From cohorts to molecules : Adverse impacts of endocrine disrupting mixtures
(2022) In Science 375(6582).- Abstract
Convergent evidence associates exposure to endocrine disrupting chemicals (EDCs) with major human diseases, even at regulation-compliant concentrations. This might be because humans are exposed to EDC mixtures, whereas chemical regulation is based on a risk assessment of individual compounds. Here, we developed a mixture-centered risk assessment strategy that integrates epidemiological and experimental evidence. We identified that exposure to an EDC mixture in early pregnancy is associated with language delay in offspring. At human-relevant concentrations, this mixture disrupted hormone-regulated and disease-relevant regulatory networks in human brain organoids and in the model organisms Xenopus leavis and Danio rerio, as well as... (More)
Convergent evidence associates exposure to endocrine disrupting chemicals (EDCs) with major human diseases, even at regulation-compliant concentrations. This might be because humans are exposed to EDC mixtures, whereas chemical regulation is based on a risk assessment of individual compounds. Here, we developed a mixture-centered risk assessment strategy that integrates epidemiological and experimental evidence. We identified that exposure to an EDC mixture in early pregnancy is associated with language delay in offspring. At human-relevant concentrations, this mixture disrupted hormone-regulated and disease-relevant regulatory networks in human brain organoids and in the model organisms Xenopus leavis and Danio rerio, as well as behavioral responses. Reinterrogating epidemiological data, we found that up to 54% of the children had prenatal exposures above experimentally derived levels of concern, reaching, for the upper decile compared with the lowest decile of exposure, a 3.3 times higher risk of language delay.
(Less)
- author
- organization
- publishing date
- 2022-02
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Science
- volume
- 375
- issue
- 6582
- article number
- eabe8244
- publisher
- American Association for the Advancement of Science (AAAS)
- external identifiers
-
- pmid:35175820
- scopus:85124775819
- ISSN
- 0036-8075
- DOI
- 10.1126/science.abe8244
- language
- English
- LU publication?
- yes
- id
- 4a613e1d-8624-4ad5-b071-23d14fb5c7da
- date added to LUP
- 2022-04-12 15:12:02
- date last changed
- 2025-02-12 02:27:21
@article{4a613e1d-8624-4ad5-b071-23d14fb5c7da, abstract = {{<p>Convergent evidence associates exposure to endocrine disrupting chemicals (EDCs) with major human diseases, even at regulation-compliant concentrations. This might be because humans are exposed to EDC mixtures, whereas chemical regulation is based on a risk assessment of individual compounds. Here, we developed a mixture-centered risk assessment strategy that integrates epidemiological and experimental evidence. We identified that exposure to an EDC mixture in early pregnancy is associated with language delay in offspring. At human-relevant concentrations, this mixture disrupted hormone-regulated and disease-relevant regulatory networks in human brain organoids and in the model organisms Xenopus leavis and Danio rerio, as well as behavioral responses. Reinterrogating epidemiological data, we found that up to 54% of the children had prenatal exposures above experimentally derived levels of concern, reaching, for the upper decile compared with the lowest decile of exposure, a 3.3 times higher risk of language delay.</p>}}, author = {{Caporale, Nicolò and Leemans, Michelle and Birgersson, Lina and Germain, Pierre Luc and Cheroni, Cristina and Borbély, Gábor and Engdahl, Elin and Lindh, Christian and Bressan, Raul Bardini and Cavallo, Francesca and Chorev, Nadav Even and D’Agostino, Giuseppe Alessandro and Pollard, Steven M. and Rigoli, Marco Tullio and Tenderini, Erika and Tobon, Alejandro Lopeg and Trattaro, Sebastiano and Troglio, Flavia and Zanella, Matteo and Bergman, Åke and Damdimopoulou, Pauliina and Jönsson, Maria and Kiess, Wieland and Kitraki, Efthymia and Kiviranta, Hannu and Nånberg, Eewa and Öberg, Mattias and Rantakokko, Panu and Rudén, Christina and Söder, Olle and Bornehag, Carl Gustaf and Demeneix, Barbara and Fini, Jean Baptiste and Gennings, Chris and Rüegg, Joëlle and Sturve, Joachim and Testa, Giuseppe}}, issn = {{0036-8075}}, language = {{eng}}, number = {{6582}}, publisher = {{American Association for the Advancement of Science (AAAS)}}, series = {{Science}}, title = {{From cohorts to molecules : Adverse impacts of endocrine disrupting mixtures}}, url = {{http://dx.doi.org/10.1126/science.abe8244}}, doi = {{10.1126/science.abe8244}}, volume = {{375}}, year = {{2022}}, }