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Near-haploid and low hypodiploid acute lymphoblastic leukemia - two distinct subtypes but consistently poor prognosis

Safavi, Setareh LU and Paulsson, Kajsa LU (2017) In Blood 129(4). p.420-423
Abstract

Hypodiploidy <40 chromosomes is an uncommon genetic feature of acute lymphoblastic leukemia (ALL) in both children and adults. It has long been clear by cytogenetic analyses, and recently confirmed by mutational profiling, that these cases may be further subdivided into two subtypes: near-haploid ALL with 24-30 chromosomes and low hypodiploid ALL with 31-39 chromosomes. Both groups are associated with a very poor prognosis and these patients are among those who could benefit most from novel treatments.

Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
129
issue
4
pages
420 - 423
publisher
American Society of Hematology
external identifiers
  • scopus:85014910236
  • wos:000396531400008
  • pmid:27903530
ISSN
1528-0020
DOI
10.1182/blood-2016-10-743765
language
English
LU publication?
yes
id
4a54b372-6b38-49b1-b359-3ce97c763727
date added to LUP
2017-01-25 13:25:01
date last changed
2025-04-04 14:50:16
@article{4a54b372-6b38-49b1-b359-3ce97c763727,
  abstract     = {{<p>Hypodiploidy &lt;40 chromosomes is an uncommon genetic feature of acute lymphoblastic leukemia (ALL) in both children and adults. It has long been clear by cytogenetic analyses, and recently confirmed by mutational profiling, that these cases may be further subdivided into two subtypes: near-haploid ALL with 24-30 chromosomes and low hypodiploid ALL with 31-39 chromosomes. Both groups are associated with a very poor prognosis and these patients are among those who could benefit most from novel treatments.</p>}},
  author       = {{Safavi, Setareh and Paulsson, Kajsa}},
  issn         = {{1528-0020}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{420--423}},
  publisher    = {{American Society of Hematology}},
  series       = {{Blood}},
  title        = {{Near-haploid and low hypodiploid acute lymphoblastic leukemia - two distinct subtypes but consistently poor prognosis}},
  url          = {{https://lup.lub.lu.se/search/files/27447510/20274458.pdf}},
  doi          = {{10.1182/blood-2016-10-743765}},
  volume       = {{129}},
  year         = {{2017}},
}