for all). Individuals in the second and third copeptin tertile had an increased odds (95% CI) of NAFLD of 1.77 (1.04–3.02) and 2.97 (1.74–5.06), respectively, compared to the bottom tertile (p < 0.001). The association between increasing copeptin tertile and NAFLD remained significant after adjustment for age, gender, ethnicity, high HOMA-IR, self-reported current alcohol intake, and statin treatment (p = 0.01). Conclusions: Elevated plasma copeptin is independently associated with NAFLD in a population with mixed ethnicities, pointing at the pharmacologically modifiable vasopressin system as a new mechanism behind NAFLD.</p>}},
author = {{Enhörning, Sofia and Malan, Léone}},
issn = {{1355-008X}},
keywords = {{Gamma glutamyl transferase; NAFLD; Triglycerides; Vasopressin}},
language = {{eng}},
number = {{2}},
pages = {{304--311}},
publisher = {{Humana Press}},
series = {{Endocrine}},
title = {{Copeptin relates to a fatty liver and measures of obesity in a South African population with mixed ethnicities}},
url = {{http://dx.doi.org/10.1007/s12020-019-01977-y}},
doi = {{10.1007/s12020-019-01977-y}},
volume = {{65}},
year = {{2019}},
}