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Panel of significant risk factors predicts early stage gastric cancer and indication of poor prognostic association with pathogens and microsatellite stability

Chakraborty, Payel LU ; Ghatak, Souvik LU ; Chenkual, Saia ; Pachuau, Lalawmpuii ; Zohmingthanga, John ; Bawihtlung, Zothankima ; Khenglawt, Lalfakzuala ; Pautu, Jeremy L ; Maitra, Arindam and Chhakchhuak, Lalchhandama , et al. (2021) In Genes and Environment 43(1).
Abstract

BACKGROUND: There are very few studies covering the epidemiological risk factors associated with Epstein Barr Virus (EBV) and Microsatellite stability for Gastric Cancer (GC) cases. Early diagnosis of GC through epidemiological risk factors is very necessary for the clinical assessment of GC. The aim of this study was to find out the major risk factors to predict GC in early stage and the impact of pathogen infection and MSI on survival rate of patients. GC samples were screened for Helicobacter pylori, Epstein Barr Virus, and Mismatch repair (MMR) gene status (microsatellite stable or instable). Chi-square and logistic regression analysis of Odd ratio and 95% confidence interval (OR, 95% CI) were performed to find out the association... (More)

BACKGROUND: There are very few studies covering the epidemiological risk factors associated with Epstein Barr Virus (EBV) and Microsatellite stability for Gastric Cancer (GC) cases. Early diagnosis of GC through epidemiological risk factors is very necessary for the clinical assessment of GC. The aim of this study was to find out the major risk factors to predict GC in early stage and the impact of pathogen infection and MSI on survival rate of patients. GC samples were screened for Helicobacter pylori, Epstein Barr Virus, and Mismatch repair (MMR) gene status (microsatellite stable or instable). Chi-square and logistic regression analysis of Odd ratio and 95% confidence interval (OR, 95% CI) were performed to find out the association between epidemiological factors and the risk of gastric cancer. The pathogen and MMR gene status were analysed to predict their effect on overall survival and the risk score and hazard ratio was calculated for prognostic assessment.

RESULTS: Excess body weight, consumption of extra salt, smoked food, alcohol, and smoking were the major risk factors for GC development. This study achieved a high area under the curve (AUC 0.94) for the probable GC patients in early-stage using the five-panel epidemiological risk factors. H. pylori infected cases were significant with smoked food, while EBV was found to be associated with tuibur intake and smoked food. In overall survival analysis EBV infected and microsatellite stable (HR: 1.32 and 1.34 respectively) GC cases were showing poor prognosis.

CONCLUSION: This study might provide new opportunities for personalized treatment options using this epidemiological factor risk score and clinicopathological factors assessment for early detection and prognosis in high-risk GC populations.

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publishing date
type
Contribution to journal
publication status
published
subject
in
Genes and Environment
volume
43
issue
1
article number
3
publisher
BioMed Central (BMC)
external identifiers
  • pmid:33568233
  • scopus:85100743673
ISSN
1880-7046
DOI
10.1186/s41021-021-00174-6
language
English
LU publication?
no
id
4a96e585-fc3a-4189-800d-39c1d2a06c49
date added to LUP
2021-10-28 15:38:48
date last changed
2024-05-18 17:47:56
@article{4a96e585-fc3a-4189-800d-39c1d2a06c49,
  abstract     = {{<p>BACKGROUND: There are very few studies covering the epidemiological risk factors associated with Epstein Barr Virus (EBV) and Microsatellite stability for Gastric Cancer (GC) cases. Early diagnosis of GC through epidemiological risk factors is very necessary for the clinical assessment of GC. The aim of this study was to find out the major risk factors to predict GC in early stage and the impact of pathogen infection and MSI on survival rate of patients. GC samples were screened for Helicobacter pylori, Epstein Barr Virus, and Mismatch repair (MMR) gene status (microsatellite stable or instable). Chi-square and logistic regression analysis of Odd ratio and 95% confidence interval (OR, 95% CI) were performed to find out the association between epidemiological factors and the risk of gastric cancer. The pathogen and MMR gene status were analysed to predict their effect on overall survival and the risk score and hazard ratio was calculated for prognostic assessment.</p><p>RESULTS: Excess body weight, consumption of extra salt, smoked food, alcohol, and smoking were the major risk factors for GC development. This study achieved a high area under the curve (AUC 0.94) for the probable GC patients in early-stage using the five-panel epidemiological risk factors. H. pylori infected cases were significant with smoked food, while EBV was found to be associated with tuibur intake and smoked food. In overall survival analysis EBV infected and microsatellite stable (HR: 1.32 and 1.34 respectively) GC cases were showing poor prognosis.</p><p>CONCLUSION: This study might provide new opportunities for personalized treatment options using this epidemiological factor risk score and clinicopathological factors assessment for early detection and prognosis in high-risk GC populations.</p>}},
  author       = {{Chakraborty, Payel and Ghatak, Souvik and Chenkual, Saia and Pachuau, Lalawmpuii and Zohmingthanga, John and Bawihtlung, Zothankima and Khenglawt, Lalfakzuala and Pautu, Jeremy L and Maitra, Arindam and Chhakchhuak, Lalchhandama and Kumar, Nachimuthu Senthil}},
  issn         = {{1880-7046}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Genes and Environment}},
  title        = {{Panel of significant risk factors predicts early stage gastric cancer and indication of poor prognostic association with pathogens and microsatellite stability}},
  url          = {{http://dx.doi.org/10.1186/s41021-021-00174-6}},
  doi          = {{10.1186/s41021-021-00174-6}},
  volume       = {{43}},
  year         = {{2021}},
}